Purpose:
Hyperhomocysteinemia (HHcy) has been considered a risk factor for different diseases including cardiovascular
disease (CVD), inflammation, neurological diseases, cancer and many other pathological conditions. Likewise,
arachidonic acid (AA) metabolism is implicated in both vascular homeostasis and inflammation as shown by the development
of CVD following the imbalance of its metabolites.
Aim of The Review:
This review summarizes how homocysteine (Hcy) can influence the metabolism of AA.
Methods:
In silico literature searches were performed on PubMed and Scopus as main sources.
Results:
Several studies have shown that altered levels of Hcy, through AA release and metabolism, can influence the synthesis
and the activity of prostaglandins (PGs), prostacyclin (PGI₂), thromboxane (TXA), epoxyeicosatrienoic acids (EETs)
and hydroxyeicosatetraenoic acids (HETEs).
Conclusions:
We believe that by targeting Hcy in AA pathways, novel compounds with better pharmacological and pharmacodynamics
benefits may be obtained and that this information is valuable for dietician to manipulate diets to improve
health.
Use of Metabolomic Profiling in the Study of Arachidonic Acid Metabolism in Cardiovascular Disease
