A three‐long non‐coding RNA signature that predicts tongue squamous cell carcinoma prognosis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Ran Li ◽  
Fanglong Li ◽  
Yaozhong Wang ◽  
Pugen An ◽  
Yifan Hu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature

scholarly journals A novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 2311-2325
Author(s):  
Lin Chen ◽  
Zhimou Cai ◽  
Kexing Lyu ◽  
Zhiwei Cai ◽  
Wenbin Lei
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognosis Prediction ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature

Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma

Tumor Biology ◽  
2015 ◽  
Vol 36 (11) ◽  
pp. 8805-8809 ◽  
Author(s):  
Hua Zhang ◽  
Lei Zhao ◽  
Ying-Xue Wang ◽  
Mian Xi ◽  
Shi-Liang Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tongue Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma

2018 ◽  
Vol 149 (1) ◽  
pp. 181-187 ◽  
Author(s):  
Xiaogang Mao ◽  
Xiaomin Qin ◽  
Lin Li ◽  
Jinting Zhou ◽  
Min Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Prognosis Prediction ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature

scholarly journals Long non-coding RNA CRNDE promote the progression of tongue squamous cell carcinoma through regulating the PI3K/AKT/mTOR signaling pathway

RSC Advances ◽  
2019 ◽  
Vol 9 (37) ◽  
pp. 21381-21390
Author(s):  
Zhongheng Yang ◽  
Weizhi Chen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Colorectal Neoplasia ◽  
Tongue Squamous Cell Carcinoma ◽  
Mtor Signaling Pathway ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Long Non Coding Rna

Long non-coding RNAs (lnRNAs) colorectal neoplasia differentially expressed (CRNDE) has been identified as a crucial regulator involved in tongue squamous cell carcinoma (TSCC).

Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail

2020 ◽  
Vol 168 (6) ◽  
pp. 651-657 ◽  
Author(s):  
Fenqian Yuan ◽  
Zhiguo Miao ◽  
Wen Chen ◽  
Fanggeng Wu ◽  
Chao Wei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Biology ◽  
Tongue Squamous Cell Carcinoma ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Long non-coding RNA is an endogenous non-coding RNA that has currently been proved to be an important player in cancer cell biology. In the present study, we investigated the biological role of PHACTR2-AS1 in tongue squamous cell carcinoma (TSCC). PHACTR2-AS1 was preferentially localized in the cytoplasm, and was notably upregulated in TSCC tissues. High PHACTR2-AS1 was correlated with tumour differentiation, metastatic clinical features, relapse and shortened survival time. Depletion of PHACTR2-AS1 did not affect TSCC cell viability and colony formation ability, whereas substantially inhibited cell migration and invasion in vitro and lung metastasis in vivo. Mechanistically, PHACTR2-AS1 could sponge miR-137 to increase Snail expression, resulting in triggering epithelial–mesenchymal transition process, thereby promoting TSCC cell metastasis. Taken together, our data for the first time elucidate the metastasis-promoting role of PHACTR2-AS1 in TSCC, hinting a new therapeutic target for metastatic TSCC patients.

scholarly journals Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma

2017 ◽  
Vol 8 (4) ◽  
pp. 523-530 ◽  
Author(s):  
Jianjun Yu ◽  
Yan Liu ◽  
Can Guo ◽  
Shanshan Zhang ◽  
Zhaojian Gong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long Non-Coding RNA Deregulation in Tongue Squamous Cell Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Wei Gao ◽  
Jimmy Yu-Wai Chan ◽  
Thian-Sze Wong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Expression Patterns ◽  
Tongue Squamous Cell Carcinoma ◽  
Expression Array ◽  
Real Time Quantitative Pcr ◽  
T Stage ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Background.The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC).Methods.Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to validate the identified lncRNAs.Results.Using the functional annotation algorithm from ncFANs, 8 differentially expressed lncRNAs were identified. Lnc-PPP2R4-5, lnc-SPRR2D-1, lnc-MAN1A2-1, lnc-FAM46A-1, lnc-MBL2-4:1, and lnc-MBL2-4:3 were upregulated in the microdissected tongue SCC tissues. In comparison, lnc-AL355149.1-1 and lnc-STXBP5-1 showed significant downregulation. High level of lnc-MBL2-4:3 was significantly associated with the node positive tongue SCC patients. Further, patients with advanced T-stage demonstrated a further reduction of lnc-AL355149.1-1 in the tumor tissues. Treatment of tongue SCC cells with 5-fluorouracil and paclitaxel can reserve the expression patterns observed in the tongue SCC tissues. Further, changes of lnc-MBL2-4:3 and lnc-AL355149.1-1 expression levels were noticed in the cisplatin-resistant tongue SCC cells.Conclusions.Our results demonstrated that functional reannotation allows us to identify novel lncRNAs using the existing gene expression array dataset. The association of lncRNA with the T-stage and nodal status of tongue SCC patients suggested that lncRNA deregulation was involved in the pathogenesis of tongue SCC.

scholarly journals A Novel Autophagy-Related Long Non-Coding RNA Signature to Predict Prognosis and Therapeutic Response in Esophageal Squamous Cell Carcinoma

2021 ◽  
Vol Volume 14 ◽  
pp. 8325-8339
Author(s):  
Xiaobo Shi ◽  
Xiaoxiao Liu ◽  
Shupei Pan ◽  
Yue Ke ◽  
Yuxing Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Response ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Signature
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