Serum sclerostin values are associated with abdominal aortic calcification and predict cardiovascular events in patients with chronic kidney disease stages 3-5D

Nephrology ◽  
2017 ◽  
Vol 22 (4) ◽  
pp. 286-292 ◽  
Author(s):  
Xue-Rong Wang ◽  
Liang Yuan ◽  
Jing-Jing Zhang ◽  
Li Hao ◽  
De-Guang Wang
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular Events ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
Disease Stages

scholarly journals Prognostic Value of Abdominal Aortic Calcification: A Systematic Review and Meta‐Analysis of Observational Studies

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Kevin Leow ◽  
Pawel Szulc ◽  
John T. Schousboe ◽  
Douglas P. Kiel ◽  
Armando Teixeira‐Pinto ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular Events ◽  
Meta Analysis ◽  
The Elderly ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Random Effects Models ◽  
Abdominal Aortic ◽  
All Cause Mortality

Background The prognostic importance of abdominal aortic calcification (AAC) viewed on noninvasive imaging modalities remains uncertain. Methods and Results We searched electronic databases (MEDLINE and Embase) until March 2018. Multiple reviewers identified prospective studies reporting AAC and incident cardiovascular events or all‐cause mortality. Two independent reviewers assessed eligibility and risk of bias and extracted data. Summary risk ratios (RRs) were estimated using random‐effects models comparing the higher AAC groups combined (any or more advanced AAC) to the lowest reported AAC group. We identified 52 studies (46 cohorts, 36 092 participants); only studies of patients with chronic kidney disease (57%) and the general older‐elderly (median, 68 years; range, 60–80 years) populations (26%) had sufficient data to meta‐analyze. People with any or more advanced AAC had higher risk of cardiovascular events (RR, 1.83; 95% CI, 1.40–2.39), fatal cardiovascular events (RR, 1.85; 95% CI, 1.44–2.39), and all‐cause mortality (RR, 1.98; 95% CI, 1.55–2.53). Patients with chronic kidney disease with any or more advanced AAC had a higher risk of cardiovascular events (RR, 3.47; 95% CI, 2.21–5.45), fatal cardiovascular events (RR, 3.68; 95% CI, 2.32–5.84), and all‐cause mortality (RR, 2.40; 95% CI, 1.95–2.97). Conclusions Higher‐risk populations, such as the elderly and those with chronic kidney disease with AAC have substantially greater risk of future cardiovascular events and poorer prognosis. Providing information on AAC may help clinicians understand and manage patients' cardiovascular risk better.

High Phosphorus Level Leads to Aortic Calcification via β-Catenin in Chronic Kidney Disease

2015 ◽  
Vol 41 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Li Yao ◽  
Yi-ting Sun ◽  
Wei Sun ◽  
Tian-hua Xu ◽  
Chuang Ren ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Levels ◽  
Aortic Calcification ◽  
In Vivo Model ◽  
Phosphorus Level ◽  
Abdominal Aortic Calcification ◽  
High Phosphorus ◽  
Abdominal Aortic

Aims: Vascular calcification is a risk factor for causing cardiovascular events and has a high prevalence among chronic kidney disease (CKD) patients. However, the molecular mechanism underlying this pathogenic process is still obscure. Methods: Vascular smooth muscle cells (VSMCs) were induced by a concentration of phosphorus (Pi) of 2.5 mM, and were subjected to cell calcification analyses. The effect of high Pi on the Wnt/β-catenin pathway was measured using a TOP/FOP-Flash reporter assay. The transcriptional regulation of β-catenin on PIT1 (a type III sodium-dependent phosphate cotransporter) was confirmed by promoter reporter and chromatin immunoprecipitation assays. The 5/6 nephrectomized rat was used as an in vivo model and was fed a high Pi diet to induce aortic calcification. Serum levels of phosphate, calcium, creatine, and blood urea nitrogen were measured, and abdominal aortic calcification was examined. Results: High Pi induced VSMC calcification, downregulated expression levels of VSMC markers, and upregulated levels of osteogenic markers. High Pi activated the Wnt/β-catenin pathway and β-catenin activity. β-Catenin was involved in the process of high Pi-induced VSMC calcification. Further investigation revealed that β-catenin transcriptionally regulated Pit1, a necessary player in VSMC osteogenic phenotype change and calcification. The in vivo study showed that β-catenin was involved in rat abdominal aortic calcification induced by high Pi. When knockdown expression of β-catenin in the rat model was investigated, we found that aortic calcification was reduced. Conclusion: These results suggest that β-catenin is an important player in high phosphorus level-induced aortic calcification in CKD.

