Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels

ABSTRACTIn this article, the literature examining the relationship between testosterone and various cognitive domains in elderly men is reviewed. The review focuses on the role of endogenous testosterone levels and the effects of androgen depletion and replacement. The cognitive domains most commonly linked to testosterone include memory and visuospatial function. Indeed, the literature suggests that in certain conditions (ie, hypogonadism, cognitive impairment) testosterone levels may be significantly associated with memory and visuospatial function, but not other cognitive functions. Studies with larger sample sizes and more sensitive cognitive measures are indicated, as questions remain about the potential role of testosterone as a cognitive enhancer.

Download Full-text

Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels

Thrombosis and Haemostasis ◽

10.1160/th09-02-0090 ◽

2009 ◽

Vol 102 (11) ◽

pp. 945-950 ◽

Cited By ~ 17

Author(s):

Ingvild Agledahl ◽

Johan Svartberg ◽

John-Bjarne Hansen ◽

Ellen Brodin

Keyword(s):

Tissue Factor ◽

Plasma Levels ◽

Thrombin Generation ◽

Ex Vivo ◽

Favorable Effect ◽

Elderly Men ◽

Testosterone Treatment ◽

Testosterone Levels ◽

Low Testosterone ◽

One Year

SummaryMen have a higher incidence of cardiovascular disease (CVD) than women of similar age, and it has been suggested that testosterone may influence the development of CVD. Recently, we demonstrated that elderly men with low testosterone levels had lower plasma levels of free tissue factor pathway inhibitor (TFPI) Ag associated with shortened tissue factor (TF)-induced coagulation initiation in a population based case-control study. Our hypothesis was that one year of testosterone treatment to physiological levels in elderly men would increase the levels of free TFPI Ag in plasma and have a favorable effect on TF-induced coagulation. Twenty-six men with low testosterone levels (≤11.0 nM) were randomly assigned to treatment with intramuscular testosterone depot injections (testosterone undecanoate 1,000 mg) or placebo in a double-blinded study. Each participant received a total of five injections, at baseline, 6, 16, 28 and 40 weeks, and TF-induced thrombin generation ex vivo and plasma free TFPI Ag were measured after one year. At the end of the study total and free testosterone levels were significantly higher in the testosterone treated group (14.9 ± 4.5 nM vs. 8.1 ± 2.4 nM; p<0.001, and 363.3 ± 106.6 pM vs. 187.3 ± 63.2 pM; p<0.001, respectively). Testosterone treatment for one year did neither cause significant changes in TF-induced thrombin generation ex vivo nor changes in plasma levels of free TFPI Ag. In conclusion, normalising testosterone levels by testosterone treatment for 12 months in elderly men did not affect TF-induced coagulation or plasma TFPI levels. The potential antithrombotic role of testosterone therapy remains to be elucidated.

Download Full-text

P3479Mediterranean type of diet and olive oil consumption show beneficial effects on sexual capacity through improvement of aortic elastic properties and testosterone levels in elderly men from IKARIA stud

European Heart Journal ◽

10.1093/eurheartj/ehy563.p3479 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

C Chrysohoou ◽

J Skoumas ◽

G Lazaros ◽

M Zaromytidou ◽

C Masoura ◽

...

Keyword(s):

Olive Oil ◽

Elastic Properties ◽

Oil Consumption ◽

Elderly Men ◽

Testosterone Levels ◽

Beneficial Effects ◽

Aortic Elastic Properties

Download Full-text

Plasma free tissue factor pathway inhibitor (TFPI) levels and TF-induced thrombin generation ex vivo in men with low testosterone levels

Thrombosis and Haemostasis ◽

10.1160/th08-10-0667 ◽

2009 ◽

Vol 101 (03) ◽

pp. 471-477 ◽

Cited By ~ 7

Author(s):

Ingvild Agledahl ◽

Johan Svartberg ◽

Bjarne Hansen ◽

Ellen Brodin

Keyword(s):

