Prenatal screening at 11-13+6 weeks in assisted reproductive technology singleton pregnancies and those conceived naturally

AbstractObjectivesThe purpose of this study was to compare the rate of preterm birth, low birth weight, and foetal growth restriction in assisted reproductive technology (ART) singleton pregnancies diagnosed with vanishing twin (VT) syndrome to those of ART pregnancies that were originally singleton pregnancies.MethodsIn this retrospective study, 177 pregnancies diagnosed with VT syndrome were matched and compared with 218 primary singleton pregnancies. The preterm birth and low birth weight rates of these two groups were evaluated. All pregnancies were conceived through ART and delivered at Peking University First Hospital and Hebei Xingtai Infertility Hospital from 2014 to 2016.ResultsThe preterm delivery rate (20.90 vs. 8.72%, p<0.05) was significantly higher in the ART singletons with VT syndrome than in the control singleton group. The proportion of low-birth-weight (<2500 g) infants was also higher in the VT group than in the primary singleton group (10.73 vs. 3.67%, p<0.05). In addition, the preterm birth rate of the naturally conceived singletons was significantly lower than that of the ART singletons (6.00 vs. 14.18%, p<0.05).ConclusionsART singleton pregnancies with VT syndrome have higher rates of preterm birth and low-birth-weight new-borns than ART pregnancies that were originally singleton pregnancies.

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Is early embryonic crowding responsible for premature delivery and low birth weight of singleton pregnancies conceived by assisted reproductive technology?

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2005.02.086 ◽

2005 ◽

Vol 193 (2) ◽

pp. 589-590 ◽

Cited By ~ 3

Author(s):

Richard P. Dickey ◽

Steven N. Taylor ◽

Peter Y. Lu ◽

Belinda M. Sartor ◽

Phillip H. Rye

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Premature Delivery ◽

Singleton Pregnancies

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Functional morphology of the placental villous tree at term singleton pregnancies, achieved by methods of assisted reproductive technology

Journal of obstetrics and women s diseases ◽

10.17816/jowd65343-51 ◽

2016 ◽

Vol 65 (3) ◽

pp. 43-51 ◽

Cited By ~ 1

Author(s):

Aleksandra K Sosnina ◽

Tatyana G Tral ◽

Julia S Krylova

Keyword(s):

Assisted Reproductive Technology ◽

Immunohistochemical Study ◽

Inflammatory Diseases ◽

Morphological Structure ◽

Study Groups ◽

Reproductive Technology ◽

Placental Insufficiency ◽

Secondary Infertility ◽

Basic Group ◽

Singleton Pregnancies

Introduction. Of special interest in the use of assisted reproductive technology techniques (ART) is the placenta as the main authority responsible for the formation and growth of the fetus. Purpose and objectives. The aim of our research is to study the morpho-functional state of placenta after pregnancy achieved by means of ART. Research objectives: histological and immunohistochemical study using the CD34, NOS-3 and HIF in these placentas. Methods. Total 98 placentas from full-term singleton pregnancies with gestational age were examined. Two study groups were formed: a basic group - the placenta from pregnancy induced methods of ART (n = 60) was divided into I subgroup, which included 30 placentas from women with primary infertility and II subgroup - 30 placentas from women with secondary infertility comparison group consisted of the placenta from the naturally ensuing pregnancy (12 placentas from primigravidae and 26 placentas from multiparous patients). Results. Histological examination of the morphological structure of the placenta was found that the incidence of chronic placental insufficiency was 1.4 times higher than in the subgroup with secondary infertility. Immunohistochemical study of placentas in the basic group, there was a significant decrease in the expression of cell adhesion marker (CD34) in the vascular epithelium chorionic villi, decreased expression of vascular tone marker (NOS-3) and increase the expression of hypoxia-inducible factor (HIF-1α) in the basic group compared to placenta s from children born naturally. Changes in the expression of the studied markers are most pronounced in the placentas from children born with secondary infertility, which is likely due to the high incidence of inflammatory diseases of the pelvic organs in this subgroup. Conclusions. Endometrial pathology in primary and secondary infertility, can cause the formation of functional disorders and morphological structure of placental complex and occurrence in the future placental insufficiency.

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