In-vitro cytotoxicity and combination effects of the docetaxel-conjugated and doxorubicin-conjugated poly(lactic acid)-poly(ethylene glycol)-folate-based polymeric micelles in human ovarian cancer cells

2017 ◽  
Vol 69 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Zahra Hami ◽  
Seyed Mahdi Rezayat ◽  
Kambiz Gilani ◽  
Mohsen Amini ◽  
Mahmoud Ghazi-Khansari
Keyword(s):  
Ovarian Cancer ◽  
Lactic Acid ◽  
Polymeric Micelles ◽  
In Vitro Cytotoxicity ◽  
Poly Lactic Acid ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers

2013 ◽  
Vol 23 (24) ◽  
pp. 6656-6662 ◽  
Author(s):  
Sun Jeong Jang ◽  
Heung Woo Choi ◽  
Doo Li Choi ◽  
Sehyeon Cho ◽  
Hong-Kun Rim ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Calcium Channel ◽  
Cancer Cells ◽  
Calcium Channel Blockers ◽  
In Vitro Cytotoxicity ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Channel Blockers

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

scholarly journals E-cadherin promotes proliferation of human ovarian cancer cells in vitro via activating MEK/ERK pathway

2012 ◽  
Vol 33 (6) ◽  
pp. 817-822 ◽  
Author(s):  
Ling-ling Dong ◽  
Lian Liu ◽  
Chun-hong Ma ◽  
Ji-sheng Li ◽  
Chao Du ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Erk Pathway ◽  
E Cadherin
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