SARCOIDOSIS AND OTHER GRANULOMATOUS DISEASES OF THE LUNG: CLINICAL ASPECTS AND PROBLEMS OF DIFFERENTIAL DIAGNOSIS

1976 ◽  
Vol 278 (1 Seventh Inter) ◽  
pp. 528-531
Author(s):  
A. Blasi ◽  
D. Olivieri ◽  
A. Pezza
Keyword(s):  
Differential Diagnosis ◽  
Clinical Aspects ◽  
Granulomatous Diseases

Benign Paroxysmal Vertigo of Childhood: A Long-Term Follow-Up

Cephalalgia ◽  
1994 ◽  
Vol 14 (6) ◽  
pp. 458-460 ◽  
Author(s):  
G Lanzi ◽  
U Balottin ◽  
E Fazzi ◽  
M Tagliasacchi ◽  
M Manfrin ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Age Of Onset ◽  
Clinical Aspects ◽  
Migrainous Vertigo ◽  
Long Term Follow Up

We examined clinical aspects of Benign Paroxysmal Vertigo (BPV) in infancy and its most frequent differential diagnosis, in particular analogies and differences with forms of “migrainous vertigo” (MV) of later onset. During a long-term follow-up of 7 cases of BPV, diagnosed according to the Basser criteria, 5 of 7 BPV cases spontaneously resolved and 6 of 7 patients later developed migraine and other migraine-related symptoms. This course differs from that described for MV only in the age of onset of headache and in the chronological relationship with vertigo. The authors suggest that BPV can be interpreted as a migraine precursor and MV as a migraine equivalent.

Beckwith-Wiedemann Syndrome

2019 ◽  
pp. 39-72
Author(s):  
Alessandro Mussa ◽  
Jennifer M. Kalish ◽  
Flavia Cerrato ◽  
Andrea Riccio ◽  
Giovanni Battista Ferrero
Keyword(s):  
Differential Diagnosis ◽  
In Vitro Fertilization ◽  
Diagnostic Criteria ◽  
Clinical Aspects ◽  
Molecular Pathways ◽  
Vitro Fertilization ◽  
Imprinting Disorders ◽  
Risk Of Malignancy ◽  
Overgrowth Syndromes

This chapter provides a thorough overview of Beckwith-Wiedemann syndrome, which is considered to be the most common of the overgrowth syndromes and imprinting disorders. It starts with a description of the clinical aspects of the condition, including diagnostic criteria, differential diagnosis, risk of malignancy, and management. This is followed by an in-depth description of the genetic causes of the syndrome and of the molecular pathways involved in the pathogenesis of this disorder. The complexities of the etiology, which involves two neighboring loci, each one regulated by finely tuned imprinting mechanisms, are clearly delineated. The chapter also touches on the reported association between in vitro fertilization and risk of conceiving a baby with this syndrome.

Oral hairy leukoplakia: Clinical aspects, histologic morphology and differential diagnosis

Head & Neck ◽  
1991 ◽  
Vol 13 (6) ◽  
pp. 514-521 ◽  
Author(s):  
Giuseppe Ficarra ◽  
Domenico Gaglioti ◽  
Massimo Di Pietro ◽  
Karen Adler-Storthz
Keyword(s):  
Differential Diagnosis ◽  
Clinical Aspects ◽  
Oral Hairy Leukoplakia ◽  
Hairy Leukoplakia

scholarly journals Nodal tuberculosis on positron emission tomography/computed tomography with 18F-Fluordexosiglucose, a case report

ANALES RANM ◽  
2021 ◽  
Vol 138 (138(02)) ◽  
pp. 183-185
Author(s):  
M.K. Meneses Navas ◽  
P. Romero Fernández ◽  
M.N. Cabrera Martín ◽  
A. Ortega Candil ◽  
J.L. Carreras Delgado
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Differential Diagnosis ◽  
Lymph Node ◽  
Malignant Tumors ◽  
Emission Tomography ◽  
Axial Tomography ◽  
Positron Emission ◽  
Lymph Node Tuberculosis ◽  
Granulomatous Diseases

