scholarly journals Vascular Inward Rectifier K+Channels as External K+Sensors in the Control of Cerebral Blood Flow

2015 ◽  
Vol 22 (3) ◽  
pp. 183-196 ◽  
Author(s):  
Thomas A. Longden ◽  
Mark T. Nelson
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Inward Rectifier ◽  
K Channels ◽  
External K

scholarly journals Aging Alters Cerebrovascular Endothelial GPCR and K+ Channel Function: Divergent Role of Biological Sex

2019 ◽  
Vol 75 (11) ◽  
pp. 2064-2073 ◽  
Author(s):  
Md A Hakim ◽  
Phoebe P Chum ◽  
John N Buchholz ◽  
Erik J Behringer
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Old Age ◽  
Purinergic Receptor ◽  
K Channel ◽  
K Channels ◽  
Nitric Oxide Signaling ◽  
Channel Function ◽  
Age Related ◽  
Kir Channel

Abstract Age-related dementia entails impaired blood flow to and throughout the brain due, in part, to reduced endothelial nitric oxide signaling. However, it is unknown whether sex affects cerebrovascular Gq-protein-coupled receptors (GPCRs) and K+ channels underlying endothelium-derived hyperpolarization (EDH) during progressive aging. Thus, we simultaneously evaluated intracellular Ca2+ ([Ca2+]i) and membrane potential (Vm) of intact endothelial tubes freshly isolated from posterior cerebral arteries of young (4–6 mo), middle-aged (12–16 mo), and old (24–28 mo) male and female C57BL/6 mice. Purinergic receptor function (vs. muscarinic) was dominant and enhanced for [Ca2+]i increases in old females versus old males. However, Ca2+-sensitive K+ channel function as defined by NS309-evoked Vm hyperpolarization was mildly impaired in females versus males during old age. This sex-based contrast in declined function of GPCRs and K+ channels to produce EDH may support a greater ability for physiological endothelial GPCR function to maintain optimal cerebral blood flow in females versus males during old age. As reflective of the pattern of cerebral blood flow decline in human subjects, inward-rectifying K+ (KIR) channel function decreased with progressive age regardless of sex. Combined age-related analyses masked male versus female aging and, contrary to expectation, hydrogen peroxide played a minimal role. Altogether, we conclude a sex-based divergence in cerebrovascular endothelial GPCR and K+ channel function while highlighting a previously unidentified form of age-related endothelial dysfunction as reduced KIR channel function.

scholarly journals Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function

2016 ◽  
Vol 36 (7) ◽  
pp. 1195-1201 ◽  
Author(s):  
Gro Klitgaard Povlsen ◽  
Thomas A Longden ◽  
Adrian D Bonev ◽  
David C Hill-Eubanks ◽  
Mark T Nelson
Keyword(s):  
Blood Flow ◽  
Smooth Muscle ◽  
Cerebral Blood Flow ◽  
Cerebral Ischemia ◽  
Therapeutic Strategies ◽  
Inward Rectifier ◽  
Global Cerebral Ischemia ◽  
Channel Function ◽  
Transient Global Cerebral Ischemia ◽  
Kir Channel

Transient global cerebral ischemia is often followed by delayed disturbances of cerebral blood flow, contributing to neuronal injury. The pathophysiological processes underlying such disturbances are incompletely understood. Here, using an established model of transient global cerebral ischemia, we identify dramatically impaired neurovascular coupling following ischemia. This impairment results from the loss of functional inward rectifier potassium (KIR) channels in the smooth muscle of parenchymal arterioles. Therapeutic strategies aimed at protecting or restoring cerebrovascular KIR channel function may therefore improve outcomes following ischemia.

scholarly journals Activity of Inwardly Rectifying K + Channels in Cerebral Arteries is Diminished in Dyslipidemia Without Overt Effects on Cerebral Blood Flow

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Paulina Kowalewska ◽  
Maria Sancho ◽  
Sergio Fabris ◽  
Murray Huff ◽  
Robert Gros ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Arteries ◽  
K Channels ◽  
Inwardly Rectifying

Equol increases cerebral blood flow in rats via activation of large-conductance Ca 2+ -activated K + channels in vascular smooth muscle cells

2016 ◽  
Vol 107 ◽  
pp. 186-194 ◽  
Author(s):  
Wei Yu ◽  
Yan Wang ◽  
Zheng Song ◽  
Li-Mei Zhao ◽  
Gui-Rong Li ◽  
...  
Keyword(s):  
Blood Flow ◽  
Smooth Muscle ◽  
Cerebral Blood Flow ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
K Channels

Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K+ channels

2007 ◽  
Vol 454 (6) ◽  
pp. 1023-1030 ◽  
Author(s):  
Won Sun Park ◽  
Youn Kyoung Son ◽  
Nari Kim ◽  
Jae-Hong Ko ◽  
Sung Hyun Kang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Acute Hypoxia ◽  
Inward Rectifier ◽  
K Channels

Alterations in regional decreased cerebral blood flow in patients with irritable bowel syndrome-A PET imaging study

2001 ◽  
Vol 120 (5) ◽  
pp. A637-A637
Author(s):  
Y RINGEL ◽  
D DROSSMAN ◽  
T TURKINGTON ◽  
B BRADSHAW ◽  
R COLEMAN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Irritable Bowel Syndrome ◽  
Cerebral Blood Flow ◽  
Pet Imaging ◽  
Imaging Study ◽  
Irritable Bowel
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