The inhibitory action of zinc sulphate on the contractile activity of guinea-pig ileum

1991 ◽  
Vol 43 (4) ◽  
pp. 294-296 ◽  
Author(s):  
C. H. Cho ◽  
G. W. Teh
Keyword(s):  
Guinea Pig ◽  
Inhibitory Action ◽  
Zinc Sulphate ◽  
Contractile Activity ◽  
Guinea Pig Ileum

Antihistaminic activity of Ethanolic extract of Capparis moonii W. fruit.

2021 ◽  
pp. 4403-4407
Author(s):  
Priya Gupta ◽  
Vanita Kanase
Keyword(s):  
Guinea Pig ◽  
Contractile Activity ◽  
Ethanolic Extract ◽  
Toxicity Tests ◽  
Tissue Preparation ◽  
Guinea Pig Ileum ◽  
Oral Toxicity ◽  
Chlorpheniramine Maleate ◽  
Antihistamine Activity ◽  
Different Doses

The purpose of the present work were intended to determine the antihistaminic activity of ethanolic extract of Capparis moonii W. fruits (EECM). Capparis moonii W. had been historically used in the diagnosis of cough and asthma and so we undertook this study to validate scientifically using appropriate animal models. Antihistamine is considered to be helpful for the treatment of allergic, thus, the antihistamine activity of an ethanolic extract of Capparis moonii W. in the current work was evaluated. To determine the doses, acute oral toxicity tests were conducted. Clonidine and haloperidol that induced cataleptic effect in Swiss albino mice were evaluated for antihistaminic activity at the different doses of 50mg/kg, 100mg/kg and 200mg/kg, p.o. and the evaluation is also done on guinea pig ileum tissue. The ethanolic extract of Capparis moonii W. fruits (50, 100, 200mg/kg, p.o.) and chlorpheniramine maleate (i.p.,10mg/kg) significantly inhibited (****P<0.0001) clonidine induced catalepsy but the extract donot inhibit haloperidol-induced catalepsy and histamine-induced contraction in guinea pig ileum tissue preparation shows that ethanolic extract of Capparis moonii W. inhibited the contractile activity of histamine. The result of our work shows that the ethanolic extract possesses antihistaminic activity. It can be reported that flavonoid present in the extract may be important for an antihistaminic effect and therefore may have a role in the asthma treatment.

Effect of morphine and acetylcholine on contractile activity and cyclic AMP in guinea-pig ileum

1990 ◽  
Vol 10 (1) ◽  
pp. 113-119 ◽  
Author(s):  
L. F. Alguacil ◽  
M. P. Lopez-Ruiz ◽  
J. C. Prieto ◽  
C. Alamo ◽  
E. Cuenca
Keyword(s):  
Electrical Stimulation ◽  
Guinea Pig ◽  
Prolonged Exposure ◽  
Contractile Activity ◽  
Inhibitory Effect ◽  
Guinea Pig Ileum ◽  
Camp Content ◽  
Twitch Response ◽  
Spontaneous Movements ◽  
Camp Levels

Neither acute nor prolonged exposure to morphine altered cAMP content or spontaneous movements of longitudinal muscle-myenteric plexus strips of the guinea-pig ileum. By contrast, exogenous acetylcholine or electrical stimulation of the strips elicited both a decrease of cAMP concentration and a twitch response. Atropine blocked the effects of stimulation on these parameters. Addition of morphine to electrically stimulated strips inhibited the twitch response but did not affect cAMP levels. Incubation with morphine led to the development of tolerance to the inhibitory effect on twitch activity and prevented the fall in cAMP normally elicited by electrical stimulation. These results suggest that muscarinic activation is associated with a reduction of cAMP content, an effect which would be impaired in opiate-tolerant tissues.

Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum

1986 ◽  
Vol 128 (3) ◽  
pp. 273-276 ◽  
Author(s):  
Marcello Tonini ◽  
Luciano Onori ◽  
Carlo Alessandro Rizzi ◽  
Fabrizio De Ponti ◽  
Emilio Perucca ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inhibitory Action ◽  
Guinea Pig Ileum

Alpha-2A adrenoceptor subtypes modulate cholinergic contractile activity of guinea-pig ileum

1992 ◽  
Vol 26 ◽  
pp. 321
Author(s):  
Corrado Blandizzi ◽  
Gianfranco Natale ◽  
Mario Del Tacca
Keyword(s):  
Guinea Pig ◽  
Contractile Activity ◽  
Guinea Pig Ileum
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