Isolation and identification of Lactobacillus plantarum 4F , a strain with high antifungal activity, fungicidal effect, and biopreservation properties of food

2021 ◽  
Author(s):  
Samia El oirdi ◽  
Tarik Lakhlifi ◽  
Ali Adem Bahar ◽  
Meriem Yatim ◽  
Zouhair Rachid ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Lactobacillus Plantarum ◽  
Isolation And Identification ◽  
Fungicidal Effect ◽  
High Antifungal Activity

scholarly journals The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans

2021 ◽  
Author(s):  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Gumieniczek ◽  
Maria Malm ◽  
Krzysztof Z. Łączkowski ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Cell Membrane ◽  
Mode Of Action ◽  
Thiazole Derivatives ◽  
Fungal Cell ◽  
Erythrocyte Lysis ◽  
Low Cytotoxicity ◽  
High Antifungal Activity

Abstract Recently, the occurrence of candidiasis has increased dramatically, especially in immunocompromised patients. Additionally, their treatment is often ineffective due to the resistance of yeasts to antimycotics. Therefore, there is a need to search for new antifungals. A series of nine newly synthesized thiazole derivatives containing the cyclopropane system, showing promising activity against Candida spp., has been further investigated. We decided to verify their antifungal activity towards clinical Candida albicans isolated from the oral cavity of patients with hematological malignancies and investigate the mode of action on fungal cell, the effect of combination with the selected antimycotics, toxicity to erythrocytes, and lipophilicity. These studies were performed by the broth microdilution method, test with sorbitol and ergosterol, checkerboard technique, erythrocyte lysis assay, and reversed phase thin-layer chromatography, respectively. All derivatives showed very strong activity (similar and even higher than nystatin) against all C. albicans isolates with minimal inhibitory concentration (MIC) = 0.008–7.81 µg/mL Their mechanism of action may be related to action within the fungal cell wall structure and/or within the cell membrane. The interactions between the derivatives and the selected antimycotics (nystatin, chlorhexidine, and thymol) showed additive effect only in the case of combination some of them and thymol. The erythrocyte lysis assay confirmed the low cytotoxicity of these compounds as compared to nystatin. The high lipophilicity of the derivatives was related with their high antifungal activity. The present studies confirm that the studied thiazole derivatives containing the cyclopropane system appear to be a very promising group of compounds in treatment of infections caused by C. albicans. However, this requires further studies in vivo. Key points • The newly thiazoles showed high antifungal activity and some of them — additive effect in combination with thymol. • Their mode of action may be related with the influence on the structure of the fungal cell wall and/or the cell membrane. • The low cytotoxicity against erythrocytes and high lipophilicity of these derivatives are their additional good properties. Graphical abstract

N-(5-Amino-9H-benzo[a]phenoxazin-9-ylidene)propan-1-aminium chlorides as antifungal agents and NIR fluorescence probes

2021 ◽  
Author(s):  
Rui P. C. L. Sousa ◽  
João C. C. Ferreira ◽  
Maria João Sousa ◽  
M Sameiro Sameiro T T Gonçalves
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Nile Blue ◽  
Fluorescence Probes ◽  
Cell Labelling ◽  
Nir Fluorescence ◽  
High Antifungal Activity

The search for benzo[a]phenoxazines, Nile Blue derivatives, with high antifungal activity and cell labelling capacity based on our previously published works in this type of compounds, led us to the...

scholarly journals Isolation and identification of bacteriocinogenic strain of Lactobacillus plantarum with potential beneficial properties from donkey milk

2013 ◽  
Vol 114 (6) ◽  
pp. 1793-1809 ◽  
Author(s):  
A. Murua ◽  
S.D. Todorov ◽  
A.D.S. Vieira ◽  
R.C.R. Martinez ◽  
A. Cencič ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Donkey Milk ◽  
Isolation And Identification

scholarly journals Development of Antidandruff Shampoo from the Fermented Product of Ocimum sanctum Linn.

Cosmetics ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. 43 ◽  
Author(s):  
Chanun Punyoyai ◽  
Sasithorn Sirilun ◽  
Panuwan Chantawannakul ◽  
Wantida Chaiyana
Keyword(s):  
Antifungal Activity ◽  
Inhibitory Activity ◽  
Total Soluble Protein ◽  
Diffusion Method ◽  
Ocimum Sanctum ◽  
Level Of Satisfaction ◽  
Fermented Product ◽  
Inhibition Zones ◽  
High Level ◽  
High Antifungal Activity

