scholarly journals Development of Antidandruff Shampoo from the Fermented Product of Ocimum sanctum Linn.

Cosmetics ◽  
2018 ◽  
Vol 5 (3) ◽  
pp. 43 ◽  
Author(s):  
Chanun Punyoyai ◽  
Sasithorn Sirilun ◽  
Panuwan Chantawannakul ◽  
Wantida Chaiyana
Keyword(s):  
Antifungal Activity ◽  
Inhibitory Activity ◽  
Total Soluble Protein ◽  
Diffusion Method ◽  
Ocimum Sanctum ◽  
Level Of Satisfaction ◽  
Fermented Product ◽  
Inhibition Zones ◽  
High Level ◽  
High Antifungal Activity

This study aimed to investigate Malassezia furfur inhibitory activity of the fermented product from Ocimum sanctum and develop an antidandruff shampoo. The fermented product was obtained by the fermentation process of the aerial part of O. sanctum. Total soluble protein was detected in the fermented product with the amount of 65.32 ± 0.14 mg/100 mL, whereas there was no organic acid. The inhibitory activity against four strains of M. furfur (No. 133, 656, 6000, and 7966) of the fermented product and shampoos containing the fermented product were investigated by broth dilution and agar diffusion method, respectively. The fermented product possessed high antifungal activity with the minimum inhibitory concentrations for 50% (MIC50) of M. furfur 133, 656, 6000, and 7966 of 0.125, 0.25, 0.125, and 0.125 mg/mL, respectively. Interestingly, the antifungal activity against M. furfur 656 was comparable to that of ketoconazole. Shampoo formulation C, which was the best formulation in terms of characteristics and stability, obtained a high level of satisfaction scores in terms of hair smoothness, hair shine, ease in combing, frizz reduction, and triboelectric reduction while brushing. Additionally, the shampoo containing 2% (w/w) of the fermented product of O. sanctum also possessed inhibitory activity against M. furfur 133, 656, 6000, and 7966 with inhibition zones of 13.2 ± 1.6, 12.8 ± 1.1, 18.7 ± 0.3, and 17.0 ± 1.1 mm respectively. Therefore, this shampoo was suggested for use as an antidandruff shampoo.

scholarly journals IN-VITROSTUDIES ON ANTIFUNGALACTIVITY OF SOMEMISTLETOE SPECIES

2021 ◽  
Vol 9 (06) ◽  
pp. 420-427
Author(s):  
R. Neelima ◽  
◽  
B. Sujatha ◽  
N.V. Ramana ◽  
B.V. Rao ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetate ◽  
Phytophthora Infestans ◽  
Inhibitory Activity ◽  
Sclerotium Rolfsii ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Leaf Extracts

In vitro evaluation of antifungal activity by disc diffusion method was carried out on leaf extracts of D.falcata, D. falcata var pubescens, V. monoicum and V. orientale and stem extracts of D. falcata, D. falcata var pubescens, V. articulatum and V.orientale using three different solvents viz., methanol, n-hexane and ethyl acetate. The antifungal activity was tested on three fungal strains include Fusarium oxysporum, Phytophthora infestans, Sclerotium rolfsii. Overall leaf extracts exerted better inhibitory activity than stem counterparts. Among all, only V. orientale was effective against the three fungal species.Compared to stem extracts, leaf extracts of D. falcata var pubescens have shown higher antifungal activity.

scholarly journals Chemical investigation, the antibacterial and antifungal activity of different parts of Capparis spinosa extracts

2020 ◽  
Vol 10 (5) ◽  
pp. 118-125
Author(s):  
Nadia Benzidane ◽  
Ridha Aichour ◽  
Sofiane Guettaf ◽  
Noureddine Laadel ◽  
Seddik Khennouf ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Inhibitory Activity ◽  
Pharmacological Effect ◽  
The Other ◽  
Chemical Investigation ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
North East ◽  
Capparis Spinosa ◽  
Different Parts