Tuberculosis is an infectious disease, caused by the Mycobacterium tuberculosis bacillus. Extrapulmonary disease can cause nonspecific symptoms and signs, which makes diagnostic suspicion difficult. We present the case of a man with a history of cancer in complete remission, diagnosed with lymph node tuberculosis, after being admitted to our hospital due to fever, dyspnea, and central chest pain. A Positron Emission Tomography / Computed Axial Tomography with 18F-fluordexosiglucose is requested; which showed multiple mediastinal adenopathic conglomerates with intense radiotracer uptake, suggesting ruling out malignancy. Active lymph node tuberculosis will show increased metabolic activity with Positron Emission Tomography / Computed Tomography with 18F-fluordexosiglucose, which could make the differential diagnosis with malignant tumors or other granulomatous diseases difficult, as in the case of our patient. Therefore, it is important to consider lymph node tuberculosis as a differential diagnosis in patients with adenopathies suspected of malignancy.

scholarly journals Leishmaniose visceral: Uma revisão literária

2016 ◽  
Vol 6 (2) ◽  
pp. 35
Author(s):  
Antonio Ricardo Lisboa ◽  
Anderson Angel Vieira Pinheiro ◽  
Antonia Elinaíde Ferreira Dantas ◽  
Itatyane Batista de Oliveira ◽  
Tiago Rozendo Evangelista ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Web Of Science ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Epidemiological Data ◽  
Laboratory Diagnosis ◽  
New Drugs ◽  
Clinical Aspects ◽  
Appropriate Treatment ◽  
Main Host

<p>A leishmaniose é uma zoonose relatada principalmente em países de clima tropical e sistêmica transmitida por flebotomínios. Por ser uma zoonose que afeta tanto o homem quanto os animais e, recentemente, um grande aumento dos seus dados epidemiológicos, objetivou-se estabelecer uma revisão desde aspectos clínico-epidemiológicos até os novos estudos que visam novas substâncias para o tratamento da doença. Para tanto, a literatura consultada se deu a partir do uso do Scopus, PubMed, Web of Science, Periódicos CAPES e bibliotecas acadêmicas. Estudos mostraram os aspectos clínicos que a zoonose acarreta e os dados epidemiológicos do nosso país. No Brasil, a forma infectante é a <em>Leishmania (L.) chagasi</em>, sendo que para diagnóstico diferencial, utiliza-se de artifícios bioquímicos, imunológicos e/ou anatomopatológicos. Até o momento as espécies <em>Lutzomyia</em> <em>longipalpis </em>e <em>Lutzomyia cruzi</em> estão relacionadas com a transmissão da doença no Brasil. O principal hospedeiro é o cão (<em>Canis familiares</em>) e é a maior fonte de transmissão do parasito para o homem. O diagnóstico laboratorial continua pautado em parasitológico, imunológico/munofluorescência e ELISA. O clínico se baseia em sinais e sintomas, compilados com os laboratoriais. O tratamento se baseia em apenas dois medicamentos: o antimoniato de N-metil glucamina e a anfotericina B. Desta forma, se faz necessário o investimento para estudos e desenvolvimento de novas drogas, sejam elas derivadas de produtos naturais ou sintéticas e de vacinas para humanos que possam atuar frente a esta zoonose, uma vez que, já se tem observado resistência aos fármacos utilizados. Medidas que visam a redução da transmissão são fundamentais, bem como, o diagnóstico precoce e de alta sensibilidade dos cães infectados para iniciar o tratamento adequado. </p><p align="center"><strong><em>Visceral leishmaniasis: A literary review</em></strong></p><p><strong>Abstract: </strong><em>The leishmaniasis is a zoonosis systemic reported mainly in countries with a tropical climated and transmitted by phlebotomines. For being a zoonosis which affects both the man as the animals and, recently, a large increase in its epidemiological data, ruled in establishing a review from clinical-epidemiological aspects until the new studies that aim new substances for the treatment of the disease. Therefore, a literature consulted it was based on the use of </em>Scopus, PubMed, Web of Science, “CAPES” periodicals and academic bibliography. Studies have shown the clinical aspects that the zoonosis entails and the epidemiological data of our country. In Brazil, <em>Leishmania</em> (L.) <em>chagasi</em> is the infecting form, being that for differential diagnosis, it uses biochemical, immunological and /or anatomopathological devices. To date the <em>Lutzomyia</em><em> longipalpis</em> and <em>Lutzomyia cruzi</em> species are related to the transmission of the disease in Brazil. The main host is the dog (<em>Canis familiares</em>) and is the major source of transmission of the parasite for man. The laboratory diagnosis is based on parasitological, immunological / munofluorescence and ELISA. The clinician relies on signs and symptoms, compiled with the laboratory. The treatment is based on only two drugs: antimoniate n-methyl-<em>D</em>-glucamine and amphotericin B. Therefore, is necessary to invest in studies and development of new drugs, whether they are derived from natural product or synthetic and from vaccines for humans that may act against this zoonosis, since, resistance to the drugs used has already been observed. Measures aimed at reducing transmission are essential, as well as, the early and high sensitivity diagnosis of infected dogs to initiate appropriate treatment.</p>

