Does autoimmune thyroid disorder act as a predisposing factor in the development of oral lichen planus?

Oral Diseases ◽  
2020 ◽  
Vol 26 (6) ◽  
pp. 1337-1339
Author(s):  
Silvio Hirota ◽  
Suemi Marui ◽  
Dante Migliari
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Thyroid Disorder ◽  
Predisposing Factor ◽  
Autoimmune Thyroid ◽  
Autoimmune Thyroid Disorder ◽  
Oral Lichen

scholarly journals Prevalence of Common Candida Species in Oral Lichen Planus Patients: A Cross-Sectional Study in South of Iran

2014 ◽  
Vol 3 (4) ◽  
pp. 252-5
Author(s):  
Hooman Ebrahimi ◽  
Keyvan Pakshir ◽  
Sara Pourshahidi ◽  
Kamyar Zomorodian ◽  
Maryam Saki ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Candidiasis ◽  
Cross Sectional Study ◽  
Fungal Species ◽  
Unknown Etiology ◽  
Predisposing Factor ◽  
Cross Sectional ◽  
Colony Color ◽  
Oral Lichen

Background: Lichen Planus is a common mucocutaneous disease with unknown etiology. Immunodeficiency is a known predisposing factor to this disease. Oral Candidiasis which is an opportunistic fungal infection, commonly affects healthy and immune-compromised patients. Candida has different species bearing different treatments. In this study, researchers aimed to detect the frequency and colonization rate of Candida and its association with different factors such as lesion types of oral lichen Planus (OLP).Materials and Methods: Thirty seven untreated oral lichen Planus patients, attending the Clinical Department of Oral Medicine at Shiraz Dental School in 2011, were selected. Swab method and CHROMagar media were used to obtain samples incubated for 48 hours at 30 ºC. Fungal species were detected considering colony color changes.Results: In the culture test, approximately 80% of samples were positive of non-reticular type. About 40% of positive samples were of Candida non-albicans (C.Non-albicans) type. Among C. Non-albicans, 85% were non-reticular type among OLP patients. There was no significant statistical difference in prevalence of Candida albicans (C.albicans) and C. Non-albicans in OLP patients.Conclusion: Based on results, certain biotypes of Candida were not confirmed responsible for OLP patterns.[GMJ.2014;3(4):252-5]

A mechanistic linkage between oral lichen planus and autoimmune thyroid disease

Oral Diseases ◽  
2018 ◽  
Vol 24 (6) ◽  
pp. 1001-1011 ◽  
Author(s):  
J Robledo-Sierra ◽  
K Landin-Wilhelmsen ◽  
H Filipsson Nyström ◽  
R Eggertsen ◽  
L Larsson ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Oral Lichen Planus ◽  
Autoimmune Thyroid ◽  
Oral Lichen

scholarly journals Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

2017 ◽  
Vol 6 (8) ◽  
pp. 726-730 ◽  
Author(s):  
Paolo G Arduino ◽  
Dora Karimi ◽  
Federico Tirone ◽  
Veronica Sciannameo ◽  
Fulvio Ricceri ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Smoking Status ◽  
Oral Lesions ◽  
Thyroid Disorder ◽  
Newly Diagnosed ◽  
Hepatitis C Infection ◽  
Control Approach ◽  
Potentially Malignant ◽  
Oral Lichen

The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Patients suffering from thyroid diseases were associated with an almost 3-fold increased odds of having OLP (OR 2.85, 95% CI: 1.65–4.94), after adjusting this analysis for age, gender, body mass index, smoking status, diabetes, hypertension and hepatitis C infection. It would be appropriate to further investigate the possible concomitance of OLP among patients with thyroid disorder; endocrinologists should be aware of this association, especially because OLP is considered a potentially malignant oral disorder.

scholarly journals Evaluation of polymorphism of P53 protein codon 72 in oral lichen planus by PCR technique

2018 ◽  
Vol 12 (4) ◽  
pp. 245-251 ◽  
Author(s):  
Seyed Hosein Tabatabaei ◽  
Mohammad Hasan Sheikhha ◽  
Mahammad Hasan Akhavan Karbasi ◽  
sedighe zarmehi ◽  
Mehdi Hoseini
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
P53 Protein ◽  
Positive Control ◽  
Negative Control ◽  
Predisposing Factor ◽  
Tissue Samples ◽  
Codon 72 ◽  
Chi Squared ◽  
Oral Lichen

Background. Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Methods. Seventy paraffin-embedded tissue samples (30 OLP, 20 OSCC and 20 IFH) were studied. DNA was purified and amplified using allele-specific polymerase chain reaction to detect polymorphism. The final amplified products were identified using gel electrophoresis. Data were analyzed using chi-squared test and odds ratio. Results. The mean ages in the OLP, OSCC and IFH groups were 43.28, 58.2 and 53.47 years, respectively, with significant differences. There were no significant differences in gender between the three groups (P=0.413); however, the differences in genotypes and alleles were significant between the three groups (P=0.021 and P=0.030, respectively). By considering IFH as a reference, the frequency of proline allele in OLP and OSCC was significantly higher than that of arginine allele (P=0.015 and P=0.028, respectively). In addition, by considering OSCC as a reference and at P=1, there were no significant differences in the frequencies of alleles between OSCC and OLP. Conclusion. The results might indicate the premalignant potential of OLP, and such polymorphism might be a genetic predisposing factor for conversion of OLP to OSCC. In addition, in the subjects evaluated the proline allele was considered a risk factor.

