High‐fat consumption alters the gut microbiome in retinitis pigmentosa mice and accelerates retinal degeneration

A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state, oxidative stress, and gut microbiome in dystrophic retinal degeneration 10 (rd10) mice, a model of retinitis pigmentosa, fed an HFD for 2 to 3 wk. Short-term HFD feeding impaired retinal responsiveness and visual acuity and enhanced photoreceptor degeneration, microglial cell activation, and Müller cell gliosis. HFD consumption also triggered the expression of inflammatory and oxidative markers in rd10 retinas. Finally, an HFD caused gut microbiome dysbiosis, increasing the abundance of potentially proinflammatory bacteria. Thus, HFD feeding drives the pathological processes of retinal degeneration by promoting oxidative stress and activating inflammatory-related pathways. Our findings suggest that consumption of an HFD could accelerate the progression of the disease in patients with retinal degenerative disorders.

Download Full-text

Acute high‐fat feeding exacerbates retinal degeneration in a mice model of retinitis pigmentosa

Acta Ophthalmologica ◽

10.1111/aos.13972_261 ◽

2018 ◽

Vol 96 (S261) ◽

pp. 72-72

Keyword(s):

Retinitis Pigmentosa ◽

Retinal Degeneration ◽

Mice Model ◽

High Fat ◽

Fat Feeding

Download Full-text

Amplitude and Latency of Electroretinographical Peaks as a tool to Predict the Extent of Retinal Degeneration in Retinitis Pigmentosa Patients

http://www.fortunejournals.com/journal-of-ophthalmology-and-research-home-fjor.php ◽

10.26502/fjor.2644-00240024 ◽

2020 ◽

Vol 03 (03) ◽

Author(s):

Maryam Naser ◽

Seyed Mohammad Masoud Shushtarian

Keyword(s):

Retinitis Pigmentosa ◽

Retinal Degeneration

Download Full-text

Retinitis pigmentosa is associated with shifts in the gut microbiome

Scientific Reports ◽

10.1038/s41598-021-86052-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Oksana Kutsyr ◽

Lucía Maestre-Carballa ◽

Mónica Lluesma-Gomez ◽

Manuel Martinez-Garcia ◽

Nicolás Cuenca ◽

...

Keyword(s):

Retinitis Pigmentosa ◽

Gut Microbiome ◽

Functional Decline ◽

Retinal Disease ◽

Photoreceptor Cells ◽

Amplicon Sequencing ◽

Rrna Gene ◽

Sequencing Data ◽

Alpha And Beta Diversity ◽

Potential Biomarker

AbstractThe gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP). Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice. In rd10 mice, retinal responsiveness to flashlight stimuli and visual acuity were deteriorated with respect to observed in age-matched control mice. This functional decline in dystrophic animals was accompanied by photoreceptor loss, morphologic anomalies in photoreceptor cells and retinal reactive gliosis. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. Remarkably, four fairly common ASV in healthy gut microbiome belonging to Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp. were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with RP. The results indicate that retinal degenerative changes in RP are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases.

Download Full-text

Gut microbiome alterations in high-fat-diet-fed mice are associated with antibiotic tolerance

Nature Microbiology ◽

10.1038/s41564-021-00912-0 ◽

2021 ◽

Author(s):

Yuan Liu ◽

Kangni Yang ◽

Yuqian Jia ◽

Jingru Shi ◽

Ziwen Tong ◽

...

Keyword(s):

Gut Microbiome ◽

High Fat Diet ◽

Antibiotic Tolerance ◽

High Fat

Download Full-text

Postnatally induced metabolic and oxidative changes associated with maternal high-fat consumption were mildly affected by Quercetin-3-O-rutinoside treatment in rats

Heliyon ◽

10.1016/j.heliyon.2021.e06847 ◽

2021 ◽

Vol 7 (4) ◽

pp. e06847

Author(s):

Toluwalope E. Adeyemi ◽

Duyilemi C. Ajonijebu ◽

Mahendra L. Channa ◽

Anand Nadar

Keyword(s):

High Fat ◽

Fat Consumption

Download Full-text

Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet

Genome Medicine ◽

10.1186/s13073-016-0297-9 ◽

2016 ◽

Vol 8 (1) ◽

Cited By ~ 85

Author(s):

Douglas Mahana ◽

Chad M. Trent ◽

Zachary D. Kurtz ◽

Nicholas A. Bokulich ◽

Thomas Battaglia ◽

...

Keyword(s):

Insulin Resistance ◽

Liver Disease ◽

Gut Microbiome ◽

High Fat Diet ◽

High Fat

Download Full-text

Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis

Food & Function ◽

10.1039/d1fo03147c ◽

2022 ◽

Author(s):

Ying Lan ◽

Qingyang Sun ◽

Zhiyuan Ma ◽

Jing Peng ◽

Mengqi Zhang ◽

...

Keyword(s):

Gut Microbiota ◽

Gut Microbiome ◽

High Fat Diet ◽

High Fat ◽

Diet Induced Obesity

Obesity has been reported to be associated with gut microbiome dysbiosis. seabuckthorn fruits are traditionally used in Tibetan foods and medicines for thousands of years. Seabuckthorn polysaccharide (SP) is one...

Download Full-text

132 Early Establishment of the Human Gut Microbiome—a Tale of Moms, Their Diets, and Babes Guts

Journal of Animal Science ◽

10.1093/jas/skab235.123 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 68-68

Author(s):

Kjersti M Aagaard

Keyword(s):

Gut Microbiome ◽

Maternal Obesity ◽

Maternal Diet ◽

Dietary Exposure ◽

Metabolic Phenotype ◽

Strong Impact ◽

High Fat ◽

Lower Genital Tract ◽

And Function ◽

The Impact

Abstract Human microbial communities are characterized by their metagenomic and metabolic diversity, which varies by distinct body sites and influences human physiology. We are only beginning to characterize the complex set of interactions which alters both community membership and function in early development. With respect to the potential source of microbiota at birth, it has been generally assumed that the majority of seeding microbes originate from the maternal lower genital tract, with microbiota ascending into the otherwise sterile intrauterine. However, we and subsequently others have recently demonstrated that (1) the vaginal and gut microbiome communities are distinctly structured in pregnancy, and (2) the intrauterine environment and the fetus is in fact not sterile, but rather harbors a low-abundance microbiome which varies by several measured exposures, and (3) the maternal diet during both gestation and lactation, and notably a high fat diet, has a particularly strong impact on the developing and early in life microbial community structure. We have taken two dynamic approaches to answering these questions in our studies. First, we use large and robust longitudinal cohorts of maternal-infant dyads collected across gestation and into infancy to gain deeper insight into both source and sink of the early developmental microbiome and its role on determining length of gestation. Second, we utilize our well established primate models of maternal high fat dietary exposure, both in the absence and presence of maternal obesity, to determine the impact of maternal diet on both the microbiome and the resultant offspring metabolic phenotype.

Download Full-text