Single-nucleotide substitution of Hepatitis B virus in intrauterine infection

2014 ◽  
Vol 22 (4) ◽  
pp. 433-440 ◽  
Author(s):  
L.-J. Wang ◽  
Y.-F. Xu ◽  
X.-X. Liu ◽  
Y. Chen
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleotide Substitution ◽  
Intrauterine Infection ◽  
Single Nucleotide Substitution ◽  
Single Nucleotide ◽  
B Virus

The study on the role of Hepatitis B virus X protein and apoptosis in HBV intrauterine infection

2011 ◽  
Vol 285 (4) ◽  
pp. 943-949 ◽  
Author(s):  
Guiqin Bai ◽  
Yueling Wang ◽  
Lingyan Zhang ◽  
Yao Tang ◽  
Fengping Fu
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Intrauterine Infection ◽  
X Protein ◽  
B Virus

scholarly journals Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yang Zhuo ◽  
Yalan Yang ◽  
Mingjun Zhang ◽  
Ying Xu ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Signaling Pathway ◽  
Public Health Problem ◽  
Hbv Infection ◽  
Nucleotide Polymorphisms ◽  
Breakthrough Infection ◽  
Single Nucleotide ◽  
B Virus

Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450–0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205–0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

scholarly journals Poly-linker primer system for detection of single nucleotide polymorphisms and its application in genotyping hepatitis B virus

2014 ◽  
Vol 47 (2) ◽  
pp. 139-141
Author(s):  
Yongzhong Wang ◽  
Bo-Yu Xue ◽  
Longgen Liu ◽  
Zhen Zhu ◽  
Xin Xu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
B Virus

Genetic variations in LTA gene and PDCD1 gene and intrauterine infection of hepatitis B virus: a case–control study in China

Amino Acids ◽  
2018 ◽  
Vol 50 (7) ◽  
pp. 877-883 ◽  
Author(s):  
Tingting Liu ◽  
Zhihua Wan ◽  
Songxu Peng ◽  
Yanni Wang ◽  
Hongyan Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Intrauterine Infection ◽  
Case Control ◽  
Genetic Variations ◽  
B Virus ◽  
Control Study

scholarly journals Mechanism of intrauterine infection of hepatitis B virus

2004 ◽  
Vol 10 (3) ◽  
pp. 437 ◽  
Author(s):  
Shu-Lin Zhang ◽  
Ya-Fei Yue ◽  
Gui-Qin Bai ◽  
Lei Shi ◽  
Hui Jiang
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Intrauterine Infection ◽  
B Virus

scholarly journals Role of GSPT1 and GSPT2 polymorphisms in different outcomes upon Hepatitis B virus infection and prognosis to lamivudine therapy

2019 ◽  
Vol 39 (3) ◽  
Author(s):  
Wenxuan Liu ◽  
Ning Ma ◽  
Xia Gao ◽  
Wencong Liu ◽  
Jinhai Jia ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Lamivudine Therapy ◽  
Single Nucleotide ◽  
Tumor Susceptibility ◽  
B Virus ◽  
First Time

Abstract Purpose. ERF3, having been found expressing differently in liver tissues in our previous work, including eRF3a and eRF3b, which are structural homologs named GSPT1 and GSPT2. Recent studies have indicated that eRF3b involved in the development and proliferation of HepG2 cell, and eRF3a may be associated with tumor susceptibility. Based on this, we tested the effects of GSPT1 and GSPT2 single-nucleotide polymorphisms for all major Hepatitis B virus (HBV) outcomes and lamivudine (LAM) treatment in Han Chinese. Method. A total of 1649 samples were enrolled, and peripheral blood samples were collected in the present study. The single-nucleotide polymorphisms in the GSPT1 and GSPT2 region were genotyped using MALDI-TOF MS. Results. Our study demonstrated there was no obvious relevance of either GSPT1-rs33635 or GSPT2-rs974285 polymorphisms with HBV susceptibility, spontaneous recovery, and development of HBV-related diseases. However, we showed for the first time to our knowledge that GSPT1-rs33635C was a predictor for LAM therapy (viral response: odds ratio (OR) = 2.436, P=0.022; biochemical response: OR = 3.328, P=1.73 × 10−4). Conclusions. These findings might provide potential implications for therapeutic guidance.

scholarly journals Association between genomic heterogeneity of hepatitis B virus and intrauterine infection

Virology ◽  
2009 ◽  
Vol 387 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Hai Cheng ◽  
Haixia Su ◽  
Suping Wang ◽  
Zhongjun Shao ◽  
Ke Men ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Intrauterine Infection ◽  
B Virus
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