Placental mesenchymal dysplasia differentially diagnosed from molar pregnancy by 3-D inversion mode rendering: A case report

2013 ◽  
Vol 40 (1) ◽  
pp. 284-287 ◽  
Author(s):  
Ryoko Minekawa-Mehandjiev ◽  
Kumi Masuda ◽  
Kasumi Yamamoto ◽  
Kiyonori Miura ◽  
Masahiro Nakayama ◽  
...  
Keyword(s):  
Case Report ◽  
Molar Pregnancy ◽  
Inversion Mode ◽  
Placental Mesenchymal Dysplasia

Placental mesenchymal dysplasia- A case report

2021 ◽  
Vol 6 (3) ◽  
pp. 249-252
Author(s):  
Zeba Nisar ◽  
Mahendra A Patil ◽  
Vaishali J Pol ◽  
Jaydeep N Pol
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Clinical Suspicion ◽  
Termination Of Pregnancy ◽  
Rare Disorder ◽  
Molar Pregnancy ◽  
Female Fetus ◽  
Beta Hcg ◽  
Antenatal Visits ◽  
Placental Mesenchymal Dysplasia

Placental mesenchymal dysplasia is a rare disorder mainly characterized by enlarged placenta. Patients on antenatal visits present with normal or slightly raised Beta-HCG, raised Alfa-fetoprotein and cystic structures on USG resembling a molar pregnancy. It has to be differentiated from molar pregnancies to avoid unnecessary termination of pregnancy. This condition is associated with IUGR or IUFD. Mostly the fetus are females. Due to lack of awareness of this condition it remains underreported. Here we present a case report of 20 years old female 37 week pregnant with IUGR with clinical suspicion of molar pregnancy gave birth to alive female fetus and on histopathological examination of placenta was diagnosed with PMD.

Placental mesenchymal dysplasia vs molar pregnancy: A case report

Sonography ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 137-140
Author(s):  
Philippa Jeffrey
Keyword(s):  
Case Report ◽  
Molar Pregnancy ◽  
Placental Mesenchymal Dysplasia

Placental Mesenchymal Dysplasia

2007 ◽  
Vol 131 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Zahida Parveen ◽  
Jane Elaine Tongson-Ignacio ◽  
Cory R. Fraser ◽  
Jeffery L. Killeen ◽  
Karen S. Thompson
Keyword(s):  
Differential Diagnosis ◽  
Clinical Presentation ◽  
Early Recognition ◽  
Data Sources ◽  
Molar Pregnancy ◽  
Close Attention ◽  
Normal Fetus ◽  
Fetal Complications ◽  
Microscopic Features ◽  
Placental Mesenchymal Dysplasia

Abstract Context.—Placental mesenchymal dysplasia is characterized by placentomegaly and may be mistaken for molar pregnancy both clinically and macroscopically because of the presence of “grapelike vesicles.” It may be associated with a completely normal fetus, a fetus with growth restriction, or a fetus with features of Beckwith-Wiedemann syndrome. Objective.—To review the etiology, molecular pathology, gross and microscopic features, clinical presentation, complications, and differential diagnosis of placental mesenchymal dysplasia. Data Sources.—The PubMed and the Medline databases were systematically searched for articles between 1970 and 2006. The following keywords were used: placental mesenchymal dysplasia, mesenchymal hyperplasia, molar pregnancy, pseudomolar pregnancy, Beckwith-Wiedemann syndrome, and placentomegaly. Relevant references from review articles were also searched. Conclusions.—Placental mesenchymal dysplasia should be considered in the differential diagnosis when the ultrasonographic findings show a cystic placenta. Close attention should be paid to fetal morphology for early recognition of fetal complications and to prevent unnecessary termination of pregnancy in cases associated with a normal fetus.

Placental Mesenchymal Dysplasia with Hepatic Mesenchymal Hamartoma: A Case Report and Literature Review

2013 ◽  
Vol 32 (6) ◽  
pp. 448-453 ◽  
Author(s):  
Kemoy Harris ◽  
Chrystalle Katte Carreon ◽  
Nidhi Vohra ◽  
Alex Williamson ◽  
Stephen Dolgin ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Mesenchymal Hamartoma ◽  
Placental Mesenchymal Dysplasia

Extrauterine Epithelioid Trophoblastic Tumor (ETT) Arising from an Antecedent Undiagnosed Molar Pregnancy Presenting as an Adnexal mass: A Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S78-S78
Author(s):  
J Gallardo ◽  
K Hummel ◽  
K McCluskey ◽  
R Masand ◽  
J Sunde
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Dna Fingerprinting ◽  
Adnexal Mass ◽  
Molar Pregnancy ◽  
Fingerprinting Analysis ◽  
Trophoblastic Tumor ◽  
Eosinophilic Cytoplasm ◽  
Epithelioid Trophoblastic Tumor ◽  
Β Hcg

