A survey on the impact of the COVID‐19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase

Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygenases. While activation of HIF protects from ischemic cell death, HIF has been shown to promote fibrosis in experimental models of CKD. The impact of HIF activation on AKI-induced fibrosis has not been defined. Here, we investigated the role of pharmacologic HIF activation in AKI-associated fibrosis and inflammation. We found that pharmacologic inhibition of HIF prolyl hydroxylation before AKI ameliorated fibrosis and prevented anemia, while inhibition of HIF prolyl hydroxylation in the early recovery phase of AKI did not affect short- or long-term clinical outcome. Therefore, preischemic targeting of the PHD/HIF pathway represents an effective therapeutic strategy for the prevention of CKD resulting from AKI, and it warrants further investigation in clinical trials.

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Exercise electrocardiography for diagnosis of coronary artery disease: impact of sampling rate on the diagnostic performance of ST/HR-loop based on data from early recovery phase

Clinical Physiology and Functional Imaging ◽

10.1111/j.1475-097x.2007.00780.x ◽

2008 ◽

Vol 28 (2) ◽

pp. 96-100 ◽

Cited By ~ 1

Author(s):

Håkan Kronander ◽

Werner Fischer-Colbrie ◽

Jacek Nowak ◽

Lars-Åke Brodin ◽

Håkan Elmqvist

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diagnostic Performance ◽

Sampling Rate ◽

Recovery Phase ◽

Early Recovery ◽

Exercise Electrocardiography ◽

Disease Impact ◽

Artery Disease ◽

Early Recovery Phase

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The role of precipitation losses in producing the rapid early recovery phase of the Great Magnetic Storm of February 1986

Journal of Geophysical Research Atmospheres ◽

10.1029/97ja03330 ◽

1998 ◽

Vol 103 (A4) ◽

pp. 6801-6814 ◽

Cited By ~ 70

Author(s):

J. U. Kozyra ◽

M.-C. Fok ◽

E. R. Sanchez ◽

D. S. Evans ◽

D. C. Hamilton ◽

...

Keyword(s):

Magnetic Storm ◽

Recovery Phase ◽

Early Recovery ◽

Early Recovery Phase

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Relationship Between Survivors' Perceived Health Status Following Acute Coronary Syndrome and Depression Symptoms During Early Recovery Phase

Asian Nursing Research ◽

10.1016/s1976-1317(11)60002-9 ◽

2010 ◽

Vol 4 (4) ◽

pp. 174-184 ◽

Cited By ~ 1

Author(s):

Nah-Mee Shin ◽

JiWon Choi

Keyword(s):

Acute Coronary Syndrome ◽

Health Status ◽

Perceived Health ◽

Recovery Phase ◽

Depression Symptoms ◽

Perceived Health Status ◽

Early Recovery ◽

Coronary Syndrome ◽

Early Recovery Phase

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Abstract 17270: Prognostic Impact of Ventricular Ectopy During the Recovery Phase of Stress Testing: A Meta-Analysis

Circulation ◽

10.1161/circ.138.suppl_1.17270 ◽

2018 ◽

Vol 138 (Suppl_1) ◽

Author(s):

Muhammad T Ayub ◽

Muhammad S Khan ◽

Sagar Ranka ◽

Muhammad Ishaq ◽

Muhammad F Khalid ◽

...

Keyword(s):

