Thrombus in the left atrial appendage in patients with atrial fibrillation treated with non‐vitamin K antagonist oral anticoagulants in clinical practice—A multicenter registry

2020 ◽  
Vol 31 (8) ◽  
pp. 2005-2012
Author(s):  
Iwona Gorczyca ◽  
Anna Michalska ◽  
Magdalena Chrapek ◽  
Monika Budnik ◽  
Katarzyna Starzyk ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Vitamin K ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Vitamin K Antagonist ◽  
Atrial Appendage ◽  
Multicenter Registry

scholarly journals Outcomes of left atrial appendage occlusion vs. non-vitamin K antagonist oral anticoagulants in atrial fibrillation

2022 ◽  
Author(s):  
Wern Yew Ding ◽  
José Miguel Rivera-Caravaca ◽  
Elnara Fazio-Eynullayeva ◽  
Paula Underhill ◽  
Dhiraj Gupta ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vitamin K ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Vitamin K Antagonist ◽  
Atrial Appendage ◽  
Research Network ◽  
Suitable Alternative ◽  
Left Atrial Appendage Occlusion

Abstract Background The effects of left atrial appendage (LAA) occlusion compared to non-vitamin K antagonist oral anticoagulant (NOAC) therapy in patients with atrial fibrillation (AF) remain unknown. Aims We aimed to evaluate the outcomes in patients with AF who received LAA occlusion vs. NOAC therapy. Methods We utilised data from TriNetX which is a global federated health research network currently containing data for 88.5 million patients. ICD-10 codes were employed to identify AF patients treated with either LAA occlusion or NOAC between 1st December 2010 and 17th January 2019. Clinical outcomes of interest were analysed up to 2 years. Results 108,697 patients were included. Patients who underwent LAA occlusion were younger, more likely to be white Caucasian and male, had a greater incidence of comorbidities, and were less likely to be prescribed other cardiovascular medications. Using propensity score matching, the risk of all-cause mortality was significantly lower among patients who received LAA occlusion compared to NOAC therapy [1.51% vs. 5.60%, RR 0.27 (95% CI 0.14–0.54)], but there were no statistical differences in the composite thrombotic or thromboembolic events [8.17% vs. 7.72%, RR 1.06 (95% CI 0.73–1.53)], ischaemic stroke or TIA [4.69% vs. 5.45%, RR 0.86 (95% CI 0.54–1.38)], venous thromboembolism [1.66% vs. 1.51%, RR 1.10 (95% CI 0.47–2.57)] and intracranial haemorrhage [1.51% vs. 1.51%, RR 1.00 (95% CI 0.42–2.39)]. Conclusion Overall, LAA occlusion might be a suitable alternative to NOAC therapy for stroke prevention in patients with AF. Graphical abstract

Percutaneous left atrial appendage closure versus non-vitamin K oral anticoagulants in patients with non-valvular atrial fibrillation and high bleeding risk

2020 ◽  
Vol 15 (17) ◽  
pp. 1548-1554 ◽  
Author(s):  
Cosmo Godino ◽  
Francesco Melillo ◽  
Barbara Bellini ◽  
Mattia Mazzucca ◽  
Carlo Andrea Pivato ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vitamin K ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Bleeding Risk ◽  
Atrial Appendage ◽  
Left Atrial Appendage Closure ◽  
High Bleeding Risk

scholarly journals Does the CHA2DS2-VASc scale sufficiently predict the risk of left atrial appendage thrombus in patients with diagnosed atrial fibrillation treated with non-vitamin K oral anticoagulants?

Medicine ◽  
2020 ◽  
Vol 99 (25) ◽  
pp. e20570
Author(s):  
Anna Michalska ◽  
Iwona Gorczyca ◽  
Magdalena Chrapek ◽  
Agnieszka Kapłon-Cieślicka ◽  
Beata Uziębło-Życzkowska ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vitamin K ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Oral Anticoagulants ◽  
Atrial Appendage ◽  
Left Atrial Appendage Thrombus

scholarly journals Finding Closure: The First WATCHMAN Device in the English-Speaking Caribbean

2020 ◽  
Author(s):  
Richard Ramsingh ◽  
Shelly Juman ◽  
Muhammad Ibrahim ◽  
Risshi Rampersad
Keyword(s):  
Atrial Fibrillation ◽  
Vitamin K ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Vitamin K Antagonist ◽  
Atrial Appendage ◽  
Nonvalvular Atrial Fibrillation ◽  
First Case ◽  
Watchman Device ◽  
English Speaking

The left atrial appendage is an important source of thromboembolism and stroke in patients with nonvalvular atrial fibrillation. Mechanical closure with WATCHMAN has been proven as an effective alternative to Vitamin K antagonist anticoagulation for stroke prophylaxis. We report the first case of this technology in the English-speaking Caribbean.

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