scholarly journals Aneuploidy and loss of heterozygosity as risk markers for malignant transformation in oral mucosa

Oral Diseases ◽  
2021 ◽  
Author(s):  
Edward W. Odell
Keyword(s):  
Malignant Transformation ◽  
Loss Of Heterozygosity ◽  
Oral Mucosa ◽  
Risk Markers

scholarly journals Podoplanin and ABCG2: Malignant Transformation Risk Markers for Oral Lichen Planus

2010 ◽  
Vol 19 (3) ◽  
pp. 844-849 ◽  
Author(s):  
Peng Shi ◽  
Wei Liu ◽  
Zeng-Tong Zhou ◽  
Qing-Bo He ◽  
Wei-Wen Jiang
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Risk Markers ◽  
Oral Lichen

Loss of Heterozygosity 1p36 and 19q13 Is a Prognostic Factor for Overall Survival in Patients With Diffuse WHO Grade 2 Gliomas Treated Without Chemotherapy

2006 ◽  
Vol 24 (29) ◽  
pp. 4758-4763 ◽  
Author(s):  
Luigi Mariani ◽  
Gianluca Deiana ◽  
Erik Vassella ◽  
Ali-Reza Fathi ◽  
Christine Murtin ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factor ◽  
Malignant Transformation ◽  
Loss Of Heterozygosity ◽  
Progression Free Survival ◽  
Who Grade ◽  
Free Survival ◽  
Extent Of Surgery ◽  
Oligodendroglial Component ◽  
The Impact

Purpose This study was conducted to elucidate the impact of loss of heterozygosity (LOH) for chromosomes 1p36 and 19q13 on the overall survival of patients with diffusely infiltrating WHO grade 2 gliomas treated without chemotherapy. Patients and Methods We assessed the LOH status of tumors from patients harboring WHO grade 2 gliomas diagnosed between 1991 and 2000. Patients were either followed after initial biopsy or treated by surgery and/or radiation therapy (RT). Overall survival, time to malignant transformation, and progression-free survival were last updated as of March 2005. Results Of a total of 79 patients, LOH 1p36 and LOH 19q13 could be assessed in 67 and 66 patients, respectively. The median follow-up after diagnosis was 6 years. Loss of either 1p or 19q, in particular codeletion(s) at both loci, was found to positively impact on both overall survival (log-rank P < .01), progression-free survival, and survival without malignant transformation (P < .05). Tumor volume (P < .0001), neurologic deficits at diagnosis (P < .01), involvement of more than one lobe (P < .01), and absence of an oligodendroglial component (P < .05) were also predictors of shorter overall survival. The extent of surgery was similar in patients with or without LOH 1p and/or 19q; RT was more frequently resorted to for patients without than for patients with LOH 1p/19q (30% v 60%). Conclusion The presence of LOH on either 1p36 or 19q13, and in particular codeletion of both loci is a strong, nontreatment-related, prognostic factor for overall survival in patients with diffusely infiltrating WHO grade 2 gliomas.

scholarly journals Leucoplasia: revisão de literatura e apresentação de caso clínico

2021 ◽  
Vol 35 (2) ◽  
pp. 20-22
Author(s):  
João Jorge Diniz Barbachan ◽  
Pantelis Varvaki Rados ◽  
Manoel Sant'Ana Fllho ◽  
Manoela Gallicchio Domingues
Keyword(s):  
Literature Review ◽  
Malignant Transformation ◽  
Oral Mucosa ◽  
Clinical Case ◽  
Premalignant Lesions ◽  
Early Diagnose

Leucoplakia is a clinica' term that refers to an alteration on the oral mucosa with the appearance of white patchers that are firmly adhered and cannot be classified as any other diagnosable discase. They are considered premalignant lesions due to the increase in the risk of malignant transformation. In this case, around 4% to 6% of the lesions evolve to cancer. Then, it is necessary to estabilish a correct and early diagnose and also a precise treatment to reach good results. The periodical control of the patients that show this kind of alteration is extremely important. The aim of this study is to discuss the possible ethiological agents, clinical and histopathological aspects as well as, the treatment and prognoses through literature review, illustrating with a clinical case.

Ubiquitin and malignant transformation of oral mucosa

Head & Neck ◽  
2001 ◽  
Vol 23 (11) ◽  
pp. 972-978 ◽  
Author(s):  
Leo H. H. Cheng
Keyword(s):  
Malignant Transformation ◽  
Oral Mucosa

Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis

2011 ◽  
Vol 120 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Bing Xu ◽  
Shinshichi Hamada ◽  
Izumi Kusuki ◽  
Ryoji Itoh ◽  
Jo Kitawaki
Keyword(s):  
Malignant Transformation ◽  
Loss Of Heterozygosity ◽  
Ovarian Endometriosis

scholarly journals Blockade of PD-1 effectively inhibits in vivo malignant transformation of oral mucosa

2017 ◽  
Vol 7 (2) ◽  
pp. e1388484 ◽  
Author(s):  
Yichen Chen ◽  
Qiusheng Li ◽  
Xinye Li ◽  
Da Ma ◽  
Juan Fang ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Mucosa

scholarly journals Oral malignant melanoma: History of malignant degeneration of a pigmented lesion

2019 ◽  
Vol 25 (2) ◽  
pp. 19 ◽  
Author(s):  
Nour Mellouli ◽  
Samah Sioud ◽  
Maroua Garma ◽  
Abdellatif Chokri ◽  
Habib Hamdi ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Transformation ◽  
Oral Mucosa ◽  
Malignant Lesion ◽  
Final Diagnosis ◽  
Malignant Degeneration ◽  
Close Monitoring ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma

Introduction: Oral malignant melanoma (OMM) is a rare malignant lesion of the oral mucosa. It accounts for 0.5% of oral cavity cancers and less than 1% of all melanomas. Most cases arise on the palate or gingiva. OMM is caused by unknown factors. Benign pigmentation may precede the neoplasm by several years. The malignant transformation of benign melanosis is poorly understood. Observation: The aim of this work is to present a new clinical case of oral malignant melanoma which appeared on benign melanosis with a brief review of the literature. A 37-year-old woman presented with a blackish pigmented plaque that covered the hard palate and vestibular maxillary gingiva and a soft, friable 2 cm nodule with ulcerated surface next to the 11, 12 and 13. Fifteen years ago, the patient underwent a biopsy that was in favor of benign melanosis. Unfortunately, the patient was followed for one year and then was lost. Recently, in front of the rapidity of the extension of the lesion, she came again. After biopsy, a final diagnosis of OMM is retained. Commentaries: OMM is often asymptomatic. It presents usually as a 1.5–4 cm, blackish grey, irregular, flat or nodular lesion. The neoplasm can appear on apparently normal oral mucosa and may be preceded by benign pigmented lesions. Few articles discussed malignant transformation of benign melanosis. OMM is characterized by its poor prognosis. The treatment of choice for OMM remains surgery with wide clear margins. Conclusion: Close monitoring is needed to detect signs of transformation and to early diagnose melanoma.

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