scholarly journals Maternal cerebellar gray matter volume is associated with daughters’ psychotic experience

2020 ◽  
Vol 74 (7) ◽  
pp. 392-397
Author(s):  
Naoki Hashimoto ◽  
Timothy I. Michaels ◽  
Roeland Hancock ◽  
Ichiro Kusumi ◽  
Fumiko Hoeft



2000 ◽  
Vol 47 (8) ◽  
pp. S37
Author(s):  
E.V. Sullivan ◽  
A. Deshmukh ◽  
J.E. Desmond ◽  
D.H. Mathalon ◽  
M.J. Rosenbloom ◽  
...  


2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  


PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171457 ◽  
Author(s):  
Antonio Cerasa ◽  
Alessia Sarica ◽  
Iolanda Martino ◽  
Carmelo Fabbricatore ◽  
Francesco Tomaiuolo ◽  
...  


2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hiroyuki Sakai ◽  
Takafumi Ando ◽  
Norihiro Sadato ◽  
Yuji Uchiyama


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Weipeng Liu ◽  
Hao Yan ◽  
Danyang Zhou ◽  
Xin Cai ◽  
Yuyanan Zhang ◽  
...  

AbstractMajor depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD cases and 3031 controls), we conducted replication analyses of two genetic loci highlighted in a previous Chinese MDD genome-wide association study (GWAS), and confirmed the significant association of a single nucleotide polymorphism (SNP) rs12415800 near SIRT1. Subsequently, using hypothesis-free whole-brain analysis in two independent Han Chinese imaging samples, we found that individuals carrying the MDD risk allele of rs12415800 exhibited aberrant gray matter volume in the left posterior cerebellar lobe compared with those carrying the non-risk allele. Besides, in independent Han Chinese postmortem brain and peripheral blood samples, the MDD risk allele of rs12415800 predicted lower SIRT1 mRNA levels, which was consistent with the reduced expression of this gene in MDD patients compared with healthy subjects. These results provide further evidence for the involvement of SIRT1 in MDD, and suggest that this gene might participate in the illness via affecting the development of cerebellum, a brain region that is potentially underestimated in previous MDD studies.



2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kyu-In Jung ◽  
Min-Hyeon Park ◽  
Bumhee Park ◽  
Shin-Young Kim ◽  
Yae On Kim ◽  
...  


Neurology ◽  
2006 ◽  
Vol 67 (8) ◽  
pp. 1452-1456 ◽  
Author(s):  
C. Daniels ◽  
M. Peller ◽  
S. Wolff ◽  
K. Alfke ◽  
K. Witt ◽  
...  


Author(s):  
Rieko Osu ◽  
Towa Morita ◽  
Satoshi Tanaka ◽  
Yuko Isogaya ◽  
Hiroki Kurashige ◽  
...  


2019 ◽  
Vol 86 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Torgeir Moberget ◽  
Dag Alnæs ◽  
Tobias Kaufmann ◽  
Nhat Trung Doan ◽  
Aldo Córdova-Palomera ◽  
...  


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