Capparis spinosa (Capparidacea), is one of the most used medicinal plants worldwide. It is used for the treatment of various diseases because of its biological and pharmacological effect, such as antioxidant, anticancer, antihypertensive, antidiabetic and antibacterial. Phytochemical analysis of the plant showed that it is a rich source of bioactive constituents, including alkaloids, glucosinolates, tocopherols, carotenoids and polyphenols, which have led to C. spinosa being considered as a promising medicinal plant. Our study aims to detail the chemical profiles of the present bioactive responsible for the pharmacological effects of C. spinosa; it also aims to experimentally demonstrate the presence of polyphenols in different parts of the plant as well as their antimicrobial effects. For this, we used methanolic and aqueous extracts of the different parts of the plant picked in Beni Aziz in the Sétif region (North-east of Algeria). The extracts subjected to TLC and HPLC showed that they were rich in flavonoids and phenolic acids. This led to find that rutin was the most dominant compound in most of our extracts. On the other hand, the antimicrobial effect was tested by the disk diffusion method on three bacterial strains: E. coli, P. aeruginosa and S. aureus and two fungi: C. albicans and A. flavus. Candida albicans’s antifungal effect of our extracts was absent. While the same extracts showed a slight inhibitory activity against Aspergillus flavus. As for the antibacterial effect, it exists only for the methanolic extract of the twigs against Staphylococcus aureus. While the other extracts only showed a slight inhibitory activity against the same strain. The other strains of bacteria were resistant to all extracts at any used concentration. Keywords: Capparis spinosa, Pharmacological effect, Chemical investigation, antibacterial activity, phenolic compounds, antifungal activity.                                                                                                                                                                                         

Synthesis and Characterization of Some New 1,3,4-thiadiazole Compounds Derived from 3,4-(Methylenedioxy)cinnamic Acid and their Antimicrobial Activities

2019 ◽  
Vol 16 (10) ◽  
pp. 825-836
Author(s):  
Halit Muğlu ◽  
Mahmut Gür ◽  
Maesm Ahmed Mohamed Ben Hsin ◽  
Nesrin Şener ◽  
Sevil Özkınalı ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Cinnamic Acid ◽  
Salmonella Enteritidis ◽  
Inhibition Zone ◽  
Disk Diffusion ◽  
Diffusion Method ◽  
Compound Viii ◽  
Disk Diffusion Method ◽  
Inhibition Zones

Some new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR, 1H-NMR, and 13C-NMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella infantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones using 50 and 80 µL. One compound (IX) showed antibacterial activity against E. aerogenes, exhibiting a 12 mm inhibition zone using 80 µL. One compound (XIII) showed antibacterial activity against S. kentucky, exhibiting an inhibition zone of about 9 mm using 80 µL. Also, one compound (VII) showed antibacterial activity against E. durans, exhibiting 7, 7, and 8 mm inhibition zones using 30, 50, and 80 µL. None of the compounds (I-XV) showed antifungal activity against C. albicans. These results showed that some of the synthesized compounds could be used as antibacterial agents.

Therapeutic efficacy of some extracts of hot pepper fruits (Capsicum annuum) and Sumac seeds (Rhus coriaria) on the growth of some isolated dermatophytes species

2018 ◽  
Vol 1 (3) ◽  
pp. 52-62
Author(s):  
Sara Omran ◽  
Abdulghani Alsamarai ◽  
Firas Razzzaq
Keyword(s):  
Antifungal Activity ◽  
Fungal Infection ◽  
Aqueous Extract ◽  
Plant Extracts ◽  
Therapeutic Efficacy ◽  
Diffusion Method ◽  
Quantitative Detection ◽  
Hot Pepper ◽  
Alcoholic Extract ◽  
Dermatology Clinic

Background: Fungal infections are one of the common skin diseases with difficulty in their treatment approach. The present efficient drugs for fungal infection are limited. Aim: To determine the therapeutic efficacy of plant extracts as alternative antifungal agents. Materials and methods: 100 clinical samples [68 from female and 32 from male] were collected during the period from March to July 2017 from subjects attending Dermatology Clinic in Salah Uldean General Hospital. Fungal infection was diagnosed with using KOH wet preparation. Fungal species identified by using conventional approach. The active ingredients existing in the plant extracts were detected and analyzed through qualitative and quantitative detection technique of chemical compounds using a high performance liquid chromatographic device (HPLC). Agar diffusion method was used to determine antifungal activity of plant extracts. Results: Direct microscopic examination showed that there were (75%) positive samples, while culture shows (67%) positive samples. The isolated dermatophytes belong to Epidermophyoton, Microsporum, and Trichophyton genus. The predominant dermatophytes were T. rubrum (25%) species. The highest frequency of infection was in the age group of 11-20 years. The sensitivity of the tested fungi to the aqueous and alcoholic plant extracts varies. Alcoholic extract of the hot pepper plant was more effective as antifungal than the aqueous extract of the same plant. However, aqueous hot pepper extracts was more effective against T. mentagrophyte than that of alcoholic extract. Additionally, alcoholic Sumac extract shows higher efficacy that aqueous extract. Conclusion: Hot pepper and Sumac extracts show antifungal activity against Microsporum canis, Trichophyton rubrum and T. mentagrophyte.

