The Prospective Association between Periodontal Disease and Brain Imaging Outcomes: The Atherosclerosis Risk in Communities Study

2021 ◽  
Author(s):  
Hamdi S. Adam ◽  
Kamakshi Lakshminarayan ◽  
Wendy Wang ◽  
Faye L. Norby ◽  
Thomas Mosley ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Brain Imaging ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Prospective Association

Abstract P123: Prospective Association Between Periodontal Disease And Brain Imaging Markers Of Cerebrovascular And Neurodegenerative Disease: The Atherosclerosis Risk In Communities Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Hamdi S Adam ◽  
Kamakshi Lakshminarayan ◽  
Wendy Wang ◽  
Faye L Norby ◽  
Thomas Mosley ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Brain Aging ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Standardized Uptake Value ◽  
Tissue Loss ◽  
Total Brain Volume ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Background: Periodontal disease (PD) is associated positively with neurocognitive outcomes. Few studies have investigated the relationship between PD and indicators of brain aging and vascular changes. Hypothesis: PD is associated with greater cerebral small vessel disease, lower total and regional brain volumes and elevated β-amyloid (Aβ) deposition. Methods: We included 6,793 participants who received full-mouth periodontal examinations and tooth counts at Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities Study. We used a modified 3-level version of the Periodontal Profile Class to categorize PD based on severity and extent of gingival inflammation and tissue loss. Among participants who attended Visit 5 (2011-2013), n=1,306 received a brain MRI and n=248 received a PET scan. Total brain volume, Alzheimer’s disease signature volume, and presence of microhemorrhages and cerebral infarctions were ascertained via 3T MRI; Aβ deposition was assessed from PET. We regressed brain volumes on baseline PD status using weighted multivariable linear regression. Presence of cerebrovascular microhemorrhages, infarctions, or elevated Aβ (standardized uptake value ratio>1.2) were regressed on PD category using logistic models. We examined the interaction between Apolipoprotein E ε4 ( APOE ) allele possession and PD categories on the Aβ outcome. Results: Prevalence of baseline periodontal disease was 73% (959/1306) and 87% (206/248) among the MRI and PET subgroups, respectively. PD was not associated with volumetric brain measures nor microhemorrhages. PD was inversely associated with the odds of subcortical and lacunar infarctions. PD and Aβ were not associated in main effect or interaction analyses, although there was a notably stronger association among carriers of APOE . Conclusion: PD was not associated with altered brain structure, cerebral microhemorrhages or elevated Aβ deposition. Counter to the hypothesis, PD and complete tooth loss were inversely associated with cerebral infarctions.

Abstract MP34: The Association Between Periodontal Disease And Incident Heart Failure: The Atherosclerosis Risk In Communities Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Rebecca L Molinsky ◽  
Faye L Norby ◽  
Bing Yu ◽  
Amil M Shah ◽  
Pamela L Lutsey ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Periodontal Disease ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Atherosclerosis Risk In Communities ◽  
Increased Risk ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure

Introduction: Periodontal disease, resulting from inflammatory host-response to dysbiotic subgingival microbiota, has been associated with incident hypertension, heart attack, stroke and diabetes. Limited data exist investigating the prospective relationship between periodontal disease and incident heart failure (HF) and HF subtypes. We hypothesize that periodontal disease is associated with increased risk for heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). Methods: We studied 6,707 participants enrolled in the Atherosclerosis Risk in Communities Study who received a full-mouth clinical periodontal examination at visit 4 (1996-1998) and had longitudinal follow-up starting in 2005. Participants were classified as being periodontally healthy, having periodontal disease (based on the Periodontal Profile Classification (PPC)), or being edentulous. Hospitalization records were reviewed, and HF events were adjudicated and classified as HFpEF, HFrEF or HF of unknown ejection fraction (HFunknownEF) from 2005-2018. We used multivariable-adjusted Cox proportional hazards models to assess the association between periodontal disease or edentulism and incident HF. Results: Among participants 58% had periodontitis and 19% were edentulous. During a median follow-up time of 13 years, 1,178 cases of incident HF occurred (350 HFpEF, 319 HFrEF and 509 HFunknownEF). Periodontal disease and being edentulous were both associated with increased risk for both HFpEF and HFrEF (Table). Conclusion: Periodontal disease measured in mid-life was associated with both incident HFpEF and HFrEF. Adverse microbial exposures underlying periodontal disease might represent a modifiable risk factor for inflammation-induced heart failure pathophysiology.

scholarly journals Secondhand Smoke and Periodontal Disease: Atherosclerosis Risk in Communities Study

2011 ◽  
Vol 101 (S1) ◽  
pp. S339-S346 ◽  
Author(s):  
Anne E. Sanders ◽  
Gary D. Slade ◽  
James D. Beck ◽  
Helga Ágústsdóttir
Keyword(s):  
Periodontal Disease ◽  
Secondhand Smoke ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

scholarly journals Relationship Between Periodontal Disease and C-Reactive Protein Among Adults in the Atherosclerosis Risk in Communities Study

2003 ◽  
Vol 163 (10) ◽  
pp. 1172 ◽  
Author(s):  
Gary D. Slade ◽  
Elisa M. Ghezzi ◽  
Gerardo Heiss ◽  
James D. Beck ◽  
Estelle Riche ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
C Reactive Protein ◽  
Atherosclerosis Risk In Communities ◽  
Reactive Protein ◽  
Atherosclerosis Risk

scholarly journals Periodontal disease and incident venous thromboembolism: The Atherosclerosis Risk in Communities study

2018 ◽  
Vol 46 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Logan T. Cowan ◽  
Kamakshi Lakshminarayan ◽  
Pamela L. Lutsey ◽  
Aaron R. Folsom ◽  
James Beck ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Periodontal Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk

Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study

2005 ◽  
Vol 45 (4) ◽  
pp. 650-657 ◽  
Author(s):  
Abhijit V. Kshirsagar ◽  
Kevin L. Moss ◽  
John R. Elter ◽  
James D. Beck ◽  
Steve Offenbacher ◽  
...  
Keyword(s):  
Renal Insufficiency ◽  
Periodontal Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Periodontal disease classifications and incident coronary heart disease in the Atherosclerosis Risk in Communities study

2020 ◽  
Vol 91 (11) ◽  
pp. 1409-1418
Author(s):  
James D. Beck ◽  
Kamaira Philips ◽  
Kevin Moss ◽  
Souvik Sen ◽  
Thiago Morelli ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Periodontal Disease ◽  
Incident Coronary Heart Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk
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