scholarly journals Altered glucose catabolism in the presynaptic and perisynaptic compartments of SOD1G93Amouse spinal cord and motor cortex indicates that mitochondria are the site of bioenergetic imbalance in ALS

2019 ◽  
Vol 151 (3) ◽  
pp. 336-350 ◽  
Author(s):  
Silvia Ravera ◽  
Carola Torazza ◽  
Tiziana Bonifacino ◽  
Francesca Provenzano ◽  
Claudia Rebosio ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Glucose Catabolism ◽  
Altered Glucose

scholarly journals Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 143
Author(s):  
Ganchimeg Davaa ◽  
Jin Young Hong ◽  
Tae Uk Kim ◽  
Seong Jae Lee ◽  
Seo Young Kim ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Cortex ◽  
Functional Recovery ◽  
Treadmill Exercise ◽  
Exercise Group ◽  
Control Group ◽  
Epigenetic Changes ◽  
Cord Injury ◽  
The Brain

Exercise training is a traditional method to maximize remaining function in patients with spinal cord injury (SCI), but the exact mechanism by which exercise promotes recovery after SCI has not been identified; whether exercise truly has a beneficial effect on SCI also remains unclear. Previously, we showed that epigenetic changes in the brain motor cortex occur after SCI and that a treatment leading to epigenetic modulation effectively promotes functional recovery after SCI. We aimed to determine how exercise induces functional improvement in rats subjected to SCI and whether epigenetic changes are engaged in the effects of exercise. A spinal cord contusion model was established in rats, which were then subjected to treadmill exercise for 12 weeks. We found that the size of the lesion cavity and the number of macrophages were decreased more in the exercise group than in the control group after 12 weeks of injury. Immunofluorescence and DNA dot blot analysis revealed that levels of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in the brain motor cortex were increased after exercise. Accordingly, the expression of ten-eleven translocation (Tet) family members (Tet1, Tet2, and Tet3) in the brain motor cortex also elevated. However, no macrophage polarization was induced by exercise. Locomotor function, including Basso, Beattie, and Bresnahan (BBB) and ladder scores, also improved in the exercise group compared to the control group. We concluded that treadmill exercise facilitates functional recovery in rats with SCI, and mechanistically epigenetic changes in the brain motor cortex may contribute to exercise-induced improvements.

scholarly journals Combined motor cortex and spinal cord neuromodulation promotes corticospinal system functional and structural plasticity and motor function after injury

2016 ◽  
Vol 277 ◽  
pp. 46-57 ◽  
Author(s):  
Weiguo Song ◽  
Alzahraa Amer ◽  
Daniel Ryan ◽  
John H. Martin
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Motor Function ◽  
Structural Plasticity ◽  
Corticospinal System

The effect of transcranial magnetic stimulation on the excitability of the motor neuron pools of the muscles of the lower extremities

2021 ◽  
Author(s):  
S.S. Ananiev ◽  
D.A. Pavlov ◽  
R.N. Yakupov ◽  
V.A. Golodnova ◽  
M.V. Balykin
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Transcranial Magnetic Stimulation ◽  
Motor Cortex ◽  
Magnetic Stimulation ◽  
Primary Motor Cortex ◽  
Lower Extremities ◽  
Transcutaneous Electrical Stimulation ◽  
Stimulation Of

The study was conducted on 22 healthy men aged 18-23 years. The primary motor cortex innervating the lower limb was stimulated with transcranial magnetic stimulation. Using transcutaneous electrical stimulation of the spinal cord, evoked motor responses of the muscles of the lower extremities were initiated when electrodes were applied cutaneous between the spinous processes in the Th11-Th12 projection. Research protocol: Determination of the thresholds of BMO of the muscles of the lower extremities during TESCS; determination of the BMO threshold of the TA muscle in TMS; determination of the thresholds of the BMO of the muscles of the lower extremities during TESCS against the background of 80% and 90% TMS. It was found that magnetic stimulation of the motor cortex of the brain leads to an increase in the excitability of the neural structures of the lumbar thickening of the spinal cord and an improvement in neuromuscular interactions. Key words: transcranial magnetic stimulation, transcutaneous electrical stimulation of the spinal cord, neural networks, excitability, neuromuscular interactions.

scholarly journals Do neurons from the primary motor cortex grow in response to signals from the developing spinal cord in vitro?

