Alteronol induces cell cycle arrest and apoptosis via increased reactive oxygen species production in human breast cancer T47D cells

2018 ◽  
Vol 70 (4) ◽  
pp. 516-524 ◽  
Author(s):  
Boxue Ren ◽  
Defang Li ◽  
Lingling Si ◽  
Yangfang Ding ◽  
Jichun Han ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Reactive Oxygen Species Production ◽  
Oxygen Species ◽  
Human Breast ◽  
Cycle Arrest ◽  
Species Production

scholarly journals IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ana Carolina Martínez-Torres ◽  
Alejandra Reyes-Ruiz ◽  
Milena Benítez-Londoño ◽  
Moises Armides Franco-Molina ◽  
Cristina Rodríguez-Padilla
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Hela Cells ◽  
Reactive Oxygen Species Production ◽  
Oxygen Species ◽  
Cycle Arrest ◽  
Regulated Cell Death ◽  
Species Production

Molecular Mechanisms of Thymoquinone as Anticancer agent

2020 ◽  
Vol 23 ◽  
Author(s):  
Fatma Ismail Alhmied ◽  
Ali Hassan Alammar ◽  
Bayan Mohammed Alsultan ◽  
Marooj Alshehri ◽  
Faheem Hyder Pottoo
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Phase Cell ◽  
Cycle Phase ◽  
Human Breast ◽  
Cycle Arrest ◽  
Phase Arrest ◽  
Anti Cancer

Abstract:: Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and down regulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27and p21 a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induced G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anti-cancer properties of thymoquinone.

Purified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cells

2012 ◽  
Vol 200 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Mundekkad Deepa ◽  
Thavamani Sureshkumar ◽  
Padikara Kutty Satheeshkumar ◽  
Sulochana Priya
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Colon Cancer Cells ◽  
Human Breast ◽  
Mulberry Leaf ◽  
Cycle Arrest

scholarly journals Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

2000 ◽  
Vol 97 (16) ◽  
pp. 9042-9046 ◽  
Author(s):  
S. Cariou ◽  
J. C. H. Donovan ◽  
W. M. Flanagan ◽  
A. Milic ◽  
N. Bhattacharya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Down Regulation ◽  
Cycle Arrest
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