scholarly journals Diagnosis of Pemphigus associated with canine Leishmaniosis: a Case Report

2021 ◽  
Vol 1 (2) ◽  
pp. 45-52
Author(s):  
Marilene da Silva Marques ◽  
Érico do Nascimento Arruda ◽  
Aline Maia Silva
Keyword(s):  
Differential Diagnosis ◽  
Histopathological Examination ◽  
Immunosuppressive Treatment ◽  
Canine Leishmaniasis ◽  
Clinical Aspects ◽  
Canine Leishmaniosis ◽  
Biochemical Tests ◽  
Therapeutic Success ◽  
Dermatological Condition ◽  
Leishmania Spp

Pemphigus is an autoimmune dermatological condition that affects dogs and has in its clinical aspects a similarity to leishmaniasis, in which a differential diagnosis by means of histopathological examination is necessary. The present study sought to report a case of a dog, male, mixed breed, 10 years old, diagnosed with pemphigus and, later, diagnosed with leishmaniosis. Upon diagnosis, the animal presented only a lesion in the nasal plane, without apathy and without systemic changes, as evidenced by hematological and biochemical tests. After performing histopathological examination, the animal was diagnosed with pemphigus and underwent immunosuppressive treatment, obtaining significant improvement of the lesion. Under clinical suspicion of leishmaniasis, the animal was subjected to serological exams RIFI and ELISA resulting in an indeterminate result in ELISA and 1/40 reagent in the RIFI. As this is not a very relevant result, it was decided to perform another histopathological examination of the lesion where the presence of Leishmania spp. In this new exam it was not possible to obtain a diagnosis of pemphigus again, since the animal was under immunosuppressive treatment. Therefore, it is concluded that, in cases of co-infection of autoimmune diseases, such as pemphigus and canine leishmaniasis, the differential diagnosis by means of histopathological examination is extremely relevant to the patient's therapeutic success and prognosis. Thus, it is necessary to note that the diagnosis of pemphigus does not exclude the diagnosis of leishmaniosis.

scholarly journals New laboratory criterion for the differential diagnosis of sarcoidosis and pulmonary tuberculosis

2020 ◽  
Author(s):  
Anna Starshinova ◽  
Anna Malkova ◽  
Yulia Zinchenko ◽  
Natalia Basantsova ◽  
Igor Kudryavtsev ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Tuberculosis ◽  
X Ray ◽  
Healthy Donors ◽  
Significant Difference ◽  
Laboratory Features ◽  
Citrullinated Vimentin ◽  
Cell Subpopulations ◽  
N 93 ◽  
Granulomatous Diseases

Abstract In some cases there is a problem of differential diagnosis of sarcoidosis (SD) and tuberculosis (TB) because of the similarities in clinical, X-ray and laboratory features. The aim of this study was to search for new differential diagnostic criteria for sarcoidosis and tuberculosis by calculating the index, based on the level of autoantibodies to modified citrullinated vimentin (anti-MCV) and the level of B-cell subpopulations. These parameters were measured in patients with sarcoidosis (n = 93), tuberculosis (n = 28) and healthy donors (n = 40) using the ELISA and cytometry. The absence of a statistically significant difference when comparing the level of anti-MCV, the number of B-cells in SD and TB suggests that these changes may be characteristic of granulomatous diseases. The use of the formula Ds=([B-naïve%]\[B-memory%])*([B-CD38%]+[B-CD5%])/[anti-MCV] might allow to differentiate SD with an increase in the calculated index of more than 5 units with a sensitivity of 80.00% and specificity of 93.10% (AUC = 0.926).

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