scholarly journals A retrospective case series of clinical signs in 28 Beagles with Lafora disease

2021 ◽  
Author(s):  
Thomas Flegel ◽  
Marion Kornberg ◽  
Franziska Mühlhause ◽  
Sophie Neumann ◽  
Andrea Fischer ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Case Series ◽  
Lafora Disease ◽  
Retrospective Case ◽  
Retrospective Case Series

Evaluation of Zoledronate as Treatment for Hypercalcemia in Four Dogs

2018 ◽  
Vol 54 (6) ◽  
Author(s):  
Ashley Schenk ◽  
Cassie Lux ◽  
Jeanne Lane ◽  
Olya Martin
Keyword(s):  
Renal Failure ◽  
Hypersensitivity Reaction ◽  
Clinical Signs ◽  
Case Series ◽  
Ionized Calcium ◽  
Retrospective Case ◽  
Biochemical Abnormality ◽  
Retrospective Case Series ◽  
Life Threatening

ABSTRACT Hypercalcemia is a biochemical abnormality that, when left untreated, can lead to life-threatening complications including renal failure. Bisphosphonates are routinely used to treat hypercalcemia, but most literature on veterinary patients describes the use of pamidronate. This retrospective case series describes the use of zoledronate for treatment of hypercalcemia in four dogs. Information including signalment, clinical signs, treatment, and outcome was collected. All dogs showed a decrease in total and ionized calcium concentrations after treatment with zoledronate. All treatments of zoledronate administered were well tolerated, but a previously unreported local hypersensitivity reaction was observed in one dog. This report is the first to document the efficacy of zoledronate for treatment of hypercalcemia in dogs.

scholarly journals Continuous digital hypothermia in the prevention and treatment of acute equine laminitis

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Karen Pickering ◽  
Joanne Ireland
Keyword(s):  
Clinical Outcome ◽  
Ambient Temperature ◽  
Research Question ◽  
Experimental Studies ◽  
Clinical Signs ◽  
Case Series ◽  
Supportive Treatment ◽  
Retrospective Case ◽  
Bottom Line ◽  
Retrospective Case Series

PICO question Does continuous digital hypothermia improve clinical outcome in equids with acute laminitis compared to supportive treatment alone?   Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Six experimental randomised controlled trials and one multicentre retrospective case series were reviewed Strength of evidence Moderate Outcomes reported The outcomes reported were reduced severity of histopathological lamellar lesions in limbs treated with continuous digital hypothermia (CDH; initiated prior to or soon after the onset of experimentally induced acute laminitis) compared to limbs remaining at an ambient temperature in all five experimental studies where histology was performed. A significant reduction was observed in the prevalence or severity of clinical signs of laminitis in limbs treated with CDH compared to limbs remaining at an ambient temperature. In a single retrospective case series, significantly reduced prevalence of clinical laminitis was reported amongst animals receiving CDH compared to those that did not in a referral hospital population of animals treated for colitis Conclusion There is moderate evidence to support that CDH when used prior to or in the early stages of clinical signs, may reduce the severity and progression of lamellar lesions in acute laminitis and no evidence demonstrating that it improves clinical outcome compared to supportive treatment alone. Further research into the clinical outcome of equids treated for acute laminitis using CDH is warranted   How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.  

Management of isoniazid-monoresistant tuberculosis (Hr-TB) in Queensland, Australia: a retrospective case series

2020 ◽  
Vol 173 ◽  
pp. 106163
Author(s):  
Malcolm Wilson ◽  
Bridget O'Connor ◽  
Nicholas Matigian ◽  
Geoffrey Eather
Keyword(s):  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series

Non-vascularized fibular autograft for resistant humeral diaphyseal nonunion: Retrospective case series

2021 ◽  
pp. 102843
Author(s):  
Ahmed Fathy Sadek ◽  
Ezzat Hassan Fouly ◽  
Ahmad Fouad Abdelbaki Allam ◽  
Alaa Zenhom Mahmoud
Keyword(s):  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Fibular Autograft

scholarly journals Paediatric admissions to a district general hospital adult intensive care unit over a six year period: A single centre retrospective case series, with review of practitioner confidence and competence in paediatric critical care

2021 ◽  
pp. 175114372110121
Author(s):  
Stephen A Spencer ◽  
Joanna S Gumley ◽  
Marcin Pachucki
Keyword(s):  
Critical Care ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Case Series ◽  
Critically Ill Children ◽  
Single Centre ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
Paediatric Critical Care ◽  
Doctors And Nurses

Background Critically ill children presenting to district general hospitals (DGH) are admitted to adult intensive care units (AICUs) for stabilisation prior to transfer to paediatric intensive care units (PICUs). Current training in PICU for adult intensive care physicians is only three months. This single centre retrospective case series examines the case mix of children presenting to a DGH AICU and a multidisciplinary survey assesses confidence and previous experience, highlighting continued training needs for DGH AICU staff. Methods all paediatric admissions to AICU and paediatric retrievals were reviewed over a 6-year period (2014-2019). Cases were identified from the Electronic Patient Record (EPR) and from data provided by the regional paediatric retrieval service. A questionnaire survey was sent to AICU doctors and nurses to assess confidence and competence in paediatric critical care. Results Between 2014-2019, 284 children were managed by AICU. In total 35% of cases were <1 y, 48% of cases were <2 y and 64% of cases were <5 y, and 166/284 (58%) children were retrieved. Retrieval reduced with increasing age (OR 0.49 [0.40-0.60], p < 0.0001). The survey had an 82% response rate, and highlighted that only 13% of AICU nurses and 50% of doctors had received prior PICU training. Conclusion At least one critically unwell child presents to the AICU each week. Assessment, stabilisation and management of critically unwell children are vital skills for DGH AICU staff, but confidence and competence are lacking. Formalised strategies are required to develop and maintain paediatric competencies for AICU doctors and nurses.

scholarly journals Neoplasia within the equine foot: A retrospective case series of four horses

2021 ◽  
Author(s):  
C. Osborne ◽  
Y. A. Elce ◽  
L. Meehan ◽  
A. J. Davern ◽  
T. B. Lescun
Keyword(s):  
Case Series ◽  
Retrospective Case ◽  
Retrospective Case Series

Outcomes of combined gonioscopy-assisted transluminal trabeculotomy and goniosynechialysis in primary angle closure: a retrospective case series

2021 ◽  
Author(s):  
Tanate Chira-adisai ◽  
Kazuhiko Mori ◽  
Akane Kobayashi ◽  
Morio Ueno ◽  
Yoko Ikeda ◽  
...  
Keyword(s):  
Case Series ◽  
Angle Closure ◽  
Retrospective Case ◽  
Primary Angle Closure ◽  
Retrospective Case Series
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