Stress Testing ◽

Meta Analysis ◽

Recovery Phase ◽

Prognostic Impact ◽

Ventricular Ectopy ◽

Early Recovery ◽

Premature Ventricular Contractions ◽

Risk Of Death ◽

All Cause Mortality ◽

Early Recovery Phase

Introduction: Ventricular ectopy after exercise, due to parasympathetic activity, predicts an increased risk of death in population-based cohorts. We sought to examine the composite risk of all cause mortality in patients with premature ventricular contractions (PVCs) in the early recovery phase of stress testing. Methods: PubMed, Medline & EMBASE were queried for all English language articles from 1993 to 2017. The primary outcome was incidence of all cause mortality in patients with frequent PVCs during recovery phase (RPV) of stress testing. Frequent PVCs were defined as the presence of seven or more ventricular premature beats/min, frequent ventricular couplets, ventricular bigeminy or trigeminy, or any other form of ventricular tachycardia or ventricular fibrillation. Meta-analysis of the main outcome was performed using a weighted random effects model. Results: A total of four observational studies including 38765 patients were retrieved. Data for 2065 patients with RPV was pooled. A comparative analysis of PVC vs Infrequent/Non-PVC group showed a calculated risk ratio for all cause mortality of 1.8 (95% CI 1.36-2.38; p=0.001). I 2 statistic for heterogeneity testing was 82.8% (Fig.1). Conclusion: Frequent premature ventricular contractions during early recovery phase of stress testing are associated with increased all cause mortality as compared to patients with infrequent or no PVCs.

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Abstract 2142: Diagnostic and Prognostic Value of Augmented ST-Segment Elevation at Exercise Testing in Patients with Brugada Syndrome

Circulation ◽

10.1161/circ.118.suppl_18.s_674-b ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Hisaki Makimoto ◽

Eiichiro Nakagawa ◽

Hiroshi Takaki ◽

Kenichiro Yamagata ◽

Hiro Kawata ◽

...

Keyword(s):

Exercise Testing ◽

Brugada Syndrome ◽

Recovery Phase ◽

Peak Exercise ◽

Early Recovery ◽

St Segment Elevation ◽

St Segment ◽

History Of ◽

Diagnostic And Prognostic Value ◽

Early Recovery Phase

Background : It has been reported that ST-segment elevation was augmented at early recovery phase or at peak exercise during exercise testing in some patients with Brugada syndrome (BrS), but its diagnostic and prognostic value has not fully been clarified. Methods : Treadmill exercise testing (TMT) was conducted in 93 patients (pts) with BrS (22 documented VF, 31 syncope alone, and 40 asymptomatic; 91 males, 46±14 years) and 22 healthy control subjects (20 males, 48±14 years, 11 with incomplete right bundle branch block (RBBB) and 4 with complete RBBB). Results : The augmentation of ST-segment elevation ≥0.05mV in V1-V3 leads compared with that before exercise was observed at early recovery phase (1– 4 minutes at recovery phase) in 32 BrS pts (34%, Group1), at peak exercise in 8 BrS pts (9%, Group 2), but not in either the remaining 53 BrS pts (57%, Group 3) or 22 control subjects. There were no significant differences among the 3 BrS groups in the baseline clinical (age, gender, family history of sudden death, SCN5A mutation), electrocardiographic (PR, QRS duration, QTc interval and ST amplitude), and electrophysiologic (AH, HV interval, and VF induction) variables except for the positive ratio of signal averaged ECG (87%, 48%, 63%; P= 0.001). No significant difference was observed in the proportion of previous cardiac events (VF/syncope/asymptomatic; 6/12/14, 0/3/5, 16/16/21, respectively for Group 1, 2, and 3). During 76.0, 74.8, and 52.0 months follow-up, VF occurred in 12/32 (38%) pts of Group1, 0/8 (0 %) pts of Group2, and 10/53 (19%) pts of Group3. Augmentation of ST-segment elevation at early recovery phase was a significant and an independent predictor for subsequent VF occurrence (12/32 (38%) in Group1 vs. 10/61 (16%) in Group2 and 3; hazard ratio [HR]= 1.68; P=0.014), especially in 31 pts with a history of syncope alone (6/12 (50%) in Group1 vs. 1/19 (5%) in Group2 and 3; HR=3.44; P=0.004). Conclusions : Our data suggest that augmentation of ST-segment elevation at early recovery phase during exercise testing can be a predictor of poor prognosis in patients with Brugada syndrome, especially in those with a history of syncope alone.

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