Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: Effect of feeding and dose proportionality

2018 ◽  
Vol 41 (3) ◽  
pp. 457-462 ◽  
Author(s):  
R. Akabane ◽  
T. Sato ◽  
A. Sakatani ◽  
Y. Miyagawa ◽  
H. Tazaki ◽  
...  
Keyword(s):  
Single Dose ◽  
Dose Proportionality ◽  
Healthy Dogs ◽  
Effect Of Feeding

EFFECT OF FEEDING ETHINYLOESTRADIOL FOR VARIOUS PERIODS BEFORE MATING ON REPRODUCTION IN THE HAMSTER

1972 ◽  
Vol 70 (3) ◽  
pp. 582-590
Author(s):  
B. K. Davis ◽  
I. Noske ◽  
M. C. Chang
Keyword(s):  
Single Dose ◽  
Pregnancy Rate ◽  
Fertility Control ◽  
Normal Pregnancy ◽  
Oestrous Cycle ◽  
The Other ◽  
Feeding Schedule ◽  
Crown Rump Length ◽  
Essentially Normal ◽  
Effect Of Feeding

ABSTRACT Ethinyloestradiol (EO) fed for various periods before mating to female hamsters affected the timing of mating and pregnancy rate. Slight effects on ovulation, foetal-crown rump length and resorption may have occurred, but effects on implantation were not apparent among pregnant hamsters. The response observed depended upon the feeding schedule adopted: hamsters fed 2.5 mg EO in a single dose, on day 3 before mating, mated normally but had a significantly lower pregnancy rate; on the other hand, animals fed 2.5 mg EO (0.21 mg/day) over three oestrous cycles, days 14–3 before mating, showed variations in the time of mating but had an essentially normal pregnancy rate; and, a group of hamsters who received the same total amount of EO (0.63 mg/day) over one oestrous cycle, days 6–3 premating, showed untowards effects by the steroid on both the timing of mating and pregnancy rate. The implications of these results are considered in relation to fertility control.

scholarly journals Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

Animals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 832 ◽  
Author(s):  
Kelly A. Deabold ◽  
Wayne S. Schwark ◽  
Lisa Wolf ◽  
Joseph J. Wakshlag
Keyword(s):  
Single Dose ◽  
Adverse Effects ◽  
Safety Data ◽  
Area Under The Curve ◽  
Pet Owners ◽  
Dose Oral ◽  
Oral Pharmacokinetics ◽  
Healthy Dogs ◽  
Clinically Significant

The use of CBD-rich hemp products is becoming popular among pet owners with no long-term safety data related to consumption in adult dogs and cats. The purpose of this study was to determine the single-dose oral pharmacokinetics of CBD, and to provide a preliminary assessment of safety and adverse effects during 12-week administration using a hemp-based product in healthy dogs and cats. Eight of each species were provided a 2 mg/kg total CBD concentration orally twice daily for 12 weeks with screening of single-dose pharmacokinetics in six of each species. Pharmacokinetics revealed a mean maximum concentration (Cmax) of 301 ng/mL and 43 ng/mL, area under the curve (AUC) of 1297 ng-h/mL and 164 ng-h/mL, and time to maximal concentration (Tmax) of 1.4 h and 2 h, for dogs and cats, respectively. Serum chemistry and CBC results showed no clinically significant alterations, however one cat showed a persistent rise in alanine aminotransferase (ALT) above the reference range for the duration of the trial. In healthy dogs and cats, an oral CBD-rich hemp supplement administered every 12 h was not detrimental based on CBC or biochemistry values. Cats do appear to absorb or eliminate CBD differently than dogs, showing lower serum concentrations and adverse effects of excessive licking and head-shaking during oil administration.

Pharmacokinetics and Dose Proportionality of Fentanyl Sublingual Spray: a Single-Dose 5-Way Crossover Study

2013 ◽  
Vol 33 (6) ◽  
pp. 391-400 ◽  
Author(s):  
Neha Parikh ◽  
Venkat Goskonda ◽  
Ashok Chavan ◽  
Larry Dillaha
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Dose Proportionality

Pharmacokinetics and pharmacodynamics of a single dose of zoledronate in healthy dogs

2007 ◽  
Vol 30 (5) ◽  
pp. 492-495 ◽  
Author(s):  
T. MARTÍN-JIMÉNEZ ◽  
L.-P. DE LORIMIER ◽  
T. M. FAN ◽  
K. J. FREISE
Keyword(s):  
Single Dose ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Healthy Dogs

Single-dose pharmacokinetics and dose proportionality of intravenous pazufloxacin mesilate in healthy Korean volunteers

2012 ◽  
Vol 8 (8) ◽  
pp. 921-928 ◽  
Author(s):  
Joomi Lee ◽  
Sook Jin Seong ◽  
Mi-sun Lim ◽  
Sung Min Park ◽  
Jeonghyeon Park ◽  
...  
Keyword(s):  
Single Dose ◽  
Dose Proportionality ◽  
Pazufloxacin Mesilate

Effect of feeding cod liver oil on the fate of radiotocopherol in sheep

1970 ◽  
Vol 48 (11) ◽  
pp. 751-757 ◽  
Author(s):  
M. Hidiroglou ◽  
K. J. Jenkins ◽  
J. R. Lessard ◽  
E. Borowsky
Keyword(s):  
Single Dose ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Column Chromatography ◽  
Experimental Period ◽  
Cod Liver Oil ◽  
The Difference ◽  
Layer Chromatography ◽  
Effect Of Feeding ◽  
Radioactivity Levels

The metabolism of a single dose of 3H-DL-α-tocopherol was studied in 16 sheep fed a dystrophy-producing hay alone or supplemented with cod liver oil. During the experimental period, which lasted for 5 days after the radioisotope dosing, radioactivity was higher in the rumen liquor of cod liver oil fed sheep than in those which received only hay. Significantly lower levels of radioactivity were found in the non-saponifiable material of various tissues of cod liver oil fed sheep than in the corresponding tissues of the unsupplemented animals. By means of column chromatography, thin layer chromatography, and radioautography the bulk of liver radioactivity was identified as unchanged α-tocopherol. Possible reasons for the difference in tissue radioactivity levels between cod liver oil fed and unsupplemented sheep are discussed.

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