Rosemary extract modulates stress resistance and accumulation of reactive oxygen species in the model organism Caenorhabditis elegans

2020 ◽  
Vol 14 ◽  
pp. 100233
Author(s):  
Christina Saier ◽  
Stephanie Storbeck ◽  
Sabrina Baier ◽  
Heiko Dietz ◽  
Wim Wätjen
Keyword(s):  
Reactive Oxygen Species ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Model Organism ◽  
Reactive Oxygen ◽  
Rosemary Extract ◽  
Oxygen Species

scholarly journals Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B

2020 ◽  
Vol 17 (5) ◽  
pp. 1572
Author(s):  
Shi-ming Li ◽  
Dan Liu ◽  
Yi-lin Liu ◽  
Bin Liu ◽  
Xing-huang Chen
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Reactive Oxygen ◽  
Species Level ◽  
Ultraviolet B ◽  
Oxygen Species ◽  
Germ Cell Apoptosis ◽  
Embryonic Lethal

Ultraviolet B (UV-B, 280–320 nm) radiation causes complex molecular reactions in cells, including DNA damage, oxidative stress, and apoptosis. This study designed a mixture consisting of quercetin, luteolin and lycopene and used Caenorhabditis elegans as a model to study the resistance of these natural chemicals to UV-B. Specifically, we have confirmed that quercetin and its mixture can increase the resistance of Caenorhabditis elegans to UV-B through lifespan test, reactive oxygen species level assay, germ cell apoptosis test, embryonic lethal test and RT-qPCR experiments. The results show that quercetin and its mixture prolonged the lifespan of UV-B-irradiated Caenorhabditis elegans and reduced abnormal levels of reactive oxygen species, embryo death, and apoptosis induced by UV-B. The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1, CEP-1, EGL-1 and CED-13. Therefore, the results of this research could help the development of UV-B radiation protection agents.

scholarly journals Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

PLoS Genetics ◽  
2018 ◽  
Vol 14 (3) ◽  
pp. e1007268 ◽  
Author(s):  
Megan M. Senchuk ◽  
Dylan J. Dues ◽  
Claire E. Schaar ◽  
Benjamin K. Johnson ◽  
Zachary B. Madaj ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Caenorhabditis Elegans ◽  
Reactive Oxygen ◽  
Oxygen Species
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