scholarly journals The detrimental effect of iron on OA chondrocytes: Importance of pro‐inflammatory cytokines induced iron influx and oxidative stress

2021 ◽  
Author(s):  
Xingzhi Jing ◽  
Ting Du ◽  
Tao Li ◽  
Xiaoxia Yang ◽  
Guodong Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Detrimental Effect ◽  
Oa Chondrocytes ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

The protective effects of carvacrol and thymol against paracetamol–induced toxicity on human hepatocellular carcinoma cell lines (HepG2)

2016 ◽  
Vol 35 (12) ◽  
pp. 1252-1263 ◽  
Author(s):  
SS Palabiyik ◽  
E Karakus ◽  
Z Halici ◽  
E Cadirci ◽  
Y Bayir ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Hepg2 Cells ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
High Dose ◽  
Protective Effects ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

Acetaminophen (APAP) overdose could induce liver damage and lead to acute liver failure. The treatment of APAP overdoses could be improved by new therapeutic strategies. Thymus spp., which has many beneficial effects and has been used in folk medicine, is one such potential strategy. In the present study, the hepatoprotective activity of the main constituents of Thymus spp., carvacrol and thymol, were evaluated in light of APAP-induced hepatotoxicity. We hoped to understand the hepatoprotective mechanism of these agents on the antioxidant system and pro-inflammatory cytokines in vitro. Dose-dependent effects of thymol and carvacrol (25, 50, and 100 µM) were tested on cultured HepG2 cells. N-Acetylcysteine (NAC) was tested as positive control. We showed that APAP inhibited HepG2 cell growth by inducing inflammation and oxidative stress. Incubating APAP-exposed HepG2 cells with carvacrol and thymol for 24 h ameliorated this inflammation and oxidative stress. We also evaluated alanine transaminase and lactate dehydrogenase levels of HepG2 cells. We found that thymol and carvacrol protected against APAP-induced toxicity in HepG2 cells by increasing antioxidant activity and reducing pro-inflammatory cytokines, such as tumor necrosis factor α and interleukin 1β. Taking together high-dose thymol and carvacrol treatment has an effect close to NAC treatment in APAP toxicity, but thymol has better treatment effect than carvacrol.

scholarly journals Copper Oxide Nanoparticles Impair Serum Biochemical Indices, Induce Histopathological Effects, and Modulate Transcription of Pro-Inflammatory Cytokines, HSP70, and Oxidative Stress Genes in Oreochromis niloticus

2021 ◽  
Author(s):  
Hany M.R. Abdel-Latif ◽  
Mahmoud A.O. Dawood ◽  
Samy F. Mahmoud ◽  
Mustafa Shukry ◽  
Ahmed E. Noreldin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Exposure Period ◽  
Copper Oxide Nanoparticles ◽  
Exposure Dose ◽  
Interleukin 12 ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

In the present study, fish were exposed to sub-lethal doses of CuONPs (68.92 ± 3.49 nm) (10, 20, and 50 mg/L) for a long exposure period (25 days). Compared to the control group (0.0 mg/L CuONPs), a significant dose-dependent elevation in blood urea and creatinine values, serum alanine transaminase, aspartate transaminase, and alkaline phosphatase enzyme activities were evident in CuONPs-exposed groups (P < 0.05). Fish exposure to 50 mg/L CuONPs significantly upregulated the transcription of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin 12, and interleukin 8), heat shock protein 70, apoptosis-related gene (caspase 3), and oxidative stress-related (superoxide dismutase, catalase, and glutathione peroxidase) genes in liver and gills of the exposed fish in comparison with those in the control group (P < 0.05). Moreover, varying histopathological injuries were noticed in the hepatopancreatic tissues, posterior kidneys, and gills of fish groups correlated to the examined exposure dose of CuONPs. In summary, our results provide new insights and helpful information for better understanding the mechanisms of CuONPs toxicity in Nile tilapia at hematological, molecular levels, and tissue levels.

Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress

2015 ◽  
Vol 6 (10) ◽  
pp. 3296-3306 ◽  
Author(s):  
Xiao-Lin Yu ◽  
Ya-Nan Li ◽  
He Zhang ◽  
Ya-Jing Su ◽  
Wei-Wei Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

Rutin inhibited amylin aggregation, amylin-induced neurocytotoxicity, and decreased the production of ROS, NO, GSSG, malondialdehyde and pro-inflammatory cytokines.

scholarly journals The Alteration of Pro-inflammatory Cytokines and Oxidative Stress Markers at Six-Month Post-living Kidney Donation

2020 ◽  
Vol 7 ◽  
Author(s):  
Elodia Nataly Díaz-De la Cruz ◽  
José Ignacio Cerrillos-Gutiérrez ◽  
Andrés García-Sánchez ◽  
Jorge Andrade-Sierra ◽  
Ernesto Germán Cardona-Muñoz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Kidney Donation ◽  
Oxidative Stress Markers ◽  
Living Kidney Donation ◽  
Stress Markers ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines
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