scholarly journals Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

2019 ◽  
Vol 71 (9) ◽  
pp. 1353-1369 ◽  
Author(s):  
Tiantian Zhao ◽  
Hailong Tang ◽  
Long Xie ◽  
Yu Zheng ◽  
Zubing Ma ◽  
...  
Keyword(s):  
Scutellaria Baicalensis ◽  
Scutellaria Baicalensis Georgi ◽  
Traditional Uses ◽  
Pharmacology And Toxicology

scholarly journals Processed Scutellaria baicalensis Georgi Extract Alleviates LPS-Induced Inflammatory and Oxidative Stress through a Crosstalk between NF-κB and KEAP1/NRF2 Signaling in Macrophage Cells

2021 ◽  
Vol 11 (13) ◽  
pp. 6055
Author(s):  
Akhtar Ali ◽  
En-Hyung Kim ◽  
Jong-Hyun Lee ◽  
Kang-Hyun Leem ◽  
Shin Seong ◽  
...  
Keyword(s):  
Scutellaria Baicalensis ◽  
Raw 264.7 Cells ◽  
Prostaglandin E ◽  
Scutellaria Baicalensis Georgi ◽  
Anticancer Effects ◽  
Tnf Α ◽  
Clinical Benefits ◽  
Anti Oxidant ◽  
Cox 2 ◽  
Anti Inflammatory

Prolonged inflammation results in chronic diseases that can be associated with a range of factors. Medicinal plants and herbs provide synergistic benefits based on the interaction of multiple phytochemicals. The dried root of Scutellaria baicalensis Georgi and its compounds possess anti-inflammatory, anti-oxidative, and anticancer effects. Processing is a traditional method to achieve clinical benefits by improving therapeutic efficacy and lowering toxicity. In this study, we investigated the anti-inflammatory and anti-oxidant effect of processed Scutellaria baicalensis Georgi extract (PSGE) against lipopolysaccharide (LPS) stimulated RAW 264.7 cells. Data using Griess assay and ELISA showed that PSGE decreased nitric oxide and prostaglandin E2 (PGE2) levels against LPS. PSGE treatment up-regulated 15-hydroxyprostaglandin dehydrogenase (PGDH), while cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 expression did not change. Interestingly, PGE2 inhibition was regulated by prostaglandin catabolic enzyme 15-PGDH rather than COX-2/mPGES-1, enzymes essential for PGE2 synthesis. Additionally, PSGE-suppressed LPS-induced IL-6 and TNF-α production through NF-κB signaling. NF-κB release from an inactive complex was inhibited by HO-1 which blocked IκBα phosphorylation. The ROS levels lowered by PSGE were measured with the H2DCFDA probe. PSGE activated NRF2 signaling and increased antioxidant Hmox1, Nqo1, and Txn1 gene expression, while reducing KEAP1 expression. In addition, pharmacological inhibition of HO-1 confirmed that the antioxidant enzyme induction by PSGE was responsible for ROS reduction. In conclusion, PSGE demonstrated anti-inflammatory and anti-oxidant effects due to NRF2/HO-1-mediated NF-κB and ROS inhibition.

Interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi in multicomponent mixtures towards cholinesterase inhibition and ROS scavenging

2020 ◽  
pp. 109857
Author(s):  
Teresa Delerue ◽  
M. Fátima Barroso ◽  
Mónica Dias-Teixeira ◽  
Maria Figueiredo-González ◽  
Cristina Delerue-Matos ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Scutellaria Baicalensis ◽  
Cholinesterase Inhibition ◽  
Multicomponent Mixtures ◽  
Ros Scavenging ◽  
Scutellaria Baicalensis Georgi

scholarly journals Traditional uses, phytochemistry, pharmacology and toxicology of Lamiophlomis rotata (Benth.) Kudo: a review

RSC Advances ◽  
2020 ◽  
Vol 10 (19) ◽  
pp. 11463-11474
Author(s):  
Zhan-Hu Cui ◽  
Shuang-Shuang Qin ◽  
Er-Huan Zang ◽  
Chao Li ◽  
Li Gao ◽  
...  
Keyword(s):  
Traditional Uses ◽  
Therapeutic Drugs ◽  
Pharmacology And Toxicology

The useful information of Lamiophlomis rotata (Benth.) Kudo was summarized, which provided a basis for the development of new therapeutic drugs for this plant.

Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review

2021 ◽  
pp. 114570
Author(s):  
Rakshandha Saini ◽  
Nitin Sharma ◽  
Oluwole Solomon Oladeji ◽  
Anuradha Sourirajan ◽  
Kamal Dev ◽  
...  
Keyword(s):  
Phyllanthus Emblica ◽  
Comprehensive Review ◽  
Traditional Uses ◽  
Pharmacology And Toxicology
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