A CLOSED SYSTEM SAMPLE TRANSFER DEVICE FOR VOLATILE ORGANIC COMPOUNI)S
            1

Purpose The purpose of this study was to test the efficacy of ChemfortTM, an air filtration closed-system drug transfer device to prevent release of chemotherapy drug vapors and aerosols under extreme conditions. The air cleaning system is based on the adsorption of drug vapors by an activated carbon filter in the Vial Adaptor before the air is released out of the drug vial. The functionality of the carbon filter was also tested at the end of device’s shelf life, and after a contact period with drug vapors for 7 days. Cyclophosphamide and 5-fluorouracil were the chemotherapy drugs tested. Methods The Vial Adaptor was attached to a drug vial and both were placed in a glass vessel. A needle was punctured through the vessel stopper and the Vial Adaptor septum to allow nitrogen gas to flow into the vial and to exit the vial via the air filter into the glass vessel which was connected to a cold trap. Potential contaminated surfaces in the trap system were wiped or rinsed to collect the escaped drug. Samples were analyzed using liquid chromatography tandem mass spectrometry. Results Cyclophosphamide and 5-fluorouracil were detected on most surfaces inside the trap system for all Vial Adaptors without an activated carbon filter. Contamination did not differ between the Vial Adaptors with and without membrane filter indicating no effect of the membrane filter. The results show no release of either drug for the Vial Adaptors with an activated carbon filter even after 3 years of simulated aging and 7 days of exposure to drug vapors. Conclusions Validation of air cleaning CSTDs is important to secure vapor and aerosol containment of chemotherapy and other hazardous drugs. The presented test method has proven to be appropriate for the validation of ChemfortTM Vial Adaptors. No release of cyclophosphamide and 5- fluorouracil was found even for Vial Adaptors after 3 years of simulated aging and 7 days of exposure to drug vapors.

Download Full-text

6ER-026 Reduction in contamination with antibiotics on surfaces and in environmental air in nursing departments in three hospitals following implementation of a closed-system drug transfer device

10.1136/ejhpharm-2018-eahpconf.518 ◽

2018 ◽

Author(s):

P Sessink

Keyword(s):

Closed System ◽

Drug Transfer ◽

Environmental Air ◽

Transfer Device

Download Full-text

Pre and post intervention study of antiblastic drugs contamination surface levels at a Pharmacy Department Compounding Area using a closed system drug transfer device and a decontamination process

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2018.03.001 ◽

2018 ◽

Vol 95 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Silvia Valero ◽

Eduardo López-Briz ◽

Nieves Vila ◽

Antonio Solana ◽

Mar Melero ◽

...

Keyword(s):

Closed System ◽

Intervention Study ◽

Post Intervention ◽

Drug Transfer ◽

Pharmacy Department ◽

Transfer Device

Download Full-text

Modifications Needed for Performing High-Resolution Cryosem in a Hitachi S-4700 Fesem Using an Emitech K1250 Cryo-Preparation System

Microscopy and Microanalysis ◽

10.1017/s1431927600029676 ◽

2001 ◽

Vol 7 (S2) ◽

pp. 720-721

Author(s):

Ya Chen ◽

Chris Frethem ◽

Stanley L. Erlandsen

Keyword(s):

High Resolution ◽

Thermal Contact ◽

Control Unit ◽

Thermal Capacity ◽

Electron Beam Evaporation ◽

Sample Holder ◽

Sputter Coating ◽

Magnetron Sputter ◽

Sample Transfer ◽

Transfer Device

Cryo-techniques have been successfully used in scanning electron microscopy (SEM). They are especially promising for high-resolution SEM to improve specimen preservation and reduce radiation damage [1, 2]. A number of cryo-preparation systems are commercially available for SEM, however, our experience has shown that modifications are needed to perform highresolution imaging (>50,000x).Emitech K1250 system consists of a sample preparation chamber, control unit, and cryo-stage. Magnetron sputter coating is standard and electron-beam evaporation is optional. A vacuum transfer device facilitates the sample transfer between the preparation chamber and the SEM to prevent contamination. The Emitech cryo-stage replaces the Hitachi S-4700 standard stage and the cryo-stage temperature is monitored and controlled by the Emitech control unit.The specimen is mounted on a sample holder that mounts to the cryo-stage. Therefore, the distance from the specimen to cryo-stage, the thermal capacity of the sample holder, and the thermal contact between them will affect the actual temperature of the specimen.

Download Full-text