Role of Triggering Pulmonary Veins in the Maintenance of Sustained Paroxysmal Atrial Fibrillation

2013 ◽  
Vol 36 (7) ◽  
pp. 845-854 ◽  
Author(s):  
VASSIL B. TRAYKOV ◽  
RÓBERT PAP ◽  
ZOLTÁN GINGL ◽  
SZAMI CHADAIDE ◽  
HARIS M. HAQQANI ◽  
...  

Author(s):  
Sapan Bhuta ◽  
Gustaf Sverin ◽  
Hiro Kawata ◽  
Malek Bashti ◽  
Jessica Hunter ◽  
...  

Background: Previous studies suggest that wide area circumferential pulmonary vein ablation (WACA) is more effective than segmental pulmonary vein ablation (SPVA) for pulmonary vein isolation (PVI) for treatment of atrial fibrillation. Whether this is true in patients (pts) with very short duration paroxysmal atrial fibrillation (PAF) is unknown. Objective: To compare WACA to SPVA in pts with PAF lasting <48 hours. Methods: One hundred pts with PAF <48 hours were randomized to either WACA vs SPVA (45 and 53 pts respectively, with 2 withdrawals), and followed up for 24 months with 14-day ECGs every 6 months. Results: Among 97 pts at an average of 22.1±4.8 months followup, 26 (57.8%) remained free of any atrial arrhythmias after WACA versus 29 (55.86%) after SPVA (p=0.64). Sixteen pts (35.6%) had recurrent PAF after WACA versus 20 pts (38.5%) after SPVA (p=0.79). Seven pts (15.6%) had atrial flutter after WACA versus 5 pts (9.64%) after SPVA (p=0.376) and 1 pt (2.2%) had atrial tachycardia after WACA vs 1 pt (1.9%) after SPVA (p=0.918). Total procedure time was lower for SPVA vs WACA (242.9 vs 271.1 minutes, p= 0.047), and fluoroscopy time similar for WACA vs SPVA (50.8 vs 53.4 minutes, p=0.555). Conclusions: As an initial ablation approach in pts with PAF <48 hours, SPVA was similarly effective to WACA with respect to arrhythmia recurrence, supporting the central role of the pulmonary veins for maintaining AF in these pts. Future therapies using alternative ablation energies may incorporate these insights to reduce risk to gastroesophageal structures.



2010 ◽  
Vol 21 (9) ◽  
pp. 959-965 ◽  
Author(s):  
YONG-HYUN KIM ◽  
HONG EUY LIM ◽  
HUI-NAM PAK ◽  
JAE-JIN KWAK ◽  
JAE-SEOK PARK ◽  
...  


Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2406-PUB
Author(s):  
KONSTANTINA KANELLOPOULOU ◽  
IOANNIS L. MATSOUKIS ◽  
ASIMINA GANOTOPOULOU ◽  
THEODORA ATHANASOPOULOU ◽  
CHRYSOULA TRIANTAFILLOPOULOU ◽  
...  


2021 ◽  
Vol 10 (14) ◽  
pp. 3129
Author(s):  
Riyaz A. Kaba ◽  
Aziz Momin ◽  
John Camm

Atrial fibrillation (AF) is a global disease with rapidly rising incidence and prevalence. It is associated with a higher risk of stroke, dementia, cognitive decline, sudden and cardiovascular death, heart failure and impairment in quality of life. The disease is a major burden on the healthcare system. Paroxysmal AF is typically managed with medications or endocardial catheter ablation to good effect. However, a large proportion of patients with AF have persistent or long-standing persistent AF, which are more complex forms of the condition and thus more difficult to treat. This is in part due to the progressive electro-anatomical changes that occur with AF persistence and the spread of arrhythmogenic triggers and substrates outside of the pulmonary veins. The posterior wall of the left atrium is a common site for these changes and has become a target of ablation strategies to treat these more resistant forms of AF. In this review, we discuss the role of the posterior left atrial wall in persistent and long-standing persistent AF, the limitations of current endocardial-focused treatment strategies, and future perspectives on hybrid epicardial–endocardial approaches to posterior wall isolation or ablation.



2021 ◽  
Vol 77 (18) ◽  
pp. 324
Author(s):  
Abhishek Bose ◽  
Parag Anilkumar Chevli ◽  
Zeba Hashmath ◽  
Ajay K. Mishra ◽  
Gregory Berberian ◽  
...  




EP Europace ◽  
2005 ◽  
Vol 7 (Supplement_1) ◽  
pp. 177-177
Author(s):  
K. Szydlo ◽  
A. Wnuk-Wojnar ◽  
M. Trusz-Gluza ◽  
C. Czerwinski ◽  
I. Wozniak-Skowerska ◽  
...  


2005 ◽  
Vol 16 (1) ◽  
pp. 39-44 ◽  
Author(s):  
THOMAS ROSTOCK ◽  
HELGE SERVATIUS ◽  
TIM RISIUS ◽  
RODOLFO VENTURA ◽  
CHRISTIAN WEISS ◽  
...  


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