MRI findings in a young dog with gliomatosis cerebri

An 8-year-old intact male Lagotto Romagnolo was presented with forebrain signs. Neuroanatomic localization was diffuse prosencephalon. MRI revealed diffuse, bilateral, and symmetric T2 and FLAIR hyperintensities in the parieto-occipital white matter and corpus callosum. No mass effect or contrast enhancement was noted. Analysis of cerebrospinal fluid revealed normal protein content and mild mononuclear pleocytosis. Atypical cells were not identified. 15 days later because of the worsening of clinical condition the patient was euthanized upon owner’s request. Neuropathological investigations were consistent with gliomatosis cerebri (GC). Such an unusual imaging pattern appeared similar to some cases of human GC and to a previous reported case in a dog, suggesting a possible repeatable imaging findings for this rare brain neoplasm. GC should be included in the MRI differentials for diffuse bilateral white matter signal changes and specific MRI findings described in this report may help in reaching a presumptive diagnosis of this tumor.

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Multivoxel magnetic resonance spectroscopy in gliomatosis cerebri

Acta Radiologica ◽

10.1080/02841850510021751 ◽

2005 ◽

Vol 46 (6) ◽

pp. 621-624 ◽

Cited By ~ 5

Author(s):

E. Uysal ◽

M. Erturk ◽

H. Yildirim ◽

O. Karatag ◽

M. Can ◽

...

Keyword(s):

Magnetic Resonance ◽

Mr Spectroscopy ◽

Marked Decrease ◽

Gliomatosis Cerebri ◽

Contralateral Side ◽

Resonance Spectroscopy ◽

Mri Findings ◽

Diagnostic Challenge ◽

Histopathologic Evaluation ◽

Magnetic Resonance Imaging Mri

Gliomatosis cerebri is a rare entity with non-specific clinical and conventional magnetic resonance imaging (MRI) findings; accurate diagnosis is a differential diagnostic challenge. MR spectroscopy has recently been introduced as a useful diagnostic tool for detection of this entity. We present a gliomatosis cerebri case in which we made the radiological diagnosis using the MR spectroscopy findings; the diagnosis was confirmed by subsequent biopsy and histopathologic evaluation. Multivoxel spectroscopy (CSI, PRESS, 1500/135) shows a marked increase in Cho/NAA (6.6), normal to mild increase in Cho/Cr (1.2), and marked decrease in NAA/Cr (0.2) compared with the normally appearing contralateral side (Cho/NAA: 0.8, Cho/Cr: 0.9, NAA/Cr: 1.2).

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ADEM: diffusion MRI findings

European Journal of Radiology ◽

10.1016/s0720-048x(02)00180-8 ◽

2002 ◽

Author(s):

R Sener

Keyword(s):

Diffusion Mri ◽

Mri Findings

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A series of 34 patients with Rasmussen's encephalitis: Clinical course, EEG- and MRI findings

Neuropediatrics ◽

10.1055/s-0029-1215734 ◽

2008 ◽

Vol 39 (05) ◽

Author(s):

M Beckhaus ◽

F Woermann ◽

B Pohlmann-Eden

Keyword(s):

Clinical Course ◽

Mri Findings ◽

Rasmussen’S Encephalitis

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Neonatale intrazerebrale Blutung als Initialsymptom einer Gliomatosis cerebri WHO III – neurologisches Outcome nach partieller Hemisphärektomie

Klinische Pädiatrie ◽

10.1055/s-0030-1261649 ◽

2010 ◽

Vol 222 (S 01) ◽

Author(s):

A Wacker ◽

F Neunhoeffer ◽

HG Scheel- Walter ◽

J Schittenhelm ◽

BE Will

Keyword(s):

Gliomatosis Cerebri ◽

Intrazerebrale Blutung ◽

Neurologisches Outcome

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Preoperative localization of parathyroid glands

Nuklearmedizin ◽

10.1055/s-0038-1625596 ◽

2004 ◽

Vol 43 (03) ◽

pp. 85-90 ◽

Cited By ~ 27

Author(s):

E. Lopez Hänninen ◽

Th. Steinmüller ◽

T. Rohlfing ◽

H. Bertram ◽

M. Gutberlet ◽

...

Keyword(s):

Image Fusion ◽

Single Photon ◽

Imaging Techniques ◽

Photon Emission ◽

Parathyroid Glands ◽

Preoperative Localization ◽

Mri Findings ◽

99Mtc Mibi ◽

Weighted Sequences ◽

Mibi Scintigraphy

Summary Aim: Minimally invasive resection of hyperfunctional parathyroid glands is an alternative to open surgery. However, it requires a precise preoperative localization. This study evaluated the diagnostic use of magnetic resonance (MR) imaging, parathyroid scintigraphy, and consecutive image fusion. Patients, methods: 17 patients (9 women, 8 men; age: 29-72 years; mean: 51.2 years) with primary hyperparathyroidism were included. Examination by MRI used unenhanced T1- and T2-weighted sequences as well as contrast-enhanced T1-weighted sequences. 99mTc-MIBI scintigraphy consisted of planar and SPECT (single photon emission tomography) imaging techniques. In order to improve the anatomical localization of a scintigraphic focus, SPECT-data were fused with the corresponding MR-data using a modified version of the Express 5.0 software (Advanced Visual Systems, Waltham, MA). Results of image fusion were then compared to histopathology. Results: In 14/17 patients, a single parathyroid adenoma was found. There were 3 cases with hyperplastic glands. MRI detected 10 (71%), scintigraphy 12 (86%) adenomas. Both modalities detected 1/3 patients with hyperplasia. Image fusion improved the anatomical assignment of the 13 scintigraphic foci in five patients and was helpful in the interpretation of inconclusive MR-findings in two patients. Conclusions: Both MRI and 99mTc-MIBI scintigraphy sensitively detect parathyroid adenomas but are less reliable in case of hyperplastic glands. In case of a scintigraphic focus, image fusion considerably improves its topographic assignment. Furthermore, it facilitates the evaluation of inconclusive MRI findings.

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