scholarly journals A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus

2012 ◽  
Vol 3 (4) ◽  
pp. 330-334 ◽  
Author(s):  
Rubina Anjum ◽  
Jasmin Singh ◽  
Shailesh Kudva
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodic Acid ◽  
Inflammatory Cells ◽  
Probable Mechanism ◽  
Stool Examination ◽  
Gamma Aminobutyric Acid ◽  
Predisposing Factor ◽  
Cross Sectional ◽  
Oral Lichen

ABSTRACT Aim Probable mechanism of pigmentation in oral lichen planus which is associated with anxiety disorder and its relation to gamma aminobutyric acid whose imbalance in brain occurs during stress and strain. Materials and methods A cross-sectional study comprising of 33 cases of clinically diagnosed oral lichen planus was conducted. Ethical clearance and informed consent was obtained. Detailed history was recorded and clinical examination was conducted. All patients were subjected to thorough routine blood, urine and stool examination for any systemic conditions. Clinical photographs and biopsies were obtained. The biopsy specimens were subjected to hematoxylin and eosin and periodic acid Schiff's reagent staining. Results Histopathological features of lichen planus include hyperkeratosis, liquefaction degeneration of stratum basale and subepithelial band of chronic inflammatory cells. Lichen planus is related to anxiety as predisposing factor. Conclusion Due to excitation of melanocytes lichen planus are seen with pigmentation. How to cite this article Anjum R, Singh J, Kudva S. A Clinicohistopathologic Study and Probable Mechanism of Pigmentation in Oral Lichen Planus. World J Dent 2012;3(4):330-334.

scholarly journals Oral Lichen Planus in Thai Patients Has a Low Prevalence of Human Papillomavirus

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Pratanporn Arirachakaran ◽  
Jira Chansaengroj ◽  
Woradee Lurchachaiwong ◽  
Patnarin Kanjanabud ◽  
Kobkan Thongprasom ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Cell Function ◽  
Hpv Infection ◽  
Predisposing Factor ◽  
Hpv Dna ◽  
Tissue Biopsy ◽  
Low Prevalence ◽  
Oral Lichen

Background. Oral lichen planus (OLP) is a common chronic inflammatory immune-mediated disease, with an etiopathogenesis associated with cell-mediated immunological dysfunction. Viral infection has been hypothesized as a predisposing factor in the pathogenesis of this disease. Viruses may alter host cell function by inducing the abnormal expression of cellular proteins leading to disease development. However, reports on the relationship between human papillomavirus (HPV) and OLP are inconclusive. Objective. To explore the association between HPV and OLP in Thai patients. Materials and Methods. DNA was extracted from thirty-seven fresh-frozen tissue biopsy specimens from OLP lesions, and polymerase chain reaction assay for the L1 and E1 genes covering 32 types of high- and low-risk HPV was performed. Results. HPV DNA was detected in one tissue biopsy from an atrophic-type OLP lesion. All control samples were negative. Genomic sequencing of the E1 gene PCR product demonstrated that the HPV-type 16 found in the lesion is closely related to the East Asian type. Conclusion. Our data indicate a low prevalence of HPV infection in OLP lesions in Thai patients.

scholarly journals Pigmented Oral Lichen Planus: A Case Report

2017 ◽  
Vol 1 (1) ◽  
pp. 11
Author(s):  
Firstine Kelsi Hartanto ◽  
Thomas George Kallarakal
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Diagnostic Process ◽  
Clinical Feature ◽  
Inflammatory Disorder ◽  
Predisposing Factor ◽  
Oral Lichen

<p><strong>Background:</strong> Lichen planus is a chronic muccocutaneous inflammatory disorder. Oral lichen planus (OLP) has certain specific characteristics in its clinical presentation, but can also be presented in forms resembling other diseases. This may introduce difficulty in the diagnostic process. It has been reported that OLP affects between 0.1 to 4% individuals, predominantly women and people over 40 years old. <strong>Case Report:</strong> A 46-year-old woman complained of a non-healing ulcer present for 1.5 months. Intraorally, multiple white striae with prominent central areas of brownish hyperpigmentation were apparent on the right and left buccal mucosa, right and left buccal sulcus, and lateral and dorsum of the tongue. A biopsy was completed and the histopathology features confirmed the diagnosis of OLP. For the initial treatment, a topical corticosteroid was prescribed, followed by steroid mouthwash. Response to this treatment was positive. OLP has been frequently reported to affect women over the age of 40, with psychological stress as a primary predisposing factor. The clinical presentation is characteristic of Wickham’s striae with erosive areas. However, a biopsy and histopathological examination is mandatory to confirm the diagnosis. The clinical feature of pigmented OLP has been reported and confirmed by microscopic finding of band-like lymphocytic appearance which is the pathognomonic features of OLP, along with basal cell liquefaction degeneration, and melanin in continence at the lamina propria. <strong>Conclusion:</strong> Pigmented OLP is a variant of erosive OLP. Anamnesis, clinical presentation, and histopathological examination confirm diagnosis.</p>

Vitamin A acid in treatment of oral lichen planus

1973 ◽  
Vol 107 (2) ◽  
pp. 277-277 ◽  
Author(s):  
S. H. Gunther
Keyword(s):  
Vitamin A ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Vitamin A Acid ◽  
Oral Lichen

Suspect Oral Lichen Planus? Be Aware of Imitators

2006 ◽  
Vol 37 (10) ◽  
pp. 34
Author(s):  
ROBERT FINN
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

Oral Lichen Planus in Childhood

2006 ◽  
Vol 2006 ◽  
pp. 98-99
Author(s):  
S. Raimer
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen
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