This study aimed to investigate Malassezia furfur inhibitory activity of the fermented product from Ocimum sanctum and develop an antidandruff shampoo. The fermented product was obtained by the fermentation process of the aerial part of O. sanctum. Total soluble protein was detected in the fermented product with the amount of 65.32 ± 0.14 mg/100 mL, whereas there was no organic acid. The inhibitory activity against four strains of M. furfur (No. 133, 656, 6000, and 7966) of the fermented product and shampoos containing the fermented product were investigated by broth dilution and agar diffusion method, respectively. The fermented product possessed high antifungal activity with the minimum inhibitory concentrations for 50% (MIC50) of M. furfur 133, 656, 6000, and 7966 of 0.125, 0.25, 0.125, and 0.125 mg/mL, respectively. Interestingly, the antifungal activity against M. furfur 656 was comparable to that of ketoconazole. Shampoo formulation C, which was the best formulation in terms of characteristics and stability, obtained a high level of satisfaction scores in terms of hair smoothness, hair shine, ease in combing, frizz reduction, and triboelectric reduction while brushing. Additionally, the shampoo containing 2% (w/w) of the fermented product of O. sanctum also possessed inhibitory activity against M. furfur 133, 656, 6000, and 7966 with inhibition zones of 13.2 ± 1.6, 12.8 ± 1.1, 18.7 ± 0.3, and 17.0 ± 1.1 mm respectively. Therefore, this shampoo was suggested for use as an antidandruff shampoo.

scholarly journals Lactobacillus plantarum with Broad Antifungal Activity as a Protective Starter Culture for Bread Production

Foods ◽  
2017 ◽  
Vol 6 (12) ◽  
pp. 110 ◽  
Author(s):  
Pasquale Russo ◽  
Clara Fares ◽  
Angela Longo ◽  
Giuseppe Spano ◽  
Vittorio Capozzi
Keyword(s):  
Antifungal Activity ◽  
Lactobacillus Plantarum ◽  
Starter Culture ◽  
Bread Production

scholarly journals Mechanochemical synthesis of antifungal bis(benzoxaboroles)

RSC Advances ◽  
2020 ◽  
Vol 10 (61) ◽  
pp. 37187-37193 ◽  
Author(s):  
Krzysztof M. Borys ◽  
Dorota Wieczorek ◽  
Magdalena Tarkowska ◽  
Agnieszka Jankowska ◽  
Jacek Lipok ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Mechanochemical Synthesis ◽  
High Antifungal Activity

Several piperazine bis(benzoxaboroles) have been obtained mechanochemically – two of them have been shown to display high antifungal activity.

Syntheses of Halophenyl-γ-iodopropargyl Ethers Having High Antifungal Activity

1963 ◽  
Vol 27 (2) ◽  
pp. 150-151
Author(s):  
Shigeo Seki ◽  
Ken Nishihata ◽  
Tadayuki Nakayama ◽  
Hiroshi Ogawa
Keyword(s):  
Antifungal Activity ◽  
High Antifungal Activity

scholarly journals Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group

2013 ◽  
Vol 57 (8) ◽  
pp. 3815-3822 ◽  
Author(s):  
Anna N. Tevyashova ◽  
Evgenia N. Olsufyeva ◽  
Svetlana E. Solovieva ◽  
Svetlana S. Printsevskaya ◽  
Marina I. Reznikova ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Cooh Group ◽  
Hydroxyl Groups ◽  
Activity Data ◽  
Oh Groups ◽  
Polyene Antibiotics ◽  
High Antifungal Activity

ABSTRACTA comprehensive comparative analysis of the structure-antifungal activity relationships for the series of biosynthetically engineered nystatin analogues and their novel semisynthetic derivatives, as well as amphotericin B (AMB) and its semisynthetic derivatives, was performed. The data obtained revealed the significant influence of the structure of the C-7 to C-10 polyol region on the antifungal activity of these polyene antibiotics. Comparison of positions of hydroxyl groups in the antibiotics andin vitroantifungal activity data showed that the most active are the compounds in which hydroxyl groups are in positions C-8 and C-9 or positions C-7 and C-10. Antibiotics with OH groups at both C-7 and C-9 had the lowest activity. The replacement of the C-16 carboxyl with methyl group did not significantly affect thein vitroantifungal activity of antibiotics without modifications at the amino group of mycosamine. In contrast, the activity of the N-modified derivatives was modulated both by the presence of CH3or COOH group in the position C-16 and by the structure of the modifying substituent. The most active compounds were testedin vivoto determine the maximum tolerated doses and antifungal activity on the model of candidosis sepsis in leukopenic mice (cyclophosphamide-induced). Study of our library of semisynthetic polyene antibiotics led to the discovery of compounds, namely,N-(l-lysyl)-BSG005 (compound 3n) and, especially,l-glutamate of 2-(N,N-dimethylamino)ethyl amide of S44HP (compound 2j), with high antifungal activity that were comparable inin vitroandin vivotests to AMB and that have better toxicological properties.

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