Tissue Factor ◽

Thrombin Generation ◽

Tissue Factor Pathway Inhibitor ◽

Ex Vivo ◽

Elderly Men ◽

Lower Plasma ◽

Testosterone Levels ◽

Initiation Phase ◽

Tissue Factor Pathway ◽

Low Testosterone

SummaryLow testosterone levels in men have been associated with cardiovascular risk factors, some prothrombotic factors, and lately also an increased risk of both cardiovascular disease and all-cause mortality. Experimental studies have shown increased synthesis and release of tissue factor pathway inhibitor (TFPI) by physiological levels of testosterone in endothelial cells. Our hypothesis was that elderly men with low testosterone levels would have lower plasma levels of plasma free TFPI with subsequent increased thrombin generation. Elderly men with low (n=37) and normal (n=41) testosterone levels were recruited from a general population, and tissue factor (TF)-induced thrombin generation ex vivo and plasma free TFPI Ag were measured. Elderly men with low testosterone levels had lower plasma free TFPI Ag (10.9 ± 2.3 ng/ml vs. 12.3 ± 3.0 ng/ml, p=0.027) and shorter initiation phase of TF-induced coagulation assessed by lag-time (5.1 ± 1.0 min vs. 5.7 ± 1.3, p=0.039). The differences between groups remained significant and were strengthened after adjustment for waist circumference and other cardiovascular risk factors. Lag-time increased linearly across quartiles of plasma free TFPI Ag (p<0.001). Multiple regression analysis revealed that total and free testosterone were independent predictors of plasma free TFPI Ag. Our findings suggest that low testosterone levels in elderly men is associated with low plasma free TFPI Ag and subsequent shortened initiation phase of TF-induced coagulation.

Download Full-text

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa038 ◽

2020 ◽

Vol 4 (5) ◽

Author(s):

Tinh-Hai Collet ◽

Susan K Ewing ◽

Kristine E Ensrud ◽

Gail A Laughlin ◽

Andrew R Hoffman ◽

...

Keyword(s):

Prospective Study ◽

Sex Hormones ◽

Community Dwelling ◽

Sex Hormone Binding Globulin ◽

Total Testosterone ◽

Continuous Variables ◽

Elderly Men ◽

Sleep Study ◽

Testosterone Levels ◽

Increased Risk

Abstract Context Observational studies show discordant links between endogenous testosterone levels and cardiovascular diseases (CVD). Objective We assessed whether sex hormones and sex hormone–binding globulin (SHBG) are associated with CVD in community-dwelling elderly men. Design, Setting and Participants Prospective study of incident CVD among 552 men ≥ 65 years in the MrOS Sleep Study without prevalent CVD and no testosterone therapy at baseline. Outcomes Fasting serum levels of total testosterone and estradiol were measured using liquid chromatography-mass spectrometry, and SHBG by chemiluminescent substrate. The association of sex hormones and SHBG with incident coronary heart disease (CHD), cerebrovascular (stroke and transient ischemic attack) and peripheral arterial disease (PAD) events were assessed by quartile and per SD increase in proportional hazards models. Results After 7.4 years, 137 men (24.8%) had at least 1 CVD event: 90 CHD, 45 cerebrovascular and 26 PAD. The risk of incident CVD events was not associated with quartiles of baseline sex hormones or SHBG (all P ≥ 0.16). For +1 SD in total testosterone, the multivariate-adjusted hazard ratio was 1.04 (95% CI, 0.80-1.34) for CHD, 0.86 (0.60-1.25) for cerebrovascular, and 0.81 (0.52-1.26) for PAD events. When analyzed as continuous variables or comparing highest to low quartile, levels of bioavailable testosterone, total estradiol, testosterone/estradiol ratio and SHBG were not associated with CVD events. Conclusions In community-dwelling elderly men, endogenous levels of testosterone, estradiol, and SHBG were not associated with increased risk of CHD, cerebrovascular, or PAD events. These results are limited by the small number of events and should be explored in future studies.

Download Full-text