Takotsubo Cardiomyopathy in an Elderly Woman with Alzheimer's Disease: A Rare Association. Case Report and Mini-Review of the Literature

Context: The Takotsubo cardiomyopathy (TTC) is an acute cardiac dysfunction, clinically similar to myocardial ischemia, more common in postmenopausal women and related to emotional stress. Case report: A 71-year-old female patient, with Alzheimer’s disease (AD), sought emergency care after severe chest pain. Electrocardiogram showed ST segment elevation in the anteroseptal wall. Physical exam: HR=108bpm, PA=126x78mmHg, SaO2=6%. Complementary exams showed a mild lesion in the middle third of the anterior descending artery, moderate impairment of left ventricular (LV) function by apical aneurysm without thrombi, mitral prolapse with mild reflux and an ejection fraction of 37%, suspecting of TTC. Conclusions: TTC is defined as a transient, usually reversible and segmental LV dysfunction, configuring a differential diagnosis of acute coronary syndrome. An overactivation of the sympathetic autonomic nervous system can cause catecholamine toxicity to the heart. Although several studies show a lower emotional response capacity in patients with cognitive impairment, more recent studies suggest that this emotional responsiveness is not so affected by dementia. Therefore, patients with AD may be susceptible to developing TTC, both because of the multiple drugs that they are exposed, increasing catecholamine levels, and because of the disease itself, that represents a stressful context. Thus, TTC is often associated with emotional stress and should not be overlooked in patients with AD.

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Familial Alzheimer’s Disease due to Presenilin 1 Mutation at the Age of 33: a Case Report

SN Comprehensive Clinical Medicine ◽

10.1007/s42399-021-00982-5 ◽

2021 ◽

Author(s):

Rita Raimundo ◽

Rafael Jesus ◽

Andreia Veiga

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Case Report ◽

Presenilin 1 ◽

Familial Alzheimer’S Disease ◽

Presenilin 1 Mutation ◽

Familial Alzheimer's Disease

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A Case Report of a 37-Year-Old Alzheimer's Disease Patient with Prominent Striatum Amyloid Retention

Psychiatry Investigation ◽

10.4306/pi.2017.14.4.521 ◽

2017 ◽

Vol 14 (4) ◽

pp. 521 ◽

Cited By ~ 5

Author(s):

Yoo Hyun Um ◽

Woo Hee Choi ◽

Won Sang Jung ◽

Young Ha Park ◽

Chang-Uk Lee ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Case Report ◽

Disease Patient

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Successful Combination Therapy of Trazodone and Fluvoxamine for Pica in Alzheimer's Disease: A Case Report

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.704847 ◽

2021 ◽

Vol 12 ◽

Author(s):

Tadashi Kanamori ◽

Yoshiyuki Kaneko ◽

Kouju Yamada ◽

Masahiro Suzuki

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Case Report ◽

Drug Therapy ◽

Combination Therapy ◽

Frontotemporal Dementia ◽

Late Stage ◽

Daytime Sleepiness ◽

Extrapyramidal Symptoms ◽

Common Drug

Pica in Alzheimer's disease (AD) makes it difficult for caregivers to provide care. However, few effective medications have been reported for pica in AD. We report a case of AD with pica that was successfully improved by trazodone and fluvoxamine. An 80-year-old woman with AD was admitted to our hospital due to aggravated pica, including eating weeds in the facility's garden and eating a dishwashing sponge. Her pica was accompanied by oral tendency, prosopagnosia, and placidity. She took rivastigmine and memantine, but these were ineffective for her pica. She was given olanzapine and perospirone, but both were discontinued due to over-sedation and severe extrapyramidal symptoms, respectively. We then administered trazodone and fluvoxamine, both of which have demonstrated effectiveness for pica in frontotemporal dementia (FTD). Her pica behaviors then disappeared without daytime sleepiness. In this case, pica with oral tendency, which was accompanied by prosopagnosia and placidity, may be interpreted as a partial symptom of Klüver–Bucy syndrome (KBS). KBS is often seen in FTD, but also occurs in late-stage AD. Our case together with previous reports showing that trazodone and fluvoxamine were effective for pica in FTD suggest that the same common drug therapy may be successful in pica with oral tendency, regardless of the subtype of dementia.

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Late Onset Alzheimer Dementia in Patients with Genotype E3/E4: A Case Report

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5583 ◽

2021 ◽

Vol 9 (C) ◽

pp. 5-9

Author(s):

Anak Agung Ayu Putri Laksmidewi ◽

Chiquita Putri Vania Rau

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Case Report ◽

Mini Mental State Examination ◽

Late Onset ◽

Apoe Genotype ◽

Time Orientation ◽

Alzheimer Dementia ◽

The Family ◽

State Examination

BACKGROUND: Dementia is one of the leading causes of disability and dependence in elderly worldwide. Epidemiological statistics indicate that data show that at about 60–80%, Alzheimer’s is the most common type of dementia. Alzheimer’s is also the third-most prominent cause of death in elderly. CASE REPORT: A 72-years-old male patient, complained by the family often forgets about things that have just been done for 3 years ago. According to the family, patient also often discussing the same things repeatedly. Patients tend not to have the initiative to start his daily activities. The family admitted that patient also became often angry and felt suspicious for the last 2 years. From the mini mental state examination showed disturbances in time orientation and recall; from Montreal Cognitive Assessment Ina found disturbances in visuospatial, fluency, abstraction, delayed memory, and time orientation; accompanied by activities of daily living (ADL) and instrumental ADL disorders. Patient also performed a molecular examination of the apolipoprotein E (APOE) genotype and the genotype E3/E4 was detected. CONCLUSION: The function of the APOE gene, in particular APOE4, is the most emphasized genetic relationship in late onset Alzheimer’s disease. It is proposed that blocking the action of APOE4 can delay or stop Alzheimer’s disease progression.

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Adult Laryngeal Rhabdomyosarcoma: is aggressive treatment justified in all cases? A case report and review of the literature

The Journal of Laryngology & Otology ◽

10.1017/s0022215109990946 ◽

2009 ◽

Vol 123 (11) ◽

Cited By ~ 3

Author(s):

G X Papacharalampous ◽

L Manolopoulos ◽

S Korres ◽

C Dicoglou ◽

A Bibas

Keyword(s):

Case Report ◽

Endoscopic Resection ◽

Surgical Procedures ◽

Total Laryngectomy ◽

Elderly Woman ◽

Aggressive Treatment ◽

Combination Therapies ◽

Review Of The Literature ◽

Biological Behaviour ◽

Rare Tumours

AbstractBackground:Adult laryngeal rhabdomyosarcomas are rare tumours commonly treated by laryngectomy.Case report:We present a case of subglottic laryngeal rhabdomyosarcoma in an elderly woman, treated by endoscopic resection.Conclusion:Despite the fact that this tumour is traditionally treated aggressively, this approach is not supported by the literature. Due to the varying biological behaviour of this tumour in adults, we believe that conservative surgical procedures or combination therapies should be preferred, rather than total laryngectomy.

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