Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study

2014 ◽  
Vol 56 (4) ◽  
pp. 460-467 ◽  
Author(s):  
Chang-Ching Wei ◽  
Chun-Hung Chang ◽  
Cheng-Li Lin ◽  
Shih-Ni Chang ◽  
Tsai-Chung Li ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Neonatal Jaundice ◽  
Population Based ◽  
Hyperactivity Disorder ◽  
Increased Risk

Methylphenidate and Mortality in Patients with Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study

2020 ◽  
Author(s):  
Vincent Chin-Hung Chen ◽  
Hsiang-Lin Chan ◽  
Shu-I Wu ◽  
Mong-Liang Lu ◽  
Michael E Dewey ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Hyperactivity Disorder

Risk of Atopic Diseases among Siblings of Patients with Attention-Deficit Hyperactivity Disorder: A Nationwide Population-Based Cohort Study

2019 ◽  
Vol 180 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Tsung-Hsien Chang ◽  
Ying-Hsuan Tai ◽  
Ying-Xiu Dai ◽  
Yun-Ting Chang ◽  
Tzeng-Ji Chen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Atopic Diseases ◽  
Hyperactivity Disorder

Early Life Risk Factors for Attention-Deficit/Hyperactivity Disorder: A Population-Based Cohort Study

2004 ◽  
Vol 79 (9) ◽  
pp. 1124-1131 ◽  
Author(s):  
Jennifer L. St. Sauver ◽  
William J. Barbaresi ◽  
Slavica K. Katusic ◽  
Robert C. Colligan ◽  
Amy L. Weaver ◽  
...  
Keyword(s):  
Risk Factors ◽  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Early Life ◽  
Population Based ◽  
Hyperactivity Disorder

scholarly journals Attention-deficit/hyperactivity disorder and risk for psychiatric and neurodevelopmental disorders in siblings

2018 ◽  
Vol 49 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Elina Jokiranta-Olkoniemi ◽  
Keely Cheslack-Postava ◽  
Petteri Joelsson ◽  
Auli Suominen ◽  
Alan S. Brown ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Neurodevelopmental Disorders ◽  
Neurodevelopmental Disorder ◽  
Population Based ◽  
Autism Spectrum ◽  
Schizophrenia Spectrum Disorders ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
Spectrum Disorders

AbstractBackgroundProbands with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for several psychiatric and neurodevelopmental disorders. The risk of these disorders among the siblings of probands has not been thoroughly assessed in a population-based cohort.MethodsEvery child born in Finland in 1991–2005 and diagnosed with ADHD in 1995–2011 were identified from national registers. Each case was matched with four controls on sex, place, and date of birth. The full siblings of the cases and controls were born in 1981–2007 and diagnosed in 1981–2013. In total, 7369 cases with 12 565 siblings and 23 181 controls with 42 753 siblings were included in the analyses conducted using generalized estimating equations.Results44.2% of the cases and 22.2% of the controls had at least one sibling diagnosed with any psychiatric or neurodevelopmental disorder (risk ratio, RR = 2.1; 95% CI 2.0–2.2). The strongest associations were demonstrated for childhood-onset disorders including ADHD (RR = 5.7; 95% CI 5.1–6.3), conduct and oppositional disorders (RR = 4.0; 95% CI 3.5–4.5), autism spectrum disorders (RR = 3.9; 95% CI 3.3–4.6), other emotional and social interaction disorders (RR = 2.7; 95% CI 2.4–3.1), learning and coordination disorders (RR = 2.6; 95% CI 2.4–2.8), and intellectual disability (RR = 2.4; 95% CI 2.0–2.8). Also, bipolar disorder, unipolar mood disorders, schizophrenia spectrum disorders, other neurotic and personality disorders, substance abuse disorders, and anxiety disorders occurred at increased frequency among the siblings of cases.ConclusionsThe results offer potential utility for early identification of neurodevelopmental and psychiatric disorders in at-risk siblings of ADHD probands and also argue for more studies on common etiologies.

scholarly journals Maternal spontaneous abortion and the risk of attention-deficit/hyperactivity disorder in offspring: a population-based cohort study

2020 ◽  
Vol 35 (5) ◽  
pp. 1211-1221 ◽  
Author(s):  
Hui Wang ◽  
Fei Li ◽  
Maohua Miao ◽  
Yongfu Yu ◽  
Honglei Ji ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Spontaneous Abortion ◽  
Attention Deficit ◽  
Development Program ◽  
Population Based ◽  
Parental History ◽  
Maternal History ◽  
Hyperactivity Disorder ◽  
Increased Risk ◽  
History Of

