scholarly journals Prenatal antibiotic exposure and risk of attention-deficit/hyperactivity disorder: a population-based cohort study

2020 ◽  
Vol 192 (20) ◽  
pp. E527-E535
Author(s):  
Amani F. Hamad ◽  
Silvia Alessi-Severini ◽  
Salaheddin Mahmud ◽  
Marni Brownell ◽  
I fan Kuo
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Antibiotic Exposure ◽  
Hyperactivity Disorder

Antibiotic Exposure in the First Year of Life and the Risk of Attention-Deficit/Hyperactivity Disorder: A Population-Based Cohort Study

2019 ◽  
Vol 188 (11) ◽  
pp. 1923-1931 ◽  
Author(s):  
Amani F Hamad ◽  
Silvia Alessi-Severini ◽  
Salaheddin M Mahmud ◽  
Marni Brownell ◽  
I fan Kuo
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Confidence Interval ◽  
Attention Deficit ◽  
Population Based ◽  
First Year ◽  
Antibiotic Exposure ◽  
Matched Cohort ◽  
Hyperactivity Disorder ◽  
First Year Of Life

Abstract Early childhood antibiotic exposure induces changes in gut microbiota reportedly associated with the development of attention-deficit/hyperactivity disorder (ADHD). We conducted a population-based cohort study to examine the association between antibiotic use in the first year of life and ADHD risk. We included children born in Manitoba, Canada, between 1998 and 2017. Exposure was defined as having filled 1 or more antibiotic prescriptions during the first year of life. ADHD diagnosis was identified in hospital abstracts, physician visits, or drug dispensations. Risk of developing ADHD was estimated using Cox proportional hazards regression in a high-dimensional propensity score–matched cohort (n = 69,738) and a sibling cohort (n = 67,671). ADHD risk was not associated with antibiotic exposure in the matched-cohort (hazard ratio = 1.02, 95% confidence interval: 0.97, 1.08) or in the sibling cohort (hazard ratio = 0.96, 95% confidence interval: 0.89, 1.03). In secondary analyses of the matched cohort, ADHD risk increase was observed in those exposed to 4 or more antibiotic courses or a duration longer than 3 weeks. These associations were not observed in the sibling cohort. We concluded that antibiotic exposure in the first year of life does not pose an ADHD risk on a population level.

Methylphenidate and Mortality in Patients with Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study

2020 ◽  
Author(s):  
Vincent Chin-Hung Chen ◽  
Hsiang-Lin Chan ◽  
Shu-I Wu ◽  
Mong-Liang Lu ◽  
Michael E Dewey ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Hyperactivity Disorder

Risk of Atopic Diseases among Siblings of Patients with Attention-Deficit Hyperactivity Disorder: A Nationwide Population-Based Cohort Study

2019 ◽  
Vol 180 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Tsung-Hsien Chang ◽  
Ying-Hsuan Tai ◽  
Ying-Xiu Dai ◽  
Yun-Ting Chang ◽  
Tzeng-Ji Chen ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Population Based ◽  
Atopic Diseases ◽  
Hyperactivity Disorder

Early Life Risk Factors for Attention-Deficit/Hyperactivity Disorder: A Population-Based Cohort Study

2004 ◽  
Vol 79 (9) ◽  
pp. 1124-1131 ◽  
Author(s):  
Jennifer L. St. Sauver ◽  
William J. Barbaresi ◽  
Slavica K. Katusic ◽  
Robert C. Colligan ◽  
Amy L. Weaver ◽  
...  
Keyword(s):  
Risk Factors ◽  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Early Life ◽  
Population Based ◽  
Hyperactivity Disorder

scholarly journals Drug Treatment Patterns of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents in Germany: Results from a Large Population-Based Cohort Study

