The Efficacy of Propofol vs. Subcutaneous Sumatriptan for Treatment of Acute Migraine Headaches in the Emergency Department: A Double-Blinded Clinical Trial

Pain Practice ◽  
2014 ◽  
Vol 15 (8) ◽  
pp. 701-705 ◽  
Author(s):  
Hossein Moshtaghion ◽  
Najmeh Heiranizadeh ◽  
Abolghasem Rahimdel ◽  
Alireza Esmaeili ◽  
Hamidreza Hashemian ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Acute Migraine ◽  
Migraine Headaches ◽  
Subcutaneous Sumatriptan ◽  
Double Blinded

Lidocaine Adrenaline Tetracaine Gel Versus Tetracaine Adrenaline Cocaine Gel for Topical Anesthesia in Linear Scalp and Facial Lacerations in Children Aged 5 to 17 Years

PEDIATRICS ◽  
1995 ◽  
Vol 95 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Amy A Ernst ◽  
Eduardo Marvez ◽  
Todd G. Nick ◽  
Eric Chin ◽  
Edmond Wood ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Inner City ◽  
Rating Scale ◽  
Topical Anesthesia ◽  
Random Numbers ◽  
Study Objective ◽  
The Face ◽  
Double Blinded

Study objective. The purpose of the present study is to compare LAT gel (4% lidocaine, 1:2000 adrenaline, 0.5% tetracaine) to TAC gel (0.5% tetracaine, 1:2000 adrenaline, 11.8% cocaine) for efficacy, side effects, and costs in children aged 5 to 17 years with facial or scalp lacerations. Design. Randomized, prospective, double-blinded clinical trial. Setting. Inner-city Emergency Department with an Emergency Medicine residency program. Patients or other participants. Children aged 5 to 17 years with linear lacerations of the face or scalp. Intervention. After informed consent was obtained patients had lacerations anesthetized with topical TAC or LAT gel according to a random numbers table. Measurements and main results. A total of 95 patients were included in the statistical analysis with 47 receiving TAC and 48 receiving LAT. Physicians and patients/parents separately rated the overall pain of suturing using a modified multidimensional scale for pain assessment specifically for children. Patients/parents also stated the number of sutures causing pain. The power of the study to determine a ranked sum difference of 15 was 0.8. Multidimensional rating scale results and number and percentage of sutures causing pain were compared using Wilcoxon's rank sum test. According to patients no difference could be detected in percent of sutures causing pain in the LAT versus TAC group (P = .51). Using the multidimensional scale, physicians and patients/parents found LAT statistically the same as TAC in effectiveness (P = .80 for physicians and P = .71 for patients). Cost per application was $3.00 for LAT compared to $35.00 for TAC. Follow-up was accomplished in 85 of 95 participants in the study with no reported complications for either medication. Conclusion. LAT gel worked as well as TAC gel for topical anesthesia in facial and scalp lacerations. Considering the advantages of a noncontrolled substance and less expense, LAT gel appears to be better suited than TAC gel for topical anesthesia in laceration repair in children.

The Effectiveness of Combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on Quality of Life of Patients with Migraine Headaches: A Randomized, Double Blinded, Placebo - Controlled Clinical Trial

2019 ◽  
Author(s):  
Mohadese Kamali ◽  
Haleh Tajadini ◽  
Rostam Seifadini ◽  
Mitra Mehrabani ◽  
Yunes Jahani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Coriandrum Sativum ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Rosa Damascena ◽  
Viola Odorata ◽  
Migraine Headaches ◽  
Double Blinded

Headache is one of the most common public health problems in the world, which causes patients to see a doctor. Migraine is the second most common cause of headaches after tension headaches. This study is a randomized, double blinded, placebo - controlled clinical trial, using SF36 questionnaire, to evaluate the effect of combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on the quality of life, in patients with migraine after 4 weeks. In all domains of the SF36 questionnaire, the scores after intervention in the drug group were significantly higher than the control group after 4 weeks. This study showed that, combination of V. odorata, R. damascena and C. sativum, improves the quality of life of patients with migraine.

scholarly journals Diphenhydramine as Adjuvant Therapy for Acute Migraine: An Emergency Department–Based Randomized Clinical Trial

2016 ◽  
Vol 67 (1) ◽  
pp. 32-39.e3 ◽  
Author(s):  
Benjamin W. Friedman ◽  
Lisa Cabral ◽  
Victoria Adewunmi ◽  
Clemencia Solorzano ◽  
David Esses ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Emergency Department ◽  
Adjuvant Therapy ◽  
Randomized Clinical Trial ◽  
Acute Migraine

Self-Treatment of Acute Migraine with Subcutaneous Sumatriptan Using an Auto-Injector Device: Comparison With Customary Treatment in An Open, Longitudinal Study

Cephalalgia ◽  
1994 ◽  
Vol 14 (1) ◽  
pp. 55-63 ◽  
Author(s):  
J Schoenen ◽  
J Bulcke ◽  
J Caekebeke ◽  
I Dehaene ◽  
J De Keyser ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Longitudinal Study ◽  
Treatment Recommendations ◽  
Acute Migraine ◽  
Duration Of Symptoms ◽  
Subcutaneous Sumatriptan ◽  
Auto Injector ◽  
Mild Headache ◽  
At Home

In a multicenter open longitudinal clinical trial where 479 patients suffering from migraine with or without aura were recruited, patients treated at home one to three migraine attacks with their customary treatment, and subsequently, over a 3-month period, one to three migraine attacks with (5 mg sumatriptan sc using an auto-injector. The headache response to customary treatment was 19% at 1 h and 30.5% at 2 h, and was not significantly different when only attacks treated “adequately” according to accepted treatment recommendations were considered: 16% at 1 h and 35% at 2 h. In contrast, 69% and 82% of patients treated with 6 mg sumatriptan sc had mild headache or no headache at 1 and 2 h respectively, regardless of migraine type or duration of symptoms prior to treatment. Other migraine symptoms (nausea, vomiting, photo- and phonophobia) were effectively treated with sumatriptan. Recurrence of migraine was observed in 31% of patients and was well controlled by a second injection of sumatriptan. It is concluded that 6 mg sumatriptan sc, self-administered using an auto-injector, is well tolerated and more effective than most currently used acute treatments for migraine in a population of severely affected patients consulting a neurologist.

Subcutaneous Sumatriptan for Treatment of Acute Migraine in Patients Admitted to the Emergency Department: A Multicenter Study

1995 ◽  
Vol 25 (4) ◽  
pp. 464-469 ◽  
Author(s):  
Basil E Akpunonu ◽  
Anand B Mutgi ◽  
Douglas J Federman ◽  
Fred G Volinsky ◽  
Kris Brickman ◽  
...  
Keyword(s):  
Emergency Department ◽  
Multicenter Study ◽  
Acute Migraine ◽  
Subcutaneous Sumatriptan
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