scholarly journals Understanding the association between sleep, shift work and COVID‐19 vaccine immune response efficacy: Protocol of the S‐CORE study

2021 ◽  
Author(s):  
Heidi M. Lammers‐van der Holst ◽  
Gert Jan Lammers ◽  
Gijsbertus T. J. Horst ◽  
Inês Chaves ◽  
Rory D. Vries ◽  
...  
Keyword(s):  
Immune Response ◽  
Shift Work ◽  
Response Efficacy ◽  
Core Study

Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females? – A systematic review

Vaccine ◽  
2020 ◽  
Vol 38 (3) ◽  
pp. 444-459 ◽  
Author(s):  
Fazia Tadount ◽  
Pamela Doyon-Plourde ◽  
Ellen Rafferty ◽  
Shannon MacDonald ◽  
Manish Sadarangani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Immune Response ◽  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Seasonal Influenza Vaccine ◽  
Response Efficacy ◽  
Males And Females

scholarly journals The effects of balneotherapy on human immune gunction: should baths and mud applications have a role during covid-19 pandemic?

2020 ◽  
Vol 97 (3) ◽  
pp. 22-24
Author(s):  
M.C. Maccarone ◽  
G. Magro ◽  
U. Solimene ◽  
S. Masiero
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Stress Reduction ◽  
Direct Action ◽  
Response Efficacy ◽  
Suitable Treatment ◽  
Human Immunity ◽  
Human Immune ◽  
Pro Inflammatory Cytokines

Recent evidences show that balneotherapy applications can affect the immune system, which has an important role in the containment of Covid-19 infection outcomes. It is interesting to consider if balneotherapy, through medical water baths and mud applications can be a suitable treatment in order to influence human immunity in people who have not acquired the infection and in subjects discharged from hospital after Covid-19 recovery. In particular, balneotherapy seems to improve the immune response efficacy, with an effect mediated by mental stress reduction and a direct action, consisting in the modulation of the abnormal inflammation and the enhancement of the immune system, through changes in both cell-mediated and humoral immunity. The main changes demonstrated on human immunity, after balneotherapy, are linked to an increase in the levels and the activity of cells involved in the immune response such as neutrophils and monocytes and to a reduction of the pro-inflammatory cytokines produced by a dysregulated inflammation. Even if further in vitro researches and clinical trials on this topic should be conducted, at present Spa centres, if hygienically controlled according to WHO and national recommendations, may be considered safe places to attend and useful settings to counteract the outcomes of residual unbalanced immunity after Covid-19 infection.

Night shift work and immune response to the meningococcal conjugate vaccine in healthy workers: a proof of concept study

2020 ◽  
Vol 75 ◽  
pp. 263-275
Author(s):  
Francieli S. Ruiz ◽  
Daniela S. Rosa ◽  
Ioná Z. Zimberg ◽  
Marcus VL. dos Santos Quaresma ◽  
Jethe OF. Nunes ◽  
...  
Keyword(s):  
Immune Response ◽  
Conjugate Vaccine ◽  
Shift Work ◽  
Night Shift ◽  
Proof Of Concept ◽  
Night Shift Work ◽  
Concept Study

scholarly journals Modeling the circadian regulation of the immune system: Sexually dimorphic effects of shift work

2021 ◽  
Vol 17 (3) ◽  
pp. e1008514
Author(s):  
Stéphanie M. C. Abo ◽  
Anita T. Layton
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Circadian Clock ◽  
Shift Work ◽  
Clock Genes ◽  
Dynamic Change ◽  
Female Rats ◽  
Integrative Model ◽  
Shift Workers ◽  
Males And Females

The circadian clock exerts significance influence on the immune system and disruption of circadian rhythms has been linked to inflammatory pathologies. Shift workers often experience circadian misalignment as their irregular work schedules disrupt the natural light-dark cycle, which in turn can cause serious health problems associated with alterations in genetic expressions of clock genes. In particular, shift work is associated with impairment in immune function, and those alterations are sex-specific. The goal of this study is to better understand the mechanisms that explain the weakened immune system in shift workers. To achieve that goal, we have constructed a mathematical model of the mammalian pulmonary circadian clock coupled to an acute inflammation model in the male and female rats. Shift work was simulated by an 8h-phase advance of the circadian system with sex-specific modulation of clock genes. The model reproduces the clock gene expression in the lung and the immune response to various doses of lipopolysaccharide (LPS). Under normal conditions, our model predicts that a host is more sensitive to LPS at circadian time (CT) CT12 versus CT0 due to a dynamic change of Interleukin 10 (IL-10), an anti-inflammatory cytokine. We identify REV-ERB as a key modulator of IL-10 activity throughout the circadian day. The model also predicts a reversal of the times of lowest and highest sensitivity to LPS, with males and females exhibiting an exaggerated response to LPS at CT0, which is countered by a blunted immune response at CT12. Overall, females produce fewer pro-inflammatory cytokines than males, but the extent of sequelae experienced by males and females varies across the circadian day. This model can serve as an essential component in an integrative model that will yield mechanistic understanding of how shift work-mediated circadian disruptions affect the inflammatory and other physiological responses.

Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs

1999 ◽  
Vol 37 (2) ◽  
pp. 123-129 ◽  
Author(s):  
B. R. Mignon ◽  
T. Leclipteux ◽  
CH. Focant ◽  
A. J. Nikkels ◽  
G. E. PIErard ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Guinea Pigs ◽  
Microsporum Canis ◽  
Cellular Immune

Adverse effects of shift work in healthcare professionals

2003 ◽  
Vol 3 (2) ◽  
pp. 293-309
Author(s):  
S PATEL ◽  
E OMALLEY
Keyword(s):  
Adverse Effects ◽  
Shift Work ◽  
Healthcare Professionals

Abstract #418: Effect of Testosterone (T) Replacement with a T-Gel or a New Oral T Formulation (Rextoro) on Selected Biomarkers of Endothelial Injury and Immune Response to Lipids

2015 ◽  
Vol 21 ◽  
pp. 93
Author(s):  
Merrell Magelli ◽  
Ronald Swerdloff ◽  
John Amory ◽  
Gregory Flippo ◽  
Wael Salameh ◽  
...  
Keyword(s):  
Immune Response ◽  
Endothelial Injury

Author response for "Diabetes alters immune response patterns to acute melioidosis in humans"

2019 ◽  
Author(s):  
Barbara Kronsteiner ◽  
Panjaporn Chaichana ◽  
Manutsanun Sumonwiriya ◽  
Kemajitra Jenjaroen ◽  
Fazle Rabbi Chowdhury ◽  
...  
Keyword(s):  
Immune Response ◽  
Author Response ◽  
Response Patterns
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