2012 ◽  
Vol 22 (6) ◽  
pp. 452-458 ◽  
Author(s):  
Edeltraut Garbe ◽  
Rafael T. Mikolajczyk ◽  
Tobias Banaschewski ◽  
Ulrike Petermann ◽  
Franz Petermann ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Drug Treatment ◽  
Children And Adolescents ◽  
Attention Deficit ◽  
Large Population ◽  
Population Based ◽  
Treatment Patterns ◽  
Hyperactivity Disorder

scholarly journals Attention-deficit-hyperactivity disorder increases risk of bone fracture: a population-based cohort study

2014 ◽  
Vol 56 (11) ◽  
pp. 1111-1116 ◽  
Author(s):  
I-Ching Chou ◽  
Che-Chen Lin ◽  
Fung-Chang Sung ◽  
Chia-Hung Kao
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Bone Fracture ◽  
Population Based ◽  
Hyperactivity Disorder

Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study

2014 ◽  
Vol 56 (4) ◽  
pp. 460-467 ◽  
Author(s):  
Chang-Ching Wei ◽  
Chun-Hung Chang ◽  
Cheng-Li Lin ◽  
Shih-Ni Chang ◽  
Tsai-Chung Li ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Attention Deficit ◽  
Neonatal Jaundice ◽  
Population Based ◽  
Hyperactivity Disorder ◽  
Increased Risk

Methylphenidate and mortality in children with attention-deficit hyperactivity disorder: population-based cohort study

2020 ◽  
pp. 1-9
Author(s):  
Vincent Chin-Hung Chen ◽  
Hsiang-Lin Chan ◽  
Shu-I Wu ◽  
Mong-Liang Lu ◽  
Michael E. Dewey ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Health Insurance ◽  
National Health Insurance ◽  
National Health ◽  
Attention Deficit ◽  
Population Based ◽  
Research Database ◽  
Adhd Diagnosis ◽  
Hyperactivity Disorder

Background Little is known about methylphenidate (MPH) use and mortality outcomes. Aims To investigate the association between MPH use and mortality among children with an attention-deficit hyperactivity disorder (ADHD) diagnosis. Method This population-based cohort study analysed data from Taiwan's National Health Insurance Research Database (NHIRD). A total of 68 096 children and adolescents aged 4–17 years with an ADHD diagnosis and prescribed MPH between 2000 and 2010 were compared with 68 096 without an MPH prescription, matched on age, gender and year of first ADHD diagnosis. All participants were followed to death, migration, withdrawal from the National Health Insurance programme or 31 December 2013. MPH prescriptions were measured on a yearly basis during the study period, and the association between MPH use and mortality was analysed using a repeated-measures time-dependent Cox regression model. The outcome measures included all-cause, unnatural-cause (including suicide, accident and homicide) and natural-cause mortality, obtained from linkage to the National Mortality Register in Taiwan. Results The MPH group had lower unadjusted all-cause, natural-, unnatural- and accident-cause mortality than the comparison group. After controlling for potential confounders, MPH use was associated with a significantly lower all-cause mortality (adjusted hazard ratio AHR = 0.81, 95% CI 0.67–0.98, P = 0.027), delayed use of MPH was associated with higher mortality (AHR = 1.05, 95% CI 1.01–1.09) and longer MPH use was associated with lower mortality (AHR = 0.83, 95% CI 0.70–0.98). Conclusions MPH use is associated with a reduced overall mortality in children with ADHD in this cohort study, but unmeasured confounding cannot be excluded absolutely.

Attention-Deficit/Hyperactivity Disorder Treatment and Weight Outcome: A Population-Based Birth Cohort Study

2011 ◽  
pp. P3-695-P3-695
Author(s):  
Roxana L Aguirre ◽  
Slavica K Katusic ◽  
Robert G Voigt ◽  
Cynthia L Leibson ◽  
William J Barbaresi ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cohort Study ◽  
Birth Cohort ◽  
Attention Deficit ◽  
Population Based ◽  
Birth Cohort Study ◽  
Hyperactivity Disorder ◽  
Disorder Treatment
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