High Cut-Off Membrane Hemodiafiltration in Myoglobinuric Acute Renal Failure: A Case Series

2011 ◽  
Vol 15 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Vladimir Premru ◽  
Janko Kovač ◽  
Jadranka Buturović-Ponikvar ◽  
Rafael Ponikvar
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Case Series ◽  
Myoglobinuric Acute Renal Failure

scholarly journals Low-Dose Aminophylline for the Treatment of Neonatal Non-Oliguric Renal Failure—Case Series and Review of the Literature

2008 ◽  
Vol 13 (2) ◽  
pp. 80-87
Author(s):  
Bethany A. Lynch ◽  
Peter Gal ◽  
J. Laurence Ransom ◽  
Rita Q. Carlos ◽  
Mary Ann V.T. Dimaguila ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Chart Review ◽  
Low Dose ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Review Of The Literature ◽  
Oliguric Renal Failure ◽  
The Impact

OBJECTIVE Aminophylline is a methylxanthine with multiple physiologic actions. At low doses, aminophylline can antagonize adenosine and improve renal function via increased glomerular filtration rate. Despite its clinical use, little data exists in neonates for this indication. Therefore, the objective of this report is to describe the impact of aminophylline on renal function indices in a series of neonates with acute renal failure. MATERIALS AND METHODS This was a retrospective chart review of 13 neonates with acute renal failure who received aminophylline during a 15-month study period. Aminophylline was administered at 1 mg/kg intravenously or orally every twelve hours. Forty-six percent (n = 6) of the patients received a 5 mg/kg loading dose before initiation of maintenance therapy. Most patients had already received other treatments for renal failure, including diuretics and dopamine. RESULTS Resolution of acute renal failure (with normalization of serum creatinine and blood urea nitrogen) was documented in 10 patients (77%). Four of the thirteen patients died from complications due to their prematurity. Failure of low-dose aminophylline was observed in 3 of the 4 patients who died. CONCLUSIONS Low-dose aminophylline in neonates with acute renal failure is associated with an improvement in renal function indices.

scholarly journals Effects of Exogenous Melatonin on Myoglobinuric Acute Renal Failure in the Rats

Renal Failure ◽  
2004 ◽  
Vol 26 (5) ◽  
pp. 479-486 ◽  
Author(s):  
Nurettin Aydogdu ◽  
Gulizar Atmaca ◽  
Omer Yalcin ◽  
Kadir Batcioglu ◽  
Kadir Kaymak
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Exogenous Melatonin ◽  
Myoglobinuric Acute Renal Failure

Myoglobinuric acute renal failure in phencyclidine overdose: Report of observations in eight cases

1980 ◽  
Vol 9 (11) ◽  
pp. 549-553 ◽  
Author(s):  
Raman Patel ◽  
Malay Das ◽  
Michael Palazzolo ◽  
Ali Ansarl ◽  
Subramaniam Balasubramaniam
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Myoglobinuric Acute Renal Failure

Reversal of Experimental Myoglobinuric Acute Renal Failure in Rats by Quercetin, a Bioflavonoid

Pharmacology ◽  
2004 ◽  
Vol 73 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Vikas Chander ◽  
Devinder Singh ◽  
Kanwaljit Chopra
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Myoglobinuric Acute Renal Failure

Theophylline-induced protection in myoglobinuric acute renal failure: further characterization

1987 ◽  
Vol 65 (1) ◽  
pp. 42-45 ◽  
Author(s):  
A. K. Bidani ◽  
P. C. Churchill ◽  
W. Packer
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Serum Creatinine ◽  
Biological Fluids ◽  
Peak Serum ◽  
Tubuloglomerular Feedback ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Adenosine Receptor Antagonist ◽  
Myoglobinuric Acute Renal Failure

We have reported previously that aminophylline has an ameliorating effect on the course and severity of glycerol-induced myoglobinuric acute renal failure in rats. Since aminophylline dissociates into theophylline in biological fluids and since theophylline is an adenosine receptor antagonist, we attributed the ameliorating effects to antagonism of the hemodynamic effects of endogenous adenosine. However, theophylline blocks tubuloglomerular feedback and produces natriuresis, and either of these effects might have accounted for the beneficial effects in acute renal failure. Therefore, this study was designed to further characterize the effects of theophylline in glycerol-induced acute renal failure in rats. Aminophylline had dose-dependent beneficial effects, as judged by the peak serum creatinine during the 3 days following induction of acute renal failure, by the number of animals with peak serum creatinine >1 mg/dL, and by the mortality rate. Both furosemide and theophylline block tubuloglomerular feedback and produce natriuresis, but aminophylline had protective effects, whereas furosemide actually increased mortality, compared with aminophylline, following induction of myoglobinuric acute renal failure. Therefore, aminophylline's protective effects are independent of tubuloglomerular feedback and natriuresis. These results offer further support for the hypothesis that adenosine-induced hemodynamic changes play a pathogenic role in glycerol-induced acute renal failure in rats.

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