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Antioxidants ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 63 ◽  
Author(s):  
You-Cheng Hseu ◽  
Xuan-Zao Chen ◽  
Yugandhar Vudhya Gowrisankar ◽  
Hung-Rong Yen ◽  
Jing-Yuan Chuang ◽  
...  

Ultraviolet A (UVA)-irradiation induced reactive oxygen species (ROS) production mediates excessive melanogenesis in skin cells leading to pigmentation. We demonstrated the depigmenting and anti-melanogenic effects of Ectoine, a natural bacterial osmolyte, in UVA-irradiated human (HaCaT) keratinocytes, and the underlying molecular mechanisms were elucidated. HaCaT cells were pre-treated with low concentrations of Ectoine (0.5–1.5 μM) and assayed for various depigmenting and anti-melanogenic parameters. This pre-treatment significantly downregulated ROS generation, α-melanocyte-stimulating hormone (α-MSH) production, and proopiomelanocortin (POMC) expression in UVA-irradiated HaCaT cells. Also, antioxidant heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase [quinone 1] (NQO-1), and γ-glutamate-cysteine ligase catalytic subunit (γ-GCLC) protein expressions were mediated via the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) whose knockdown indeed impaired this effect signifying the importance of the Nrf2 pathway. Ectoine was mediating the activation of Nrf2 via the p38, protein kinase B (also known as AKT), protein kinase C (PKC), and casein kinase II protein kinase (CKII) pathways. The conditioned medium obtained from the Ectoine pre-treated and UVA-irradiated HaCaT cells downregulated the tyrosinase, tyrosinase-related protein-1 and -2 (TRP-1/-2), cyclic AMP (c-AMP) protein kinase, c-AMP response element-binding protein (CREB), and microphthalmia-associated transcription factor (MITF) expressions leading to melanoma B16F10 cells having inhibited melanin synthesis. Interestingly, this anti-melanogenic effect in α-MSH-stimulated B16F10 cells was observable only at 50–400 μM concentrations of Ectoine, signifying the key role played by Ectoine (0.5–1 μM)-treated keratinocytes in skin whitening effects. We concluded that Ectoine could be used as an effective topical natural cosmetic agent with depigmenting and anti-melanogenic efficacy.



BMB Reports ◽  
2011 ◽  
Vol 44 (9) ◽  
pp. 572-577 ◽  
Author(s):  
Young-Hoon Lee ◽  
Jong-Su Uhm ◽  
Soo-Hyun Yoon ◽  
Ji-Young Kang ◽  
Eun-Kyung Kim ◽  
...  


FEBS Letters ◽  
2011 ◽  
Vol 585 (21) ◽  
pp. 3360-3366 ◽  
Author(s):  
Seok Young Jang ◽  
Soo Young Kim ◽  
Young-Seuk Bae


ChemInform ◽  
2010 ◽  
Vol 28 (35) ◽  
pp. no-no
Author(s):  
Y. METTEY ◽  
J.-M. VIERFOND ◽  
M. BAUDRY ◽  
C. COCHET ◽  
D. SARROUILHE




BMB Reports ◽  
2010 ◽  
Vol 43 (5) ◽  
pp. 325-329 ◽  
Author(s):  
Yun-Wha Rho ◽  
Young-Seuk Bae




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