Decision making power of college girls in relation to clothing

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Parul Gill ◽  
Poonam Malik ◽  
Pankaj Gill
Keyword(s):  
Decision Making ◽  
Satisfaction Level ◽  
College Going ◽  
Level Of Satisfaction ◽  
High Level ◽  
Garment Design ◽  
Structured Questionnaire

The present study was undertaken to explore the decision making patterns of college girls in relation to clothing and their satisfaction level with these decision making patterns. Thirty under graduate college girls from Panipat city were approached to record their responses regarding decision making in relation to clothing and satisfaction level through a well structured questionnaire. It was found that most of the girls (56.66%) themselves made the decisions about the type of garment (Indian, western or both) they wear and majority of girls (70%) were highly satisfied with this decision making. Parents performed the role of buyers for their college going daughters' garments in most of the cases (63.33%) and the 73.33% girls had high level of satisfaction with this. In most of the cases (60%) the decision about the garment design was made by the girls themselves and they were highly satisfied with it. Keywords: clothing, college, girls, decision making.

PENGARUH CITRA PERUSAHAAN DAN KEPERCAYAAN TERHADAP KEPUASAN PASIEN PADA RUMAH SAKIT MITRA MEDIKA NAROM KABUPATEN BEKASI

2020 ◽  
Vol 7 (1) ◽  
pp. 41-49
Author(s):  
Ajat Sudrajat
Keyword(s):  
Patient Satisfaction ◽  
Health Services ◽  
Corporate Image ◽  
Ordinal Scale ◽  
Survey Method ◽  
Microsoft Excel ◽  
Analysis Techniques ◽  
Level Of Satisfaction ◽  
Verification Methods ◽  
High Level

Patient satisfaction at the hospital is a benchmark that is a benchmark for patients in getting health care. Each hospital must run a variety of strategies so that patients feel satisfied with health services, one of the strategies is through a good corporate image and trust, where a good corporate image can increase trust. So that affecting patient satisfaction Mitra Medika Narom Hospital Kabupaten Bekasi.             This research was conducted with descriptive and verification methods, namely knowing, analyzing, explaining and testing hypotheses, and making conclusions and suggestions. The sample in this study amounted to 240 respondents using the Eksplanary Survey method. Data analysis techniques used are ordinal scale techniques and path analysis using the Method of Successive Interval (MSI) tool, Microsoft Excel 2016 computer programs and SPSS 16.             The results of this study reveal that the company's image at the Mitra Medika Narom Hospital in Kabupaten Bekasi is in the agreed criteria, meaning that Mitra Medika Narom Hospital has built and made a good company image so that it is better known to all people. Furthermore, trust in Mitra Medika Narom Hospital in Kabupaten Bekasi is in the agreed criteria, meaning that Mitra Medika Narom Hospital has succeeded in building a good and optimal Trust so that patients trust Mitra Medika Narom Hospital to obtain health services. Then the patient satisfaction at the Mitra Medika Narom Hospital in Kabupaten Bekasi is in the agreed criteria, meaning that the patients as respondents feel a high level of satisfaction after completing treatment at the Mitra Medika Narom Hospital. There is a positive, strong and two-way correlation between company image and trust variables of 0.646. There is a partial influence of company image on patient satisfaction at Mitra Medika Narom Hospital significantly by 11.98%. There is a partial influence of trust on patient satisfaction at Mitra Medika Narom Hospital significantly by 25.08%. Then there is a simultan influence of corporate image and trust on patient satisfaction at Mitra Medika Narom Hospital positively and significantly by 37.06% while the remaining 62.94% is contributed by other variables not examined

scholarly journals The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans

2021 ◽  
Author(s):  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Gumieniczek ◽  
Maria Malm ◽  
Krzysztof Z. Łączkowski ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Cell Membrane ◽  
Mode Of Action ◽  
Thiazole Derivatives ◽  
Fungal Cell ◽  
Erythrocyte Lysis ◽  
Low Cytotoxicity ◽  
High Antifungal Activity