Abstract STUDY QUESTION Is a maternal history of spontaneous abortion (SA) associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring? SUMMARY ANSWER Our results suggest an association between maternal history of SA and ADHD in offspring, with the risk increasing with the number of maternal SA and highest in the firstborn children whose mothers had had recurrent SAs after adjusting for a number of potential confounders. WHAT IS KNOWN ALREADY A history of SA has been associated with more complications in next pregnancies and adverse childbirth outcomes, which are risk factors for ADHD in the offspring. However, no previous study has investigated whether maternal SA increases risk of ADHD in the offspring. STUDY DESIGN, SIZE, DURATION This population-based study included all live-born children in Denmark from 1 January 1995 to 31 December 2012 (n = 1 062 667). All children were followed from 3 years of age until the day of ADHD diagnosis, death, emigration or 31 December 2016, whichever came first. PARTICIPANTS/MATERIALS, SETTING, METHODS There were 130 206 (12.2%) children born to mothers who had at least one SA. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). MAIN RESULTS AND THE ROLE OF CHANCE During a median follow-up of 9.4 years (interquartile range, 5.4–14.3), 25 747 children were diagnosed with ADHD. Overall, children of mothers with a history of SA had an increased rate of ADHD (HR, 1.11; 95% CI, 1.07 to 1.15). The HRs increased with the number of maternal SA, 1.09 (95% CI, 1.05 to 1.13) for one SA and 1.22 (95% CI, 1.12 to 1.33) for at least two SAs, respectively. These findings were consistent when we took into consideration a number of factors, such as maternal socioeconomic status, type of SA, birth order, parental history of psychiatric disorders, pregnancy characteristics and adverse birth outcomes. LIMITATIONS, REASONS FOR CAUTION Misclassification of SA was possible as we used population-based register data to capture maternal history of SA. However, any misclassification of maternal history of SA would be non-differential with regard to the diagnosis of ADHD in offspring, which generally leads to underestimation of the associations. Furthermore, probabilistic sensitivity analysis suggested that only 1% of change in the estimate may have been due to misclassification of SA. WIDER IMPLICATIONS OF THE FINDINGS SA is quite frequent (varying from 15 to 20%), and a small increase of neurodevelopmental problems in offspring could have major public health implications. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by grants from the National Natural Science Foundation of China (No. 81703237, No. 81530086 and No. 81761128035), National Key Research and Development Program (2018YFC1002801, 2016YFC1000505), Shanghai Municipal Commission of Health and Family Planning (No. 2017ZZ02026, No. 2017EKHWYX-02), the Novo Nordisk Foundation (NNF18OC0052029), the Danish Council for Independent Research (DFF-6110-00019), the Nordic Cancer Union (176673, 186200 and R217-A13234-18-S65), Karen Elise Jensens Fond (2016) and Xinhua Hospital of Shanghai Jiao Tong University School of Medicine (2018YJRC03). All authors report no conflict of interest. TRIAL REGISTRATION NUMBER NA.

scholarly journals Prenatal antibiotic exposure and risk of attention-deficit/hyperactivity disorder: a population-based cohort study

2020 ◽  
Vol 192 (20) ◽  
pp. E527-E535
Author(s):  
Amani F. Hamad ◽  
Silvia Alessi-Severini ◽  
Salaheddin Mahmud ◽  
Marni Brownell ◽  
I fan Kuo
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Antibiotic Exposure ◽  
Hyperactivity Disorder

scholarly journals Drug Treatment Patterns of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents in Germany: Results from a Large Population-Based Cohort Study

2012 ◽  
Vol 22 (6) ◽  
pp. 452-458 ◽  
Author(s):  
Edeltraut Garbe ◽  
Rafael T. Mikolajczyk ◽  
Tobias Banaschewski ◽  
Ulrike Petermann ◽  
Franz Petermann ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Drug Treatment ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Large Population ◽  
Population Based ◽  
Treatment Patterns ◽  
Hyperactivity Disorder

scholarly journals Attention-deficit-hyperactivity disorder increases risk of bone fracture: a population-based cohort study

2014 ◽  
Vol 56 (11) ◽  
pp. 1111-1116 ◽  
Author(s):  
I-Ching Chou ◽  
Che-Chen Lin ◽  
Fung-Chang Sung ◽  
Chia-Hung Kao
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Bone Fracture ◽  
Population Based ◽  
Hyperactivity Disorder

scholarly journals The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 880
Author(s):  
Yair Sadaka ◽  
Judah Freedman ◽  
Shai Ashkenazi ◽  
Shlomo Vinker ◽  
Avivit Golan-Cohen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Early Childhood ◽  
Cohort Study ◽  
Antibiotic Treatment ◽  
Attention Deficit ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hyperactivity Disorder ◽  
Increased Risk

It has recently been shown that children with early shigellosis are at increased risk of attention deficit/hyperactivity disorder (ADHD). This study aimed to evaluate the association between antibiotic treatment of shigellosis with long-term ADHD rates. A retrospective cohort study was conducted that included all the Leumit Health Services (LHS) enrollees aged 5–18 years between 2000–2018 with a documented Shigella-positive gastroenteritis before the age of 3 years. Of the 5176 children who were positive for Shigella gastroenteritis before the age of 3 years, 972 (18.8%) were treated with antibiotics early (<5 days), 250 (4.8%) were treated late (≥5 days), and 3954 children (76.4%) were not prescribed antibiotics. Late antibiotic treatment was associated with significantly increased rates of ADHD (adjusted OR = 1.61; 95% CI, 1.1–2.3). Early treatment with antibiotics was not associated with increased ADHD rates (adjusted OR = 1.02; 95% CI, 0.8–1.3). In conclusion, late antibiotic treatment of early childhood shigellosis was associated with increased rates of ADHD.

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