Maize Sep15 ‐like functions in endoplasmic reticulum and reactive oxygen species homeostasis to promote salt and osmotic stress resistance

2019 ◽  
Vol 42 (5) ◽  
pp. 1486-1502 ◽  
Author(s):  
Jiantang Zhu ◽  
Guangling Wang ◽  
Cuiling Li ◽  
Qingqing Li ◽  
Yankun Gao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Osmotic Stress ◽  
Stress Resistance ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Salt And Osmotic Stress ◽  
Osmotic Stress Resistance

scholarly journals Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells

2021 ◽  
Vol 22 (20) ◽  
pp. 10951
Author(s):  
Chong-Sun Khoi ◽  
Yu-Wen Lin ◽  
Jia-Huang Chen ◽  
Biing-Hui Liu ◽  
Tzu-Yu Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Ochratoxin A ◽  
Reactive Oxygen ◽  
Underlying Mechanism ◽  
Oxygen Species ◽  
Food And Feed ◽  
Renal Proximal Tubular Cells ◽  
Induced Apoptosis

Ochratoxin A (OTA), one of the major food-borne mycotoxins, impacts the health of humans and livestock by contaminating food and feed. However, the underlying mechanism of OTA nephrotoxicity remains unknown. This study demonstrated that OTA induced apoptosis through selective endoplasmic reticulum (ER) stress activation in human renal proximal tubular cells (HK-2). OTA increased ER-stress-related JNK and precursor caspase-4 cleavage apoptotic pathways. Further study revealed that OTA increased reactive oxygen species (ROS) levels, and N-acetyl cysteine (NAC) could reduce OTA-induced JNK-related apoptosis and ROS levels in HK-2 cells. Our results demonstrate that OTA induced ER stress-related apoptosis through an ROS-mediated pathway. This study provides new evidence to clarify the mechanism of OTA-induced nephrotoxicity.

Rosemary extract modulates stress resistance and accumulation of reactive oxygen species in the model organism Caenorhabditis elegans

2020 ◽  
Vol 14 ◽  
pp. 100233
Author(s):  
Christina Saier ◽  
Stephanie Storbeck ◽  
Sabrina Baier ◽  
Heiko Dietz ◽  
Wim Wätjen
Keyword(s):  
Reactive Oxygen Species ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Model Organism ◽  
Reactive Oxygen ◽  
Rosemary Extract ◽  
Oxygen Species

scholarly journals Osmotic Stress Activates Two Reactive Oxygen Species Pathways with Distinct Effects on Protein Nanodomains and Diffusion

2019 ◽  
Vol 179 (4) ◽  
pp. 1581-1593 ◽  
Author(s):  
Alexandre Martinière ◽  
Jean Bernard Fiche ◽  
Marija Smokvarska ◽  
Stéphane Mari ◽  
Carine Alcon ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Osmotic Stress ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
And Diffusion
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