Literature review of 10 plants products for their anti-inflammatory, antioxidant, immunomodulatory, and antiviral properties

The global health pandemic of coronavirus disease (Covid-19) did not have specifically approved medication for the treatment. To maintain the human immunity power by natural remedies is the only way to prevent coronavirus infection. We designed a study protocol by selecting 10 natural plant active constituents that were claimed by traditional and investigational ways to have anti-inflammatory, antioxidant, immunomodulatory, and antiviral properties. We will analyze these selected 10 plants' active constituents by molecular docking analysis. This article is a literature review of selected 10 plants products including Coffea Arabica, Curcuma longa, Glycyrrhiza glabra, Zizyphus vulgaris, Sisymbrium irio, Borago officinalis, Althaea officinalis, Malva sylvestris, Cordia Latifolia, and Adhatoda vasica for their anti-inflammatory, antioxidant, immunomodulatory, and antiviral properties.

Internet Rumors During the COVID-19 Pandemic: Dynamics of Topics and Public Psychologies

The capturing of social opinions, especially rumors, is a crucial issue in digital public health. With the outbreak of the COVID-19 pandemic, the discussions of related topics have increased exponentially in social media, with a large number of rumors on the Internet, which highly impede the harmony and sustainable development of society. As human health has never suffered a threat of this magnitude since the Internet era, past studies have lacked in-depth analysis of rumors regarding such a globally sweeping pandemic. This text-based analysis explores the dynamic features of Internet rumors during the COVID-19 pandemic considering the progress of the pandemic as time-series. Specifically, a Latent Dirichlet Allocation (LDA) model is used to extract rumor topics that spread widely during the pandemic, and the extracted six rumor topics, i.e., “Human Immunity,” “Technology R&D,” “Virus Protection,” “People's Livelihood,” “Virus Spreading,” and “Psychosomatic Health” are found to show a certain degree of concentrated distribution at different stages of the pandemic. Linguistic Inquiry and Word Count (LIWC) is used to statistically test the psychosocial dynamics reflected in the rumor texts, and the results show differences in psychosocial characteristics of rumors at different stages of the pandemic progression. There are also differences in the indicators of psychosocial characteristics between truth and disinformation. Our results reveal which topics of rumors and which psychosocial characteristics are more likely to spread at each stage of progress of the pandemic. The findings contribute to a comprehensive understanding of the changing public opinions and psychological dynamics during the pandemic, and also provide reference for public opinion responses to major public health emergencies that may arise in the future.

The Effect of Nanogold-Nanosilver to Boost Immunity in People Affected (Reactive and Positive) by Covid-19

COVID-19 virus outbreak was first found in Wuhan China. The current COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-CoV-2). The interaction of the virus with the immune system causes the immunity of people affected by the outbreak to decrease. The combination of nanogold and nanosilver, that is an antimicrobial and antiviral agent, can inhibit the replication of the COVID-19 virus an d act as drug delivery. This research aims to determine the effect of nanogold-nanosilver that can increase immunity in people who are positively affected by the COVID-19 virus. The method used in this research was quantitative descriptive by describing the effect of the nanogold-nanosilver health drink given to increasing human immunity exposed to the COVID-19 virus seen from the number of respondent cures. The respondents consumed 500 mL of health drinks containing nanogold and nanosilver compounds with a concentration of 2 ppm per day. Based on the data obtained, the combination of nanogold and nanosilver could increase the immunity of people affected by COVID-19, marked by physical changes that became healthier, fitter and negative swab test results and accelerate the healing of COVID-19 patients.

“World in motion” – emulsion adjuvants rising to meet the pandemic challenges

Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as key components of licensed vaccines, with over 100 million doses administered to diverse populations in more than 30 countries. Substantial clinical experience of effectiveness and a well-established safety profile, along with the ease of manufacturing have established emulsion adjuvants as one of the leading platforms for the development of pandemic vaccines. Emulsion adjuvants allow for antigen dose sparing, more rapid immune responses, and enhanced quality and quantity of adaptive immune responses. The mechanisms of enhancement of immune responses are well defined and typically characterized by the creation of an “immunocompetent environment” at the site of injection, followed by the induction of strong and long-lasting germinal center responses in the draining lymph nodes. As a result, emulsion adjuvants induce distinct immunological responses, with a mixed Th1/Th2 T cell response, long-lived plasma cells, an expanded repertoire of memory B cells, and high titers of cross-neutralizing polyfunctional antibodies against viral variants. Because of these various properties, emulsion adjuvants were included in pandemic influenza vaccines deployed during the 2009 H1N1 influenza pandemic, are still included in seasonal influenza vaccines, and are currently at the forefront of the development of vaccines against emerging SARS-CoV-2 pandemic variants. Here, we comprehensively review emulsion adjuvants, discuss their mechanism of action, and highlight their profile as a benchmark for the development of additional vaccine adjuvants and as a valuable tool to allow further investigations of the general principles of human immunity.

Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity

Probiotics are beneficial active microorganisms that colonize the human intestines and change the composition of the flora in particular parts of the host. Recently, the use of probiotics to regulate intestinal flora to improve host immunity has received widespread attention. Recent evidence has shown that probiotics play significant roles in gut microbiota composition, which can inhibit the colonization of pathogenic bacteria in the intestine, help the host build a healthy intestinal mucosa protective layer, and enhance the host immune system. Based on the close relationship between the gut microbiota and human immunity, it has become an extremely effective way to improve human immunity by regulating the gut microbiome with probiotics. In this review, we discussed the influence of probiotics on the gut microbiota and human immunity, and the relationship between immunity, probiotics, gut microbiota, and life quality. We further emphasized the regulation of gut microflora through probiotics, thereby enhancing human immunity and improving people’s lives.

Bacterial Atlas of Mouse Gut Microbiota

Background: Mouse model is one of of the most widely used animal models for exploring the roles of human gut microbiota, a complex system involving in human immunity and metabolism. However, the structure of mouse gut bacterial community has not been explored at a large scale. To address this concern, the diversity and composition of the gut bacteria of 600 mice was characterized in this study. Results: The results showed that the bacteria belonging to 8 genera were found in the gut microbiota of all mouse individuals, indicating that the 8 bacteria were the core bacteria of mouse gut microbiota. The dominant genera of the mouse gut bacteria contained 15 bacterial genera. It was found that the bacteria in the gut microbiota were mainly involved in host’s metabolisms via the collaborations between the gut bacteria. The further analysis demonstrated that the composition of mouse gut microbiota was similar to that of human gut microbiota. Conclusion: Our study presented a bacterial atlas of mouse gut microbiota, providing a solid basis for investing the bacterial communities of mouse gut microbiota.

Analysis of SIS-SI Stochastic Model with CTMC on the Spread of Malaria Disease

Various mathematical models have been developed to describe the transmission of malaria disease. The purpose of this study was to modify an existing mathematical model of malaria disease by using a CTMC stochastic model. The investigation focused on the transition probability, the basic reproduction number (R0), the outbreak probability, the expected time required to reach a disease-free equilibrium, and the quasi-stationary probability distribution. The population system will experience disease outbreak if R0>1, whereas an outbreak will not occur in the population system if R0≤1. The probability that a mosquito bites an infectious human is denoted as k, while θ is associated with human immunity. Based on the numerical analysis conducted, k and θ have high a contribution to the distribution of malaria disease. This conclusion is based on their impact on the outbreak probability and the expected time required to reach a disease-free equilibrium.