Applications of lipid-based nanocarriers for parenteral drug delivery

This review describes the use of Lipid-based Nanocarriers (LNCs) for the parenteral delivery of pharmaceutical actives. Firstly, the two generation of LNCs such as ‘‘solid lipid nanoparticles’’ (SLNs) and ‘‘nanostructured lipid carriers’’ (NLCs) are explained in term of preparation, characterization and stability. Although the use of LNCs through parenteral administration has shown many benefits, their use is limited by opsonization, an immune process that causes their short half-life (3-5 min). Therefore, many strategies are discussed to realize “stealth” systems suitable for parenteral administration. Successfully, the requirements and applications of parenteral lipid nanoparticles are reviewed for the delivery of natural compounds, synthetic drugs and genetic materials. In the last period, the latter application has been a remarkable interest due to the numerous benefits of mRNA vaccines to fight the Covid-19 pandemic.

Healthcare Applications of Nanoemulsions

The area of healthcare needs new innovative methods and tools for improvisation and to impart better efficiencies. Nanoemulsions are pharmaceutical formulations containing nanometre-sized particles used for controlled and systemic delivery of bioactive pharmaceuticals. Various advantageous properties of nanoemulsions such as the presence of hydrophobic core region, higher stability, and smaller size have made them useful to a large extent in the biomedical field. They have been employed in transdermal drug delivery, intranasal drug delivery, pulmonary drug delivery, parenteral drug delivery, and improvised delivery of hydrophobic drugs. This chapter aims to discuss various applications of nanoemulsions in healthcare including cosmetics, antimicrobials, vaccine delivery, targeted drug delivery, gene delivery, cancer therapy, and many more in detail.

Formulation development and evaluation of medroxyprogesterone acetate injectable suspension

The aim of the present work is to develop sustained release parenteral drug delivery system of contraceptive drug i., e medroxyprogesterone acetate. The formulation was prepared by sterile combining of API and excipient powders by rapid stirring method. Different excipients used in the formulation are PEG 3350, Poloxamer -188, Polysorbate-80, Benzyl alcohol and Sodium chloride. The prepared parenteral suspension was evaluated for all official parameters like sedimentation volume, measurement of zeta potential, pH, viscosity, osmolality, dissolution, assay, particle size determination, and stability studies. The dissolution profile was found to be more when compared with the innovator formulation. Stability studies were also conducted at 25ºC / 60% RH and 40ºC / 75% RH conditions up to 3M.All the parameters evaluated are within the specified limits. Keywords: Medroxy progesterone acetate, PEG 3350, Poloxamer-188, injectable suspension.