2015 ◽  
Author(s):  
F Alhumaid ◽  
S Almutairi ◽  
P Roach ◽  
HR Fuller ◽  
MA Gates
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Developing Spinal Cord

The effect of continuous theta burst stimulation over premotor cortex on circuits in primary motor cortex and spinal cord

2009 ◽  
Vol 120 (4) ◽  
pp. 796-801 ◽  
Author(s):  
Ying-Zu Huang ◽  
John C. Rothwell ◽  
Chin-Song Lu ◽  
JiunJie Wang ◽  
Yi-Hsin Weng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

Spinal cord representation of motor cortex plasticity reflects corticospinal tract LTP

2021 ◽  
Vol 118 (52) ◽  
pp. e2113192118
Author(s):  
Alzahraa Amer ◽  
Jianxun Xia ◽  
Michael Smith ◽  
John H. Martin
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Corticospinal Tract ◽  
Cervical Spinal Cord ◽  
Long Term Potentiation ◽  
Dependent Manner ◽  
Term Potentiation ◽  
Spinal Cord Segment ◽  
Spinal Interneuron ◽  
Activity Dependent

Although it is well known that activity-dependent motor cortex (MCX) plasticity produces long-term potentiation (LTP) of local cortical circuits, leading to enhanced muscle function, the effects on the corticospinal projection to spinal neurons has not yet been thoroughly studied. Here, we investigate a spinal locus for corticospinal tract (CST) plasticity in anesthetized rats using multichannel recording of motor-evoked, intraspinal local field potentials (LFPs) at the sixth cervical spinal cord segment. We produced LTP by intermittent theta burst electrical stimulation (iTBS) of the wrist area of MCX. Approximately 3 min of MCX iTBS potentiated the monosynaptic excitatory LFP recorded within the CST termination field in the dorsal horn and intermediate zone for at least 15 min after stimulation. Ventrolaterally, in the spinal cord gray matter, which is outside the CST termination field in rats, iTBS potentiated an oligosynaptic negative LFP that was localized to the wrist muscle motor pool. Spinal LTP remained robust, despite pharmacological blockade of iTBS-induced LTP within MCX using MK801, showing that activity-dependent spinal plasticity can be induced without concurrent MCX LTP. Pyramidal tract iTBS, which preferentially activates the CST, also produced significant spinal LTP, indicating the capacity for plasticity at the CST–spinal interneuron synapse. Our findings show CST monosynaptic LTP in spinal interneurons and demonstrate that spinal premotor circuits are capable of further modifying descending MCX control signals in an activity-dependent manner.

scholarly journals Spinogenesis in spinal cord motor neurons following pharmacological lesions to the rat motor cortex

2019 ◽  
Author(s):  
N.I. Martínez-Torres ◽  
D. González-Tapia ◽  
M. Flores-Soto ◽  
N. Vázquez-Hernández ◽  
H. Salgado-Ceballos ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Motor Neurons

scholarly journals Different phase delays of peripheral input to primate motor cortex and spinal cord promote cancellation at physiological tremor frequencies

2014 ◽  
Vol 111 (10) ◽  
pp. 2001-2016 ◽  
Author(s):  
Saša Koželj ◽  
Stuart N. Baker
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Motor Behavior ◽  
Cervical Spinal Cord ◽  
Late Response ◽  
Physiological Tremor ◽  
Phase Cancellation ◽  
Overall Stability ◽  
Response Onset ◽  
Frequency Relationship

Neurons in the spinal cord and motor cortex (M1) are partially phase-locked to cycles of physiological tremor, but with opposite phases. Convergence of spinal and cortical activity onto motoneurons may thus produce phase cancellation and a reduction in tremor amplitude. The mechanisms underlying this phase difference are unknown. We investigated coherence between spinal and M1 activity with sensory input. In two anesthetized monkeys, we electrically stimulated the medial, ulnar, deep radial, and superficial radial nerves; stimuli were timed as independent Poisson processes (rate 10 Hz). Single units were recorded from M1 (147 cells) or cervical spinal cord (61 cells). Ninety M1 cells were antidromically identified as pyramidal tract neurons (PTNs); M1 neurons were additionally classified according to M1 subdivision (rostral/caudal, M1r/c). Spike-stimulus coherence analysis revealed significant coupling over a broad range of frequencies, with the strongest coherence at <50 Hz. Delays implied by the slope of the coherence phase-frequency relationship were greater than the response onset latency, reflecting the importance of late response components for the transmission of oscillatory inputs. The spike-stimulus coherence phase over the 6–13 Hz physiological tremor band differed significantly between M1 and spinal cells (phase differences relative to the cord of 2.72 ± 0.29 and 1.72 ± 0.37 radians for PTNs from M1c and M1r, respectively). We conclude that different phases of the response to peripheral input could partially underlie antiphase M1 and spinal cord activity during motor behavior. The coordinated action of spinal and cortical feedback will act to reduce tremulous oscillations, possibly improving the overall stability and precision of motor control.

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