Abstract Recently, the occurrence of candidiasis has increased dramatically, especially in immunocompromised patients. Additionally, their treatment is often ineffective due to the resistance of yeasts to antimycotics. Therefore, there is a need to search for new antifungals. A series of nine newly synthesized thiazole derivatives containing the cyclopropane system, showing promising activity against Candida spp., has been further investigated. We decided to verify their antifungal activity towards clinical Candida albicans isolated from the oral cavity of patients with hematological malignancies and investigate the mode of action on fungal cell, the effect of combination with the selected antimycotics, toxicity to erythrocytes, and lipophilicity. These studies were performed by the broth microdilution method, test with sorbitol and ergosterol, checkerboard technique, erythrocyte lysis assay, and reversed phase thin-layer chromatography, respectively. All derivatives showed very strong activity (similar and even higher than nystatin) against all C. albicans isolates with minimal inhibitory concentration (MIC) = 0.008–7.81 µg/mL Their mechanism of action may be related to action within the fungal cell wall structure and/or within the cell membrane. The interactions between the derivatives and the selected antimycotics (nystatin, chlorhexidine, and thymol) showed additive effect only in the case of combination some of them and thymol. The erythrocyte lysis assay confirmed the low cytotoxicity of these compounds as compared to nystatin. The high lipophilicity of the derivatives was related with their high antifungal activity. The present studies confirm that the studied thiazole derivatives containing the cyclopropane system appear to be a very promising group of compounds in treatment of infections caused by C. albicans. However, this requires further studies in vivo. Key points • The newly thiazoles showed high antifungal activity and some of them — additive effect in combination with thymol. • Their mode of action may be related with the influence on the structure of the fungal cell wall and/or the cell membrane. • The low cytotoxicity against erythrocytes and high lipophilicity of these derivatives are their additional good properties. Graphical abstract

N-(5-Amino-9H-benzo[a]phenoxazin-9-ylidene)propan-1-aminium chlorides as antifungal agents and NIR fluorescence probes

2021 ◽  
Author(s):  
Rui P. C. L. Sousa ◽  
João C. C. Ferreira ◽  
Maria João Sousa ◽  
M Sameiro Sameiro T T Gonçalves
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Nile Blue ◽  
Fluorescence Probes ◽  
Cell Labelling ◽  
Nir Fluorescence ◽  
High Antifungal Activity

The search for benzo[a]phenoxazines, Nile Blue derivatives, with high antifungal activity and cell labelling capacity based on our previously published works in this type of compounds, led us to the...

scholarly journals Does Gamifying Homework Influence Performance and Perceived Gameful Experience?

2021 ◽  
Vol 13 (9) ◽  
pp. 4829
Author(s):  
Ahmed Hosny Saleh Metwally ◽  
Maiga Chang ◽  
Yining Wang ◽  
Ahmed Mohamed Fahmy Yousef
Keyword(s):  
Learning Analytics ◽  
Educational Settings ◽  
Control Groups ◽  
Level Of Satisfaction ◽  
Growing Body ◽  
High Level ◽  
And Control

There is a growing body of literature that recognizes the importance of applying gamification in educational settings. This research developed an application to gamify students’ homework to address the concern of the students’ inability to complete their homework. This research aims to investigate students’ performance in doing their homework, and reflections and perceptions of the gameful experience in gamified homework exercises. Based on the data gathered from experimental and control groups (N = 84) via learning analytics, survey, and interview, the results show a high level of satisfaction according to students’ feedback. The most noticeable finding to extract from the analysis is that students can take on a persona, earn points, and experience a deeper sense of achievement through doing the gamified homework. Moreover, the students, on the whole, are likely to be intrinsically motivated whenever the homework is attributed to factors under their own control, when they consider that they have the expertise to be successful learners to achieve their desired objectives, and when they are interested in dealing with the homework for learning, not just achieving high grades.

scholarly journals An In Vitro Study on the Antimicrobial Properties of Essential Oil Modified Resin Composite against Oral Pathogens

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4383
Author(s):  
Barbara Lapinska ◽  
Aleksandra Szram ◽  
Beata Zarzycka ◽  
Janina Grzegorczyk ◽  
Louis Hardan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Resin Composite ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Diffusion Method ◽  
Oral Pathogens

Modifying the composition of dental restorative materials with antimicrobial agents might induce their antibacterial potential against cariogenic bacteria, e.g., S.mutans and L.acidophilus, as well as antifungal effect on C.albicans that are major oral pathogens. Essential oils (EOs) are widely known for antimicrobial activity and are successfully used in dental industry. The study aimed at evaluating antibacterial and antifungal activity of EOs and composite resin material (CR) modified with EO against oral pathogens. Ten EOs (i.e., anise, cinnamon, citronella, clove, geranium, lavender, limette, mint, rosemary thyme) were tested using agar diffusion method. Cinnamon and thyme EOs showed significantly highest antibacterial activity against S.mutans and L.acidophilus among all tested EOs. Anise and limette EOs showed no antibacterial activity against S.mutans. All tested EOs exhibited antifungal activity against C.albicans, whereas cinnamon EO showed significantly highest and limette EO significantly lowest activity. Next, 1, 2 or 5 µL of cinnamon EO was introduced into 2 g of CR and microbiologically tested. The modified CR showed higher antimicrobial activity in comparison to unmodified one. CR containing 2 µL of EO showed the best antimicrobial properties against S.mutans and C.albicans, while CR modified with 1 µL of EO showed the best antimicrobial properties against L.acidophilus.

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