Clinical Assessment of Blood Glucose Homeostasis in Horses: Comparison of a Continuous Glucose Monitoring System with a Combined Intravenous Glucose and Insulin Test Protocol

2010 ◽  
Vol 25 (1) ◽  
pp. 162-165 ◽  
Author(s):  
P.J. Johnson ◽  
C.E. Wiedmeyer ◽  
A. LaCarrubba ◽  
N.T. Messer ◽  
H.A. Dingfelder ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Glucose Homeostasis ◽  
Clinical Assessment ◽  
Glucose Monitoring ◽  
Test Protocol ◽  
Intravenous Glucose ◽  
Insulin Test ◽  
Blood Glucose Homeostasis

scholarly journals Continuous Glucose Monitoring System Versus Self-Monitoring Blood Glucose in Type 1 Diabetes Mellitus Children: A Randomised Controlled Trial (RoSEC)

2021 ◽  
Vol 27 (2) ◽  
pp. 51-68
Author(s):  
Muhd Alwi Muhd Helmi ◽  
Norsa'adah Bachok ◽  
Suhaimi Hussain
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycaemic Control ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Controlled Trial ◽  
Glucose Monitoring ◽  
Control Group ◽  
Self Monitoring ◽  
The Mean

Objectives: The primary and secondary objectives were to compare the glycaemic control and frequency of hypoglycaemia between continuous glucose monitoring system (CGMS) and self-monitoring blood glucose (SMBG). Methods: A single centre, randomised, parallel-group controlled trial was conducted involving twenty-two type one Diabetes Mellitus (T1DM) patients with the mean age of 13.8 years assigned to either intervention or control group. All respondents wore the CGMS device at the beginning of the study. Intervention group (n=11) had their insulin adjusted based on the CGMS data, while the control group (n=11) was based on SMBG. Monthly average blood sugar level (BSL) and monthly mean hypoglycemic events per week (HE/wk) were measured at baseline, first month, second month, and third month. HbA1c levels were measured at baseline and in the third month. Results: The baseline characteristics were similar. The data were analysed using repeated measure analysis of variance (ANOVA). The mean difference of HbA1c within the group was not statistically significant with p=0.322. There were significant differences in the monthly mean HE/wk within and between groups, p=0.004, and p=0.037. Conclusion: In conclusion, CGMS is equivalent to SMBG in optimising glycaemic control but is more effective in detecting hypoglycaemia in children.  

scholarly journals Assessment of a Noninvasive Chronic Glucose Monitoring System in Euglycemic and Diabetic Swine (Sus scrofa)

2020 ◽  
Author(s):  
Rebecca A Ober ◽  
Gail E Geist
Keyword(s):  
Blood Glucose ◽  
Monitoring System ◽  
Continuous Glucose Monitoring ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Continuous Glucose Monitoring System ◽  
Serum Chemistry ◽  
Continuous Glucose Monitor ◽  
Glucose Levels ◽  
Skin Patch

Models of type-I diabetes are well-characterized and commonly used in the preclinical evaluation of drugs and medical devices. The diabetic minipig is an excellent example of a translational model. However, chronic glucose monitoring in this species can be challenging; frequent blood sampling can be technically difficult and poorly tolerated in conscious swine. Skin-patch continuous blood glucose monitors are FDA-approved for human use and offer a potential refinement to cageside blood collection. However, this modality has not been evaluated in pigs. In this study, young adult male STZ-induced diabetic Yucatan minipigs (n = 4) and healthy York pigs (n = 4) were implanted with a 14-d skin-patch continuous glucose monitor. Readings from continuous glucose monitors were time-matched to whole blood samples, with glucose measurements performed using point-of-care blood glucose monitors, serum chemistry or both. The aims of the study were to assess if a continuous glucose monitoring system could accurately detect glucose levels in swine, and to compare the readings toboth point-of-care glucometers and serum chemistry results. We hypothesized that a continuous glucose monitoring system would accurately detect glucose levels in swine in comparison with a validated analyzer and could serve as an animal welfarerefinement for studies of diabetes. We found that the continuous glucose monitor used in this study provided an adequateadjunct for clinical management in the stable diabetic pig and a minimally invasive and inexpensive option for colony maintenanceof chronically diabetic swine.

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