Association between AST-120 and abdominal aortic calcification in predialysis patients with chronic kidney disease

2012 ◽  
Vol 17 (3) ◽  
pp. 365-371 ◽  
Author(s):  
Shunsuke Goto ◽  
Ken Kitamura ◽  
Keiji Kono ◽  
Kentaro Nakai ◽  
Hideki Fujii ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

P0756THE RELATIONSHIP BETWEEN ABDOMINAL AORTIC CALCIFICATION AND PROGRESSION OF RENAL INSUFFICIENCY IN PATIENTS WITH CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
SO MI KIM ◽  
Jong Tae Cho ◽  
Ji Hyun Jeon ◽  
Yong-Moon Lee ◽  
Eun Kyoung Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Insufficiency ◽  
Early Stage ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
The Impact ◽  
Annual Decline

Abstract Background and Aims Although abdominal aortic calcification (AAC) is known to be associated with cardiovascular mortality in patients with chronic kidney disease (CKD), there are little information about the impact of AAC on progression of CKD. Therefore, we investigated the relationship between the AAC and progression of renal insufficiency in CKD patients with early stage. Method A total of 183 patients with CKD, stage 3 was included. The degree of AAC was evaluated by computed tomography and the score was calculated as follows: abdominal calcification index (ACI)= (total score of calcification on all slices)/12 × 1/(number of slices) × 100%. Based on tertile of ACI, the patients were divided into three groups: low-, intermediate-, and high-groups. The annual decline of glomerular filtration rate (GFR) and time to dialysis were assessed. Results The AAC was found (ACI > 0) in 129 patients (70.4%), and the mean ACI was 21.3 %. The average duration of follow-up was 46.9 months. The high ACI group showed higher annual decline in GFR compared to other groups (27.8 vs 14.5 vs 11.3 mL/min, p=0.042). During the follow-up, 68.8% (42/61) of high ACI group received dialysis and the time to dialysis was significantly shorter than other groups (14.8 vs. 25.8 vs.29.1 months, p=0.038) Conclusion In this study, we showed the AAC was associated with rapid progression of CKD. Evaluation of the AAC in CKD with early stage provides useful information for predicting the progression of CKD.

Impact of abdominal aortic calcification on long-term cardiovascular outcomes in patients with chronic kidney disease

2015 ◽  
Vol 243 (2) ◽  
pp. 349-355 ◽  
Author(s):  
Yosuke Tatami ◽  
Yoshinari Yasuda ◽  
Susumu Suzuki ◽  
Hideki Ishii ◽  
Akihiro Sawai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular Outcomes ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

Protective Effect of Myo-Inositol Hexaphosphate (Phytate) on Abdominal Aortic Calcification in Patients With Chronic Kidney Disease

2016 ◽  
Vol 26 (4) ◽  
pp. 226-236 ◽  
Author(s):  
Pilar Sanchis ◽  
Juan Manuel Buades ◽  
Francisco Berga ◽  
Miguel Mas Gelabert ◽  
Marilisa Molina ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protective Effect ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Inositol Hexaphosphate ◽  
Abdominal Aortic

scholarly journals Maximal Stress Ergometry Performance is Associated with Troponin T and Abdominal Aortic Calcification Score in Severe Chronic Kidney Disease

2020 ◽  
Author(s):  
Roosa Lankinen ◽  
Markus Hakamäki ◽  
Kaj Metsärinne ◽  
Niina S Koivuviita ◽  
Jussi P Pärkkä ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Troponin T ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Aortic Calcification ◽  
Cardiac Biomarkers ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
Calcification Score

Abstract Background Cardiac biomarkers Troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (proBNP) and abdominal aortic calcification score (AAC) are associated with cardiovascular events and mortality in patients with chronic kidney disease (CKD). The effects of cardiac biomarkers and AAC on maximal exercise capacity in CKD are unknown and were studied. Methods 174 CKD 4-5 patients not on maintenance dialysis underwent maximal bicycle ergometry stress testing, lateral lumbar radiograph to study AAC, echocardiography and biochemical assessments. Results The subjects with proportional maximal ergometry workload (WMAX%) less than 50% of the expected values had higher TnT, proBNP, AAC, left ventricular end-diastolic diameter, left ventricular mass index, E/e’ and pulse pressure, and lower global longitudinal strain compared to the better performing patients. TnT (β= -0.09, p=0.02), AAC (β= -1.67, p<0.0001) and diabetes (β= -11.07, p<0.0001) remained significantly associated with WMAX% in the multivariable model. Maximal ergometry workload (in Watts) was similarly associated with TnT and AAC in addition to age, male gender, hemoglobin and diastolic blood pressure in a respective multivariate model. AAC and TnT showed fair predictive power for WMAX% less than 50% of the expected value with AUCs of 0.70 and 0.75, respectivelyConclusions TnT and AAC are independent determinants of maximal ergometry stress test workload in patients with advanced CKD.http://www.ClinicalTrials.gov NCT04223726

scholarly journals Prevalence of and Predictive Factor for Abdominal Aortic Calcification in Thai Chronic Kidney Disease Patients

2017 ◽  
Vol 21 (6) ◽  
pp. 611-619 ◽  
Author(s):  
Dusit Lumlertgul ◽  
Surasak Kantachuvesiri ◽  
Somboon Apichaiyingyurd ◽  
Worapot Treamtrakanpon ◽  
Manoch Rattanasompattikul ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Predictive Factor ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic

Assessment of abdominal aortic calcification at different stages of chronic kidney disease

2016 ◽  
Vol 48 (12) ◽  
pp. 2061-2068 ◽  
Author(s):  
Zeynep Biyik ◽  
Nedim Yilmaz Selcuk ◽  
Halil Zeki Tonbul ◽  
Melih Anil ◽  
Mehmet Uyar
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aortic Calcification ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic
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