Abstract Introduction/Objective Epithelioid trophoblastic tumor (ETT) is an extremely rare neoplasm derived from chorionic type intermediate trophoblast. ETT usually follows an antecedent term pregnancy but can also follow spontaneous abortions or molar pregnancy. ETT most often arises from the endometrium, followed by the cervix. Extrauterine ETT are extremely rare, with few cases reported in literature. Methods/Case Report A 41-year-old woman with three term pregnancies presented with abdominal pain, ten years after her last pregnancy. Imaging findings of a 3.5 cm adnexal mass coupled with an elevated serum β-hCG (~ 900 mIU/ml), led to the suspicion of an ectopic pregnancy. Hysterectomy with salpingectomy revealed a 4.7 cm, tan- yellow, necrotic mass in the adnexal region abutting but distinct from the uterine serosa. Histologic evaluation showed a well- circumscribed tumor with pushing borders. The tumor cells were epithelioid with well-defined eosinophilic cytoplasm, monomorphic nuclei, frequent mitosis, and abundant geographic necrosis. The tumor cells were positive for β-hCG, GATA-3, PLAP and inhibin, with focal weak staining squamous markers p63 and p40. DNA fingerprinting analysis, performed to confirm the diagnosis of ETT, revealed a homozygous tumor with two copies of non-maternal genes indicating that the antecedent index gestation giving rise to the tumor was an undiagnosed hydatidiform mole. Following surgery, serum β-hCG levels were normal and the patient is currently on surveillance. Results (if a Case Study enter NA) NA Conclusion We present an extremely rare case of extrauterine ETT arising from a previously undetected molar pregnancy. The diagnosis should be suspected when a mass is observed at extrauterine sites with elevated β-hCG levels in patients with or without vaginal bleeding. Histologic differential of squamous cell carcinoma needs to be ruled out with immunostains. Due to its rarity and highly variable presentation, this entity remains a diagnostic challenge. DNA fingerprinting analysis demonstrating non-maternal genes can help confirm the diagnosis of ETT.

scholarly journals A Rare Case Report of Molar Pregnancy with Coexisting Fetus

2018 ◽  
Vol 04 (01) ◽  
pp. 037-039
Author(s):  
Richa S Nathani ◽  
Zeba Nisar
Keyword(s):  
Case Report ◽  
Hydatidiform Mole ◽  
Rare Condition ◽  
Healthy Infant ◽  
Molar Pregnancy ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Optimal Outcomes ◽  
Rare Case Report ◽  
Β Hcg

Abstract Aim: Here we report a molar pregnancy with a coexisting fetus progressing to a viable, healthy infant which is an extreme rarity, with the incidence of 0.005–0.01% of all the pregnancies. Background: Partial mole is defined as excessive trophoblastic proliferation with normal and hydropic villi and presence of a fetus or a fetal circulation with nucleated cells. Partial molar pregnancy with a singleton live fetes is a rare condition. it is commonly seen with twin gestation and it is rare with singleton pregnancy Case report: A 30 years old primigravida, referred from a private hospital at 38 weeks of gestation delivered a phenotypically normal and healthy infant 2200 gm in weight by caesarean section. The placenta weighed 500 gms and on sectioning revealed widespread, grape-like vesicles. Light microscopy revealed normal villi coexisting with villi showing hydropic change and cistern formation and diffuse circumferential trophoblastic hyperplasia consistent with molar change. A diagnosis of partial molar pregnancy with normal fetus was made. Conclusion: Very few twin pregnancies with a hydatidiform mole and a foetus continue to term as they often have spontaneous or induced terminations for maternal complications Management of molar changes associated with normal appearing fetus still remains challenging as not many studies have been done due to rarity of this disorder. Clinical significance: Though the general trend is to terminate pregnancy in foetus with coexistent mole in anticipation of complications, under close surveillance, optimal outcomes can be achieved. Monitoring of serum β-hCG, serial ultrasound for fetal growth, size of molar component, and theca lutein cysts can help to predict good patient outcomes.

scholarly journals Placental Mesenchymal Dysplasia: Ultrasound Characteristics and Diagnostic Pitfalls

2020 ◽  
Vol 06 (01) ◽  
pp. E2-E3
Author(s):  
Alexandros Psarris ◽  
Michail Sindos ◽  
Ploutarchos Kourtis ◽  
Andreas Pampanos ◽  
Panagiotis Antsaklis ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Early Detection ◽  
Prenatal Testing ◽  
Molar Pregnancy ◽  
Doppler Signals ◽  
Live Fetus ◽  
Placental Thickness ◽  
Diagnostic Pitfalls ◽  
Placental Mesenchymal Dysplasia ◽  
Stem Villi

Placental mesenchymal dysplasia (PMD) is a rare, benign developmental anomaly with a reported prevalence of 0.02% (Arizawa and Nakayama, 2002). It is characterized by placentomegaly with multiple cystic lesions of the stem villi and vascular anomalies (Pawoo and Heller, 2014). Early detection of PMD has been described during routine prenatal ultrasound (Vaisbuch et al., 2009). The sonographic characteristics of PMD include increased placental thickness and multiple cystic areas within the placenta with either an absence of blood flow or with low venous Doppler signals (Vaisbuch et al., 2009). The differential diagnosis of multicystic placental lesions with the presence of a live fetus include partial molar pregnancy, multiple hematomas, chorioangioma Beckwith-Wiedemann syndrome and PMD. Chorioangiomas are well circumscribed masses within the placenta and they are characterized by the presence of a single feeding vessel with the same pulse rate as the umbilical cord (Zalel et al., 2002). Invasive prenatal testing is required for the exclusion of partial molar pregnancy and Beckwith-Wiedemann Syndrome (Vaisbuch et al., 2009). Definitive diagnosis of PMD is based on the pathologic examination of the placenta. Histology reveals aneurysm or dilated blood vessels that may be thrombosed. The stem villi are edematous and enlarged with thick-walled vessels, without trophoblastic proliferation (Pawoo and Heller, 2014). This case report highlights the significance of the early detection of PMD, illustrates the pitfalls in differential diagnosis and provides valuable insights regarding PMD management in a clinical setting.

scholarly journals P35.13: Molar Pregnancy in Caesarean scar - A case report and the role of Ultrasound as a diagnostic tool

2008 ◽  
Vol 32 (3) ◽  
pp. 436-436
Author(s):  
S. Sukumaran ◽  
R. A. Duckett ◽  
A. F. Moron
Keyword(s):  
Case Report ◽  
Diagnostic Tool ◽  
Molar Pregnancy ◽  
Caesarean Scar
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