Cutaneous polyarteritis nodosa in pediatric patients successfully treated with TNF‐α inhibitor and methotrexate: Case series and literature review

2019 ◽  
Vol 36 (6) ◽  
pp. 932-935 ◽  
Author(s):  
Ngan Do ◽  
Sarah Ringold ◽  
Heather Brandling‐Bennett
Keyword(s):  
Literature Review ◽  
Polyarteritis Nodosa ◽  
Pediatric Patients ◽  
Case Series ◽  
Cutaneous Polyarteritis Nodosa ◽  
Tnf Α

The natural history of laryngo‐onycho‐cutaneous syndrome: A case series of six pediatric patients and literature review

2021 ◽  
Author(s):  
Christine Prodinger ◽  
Subhanitthaya Chottianchaiwat ◽  
Jemima E. Mellerio ◽  
John A. McGrath ◽  
Linda Ozoemena ◽  
...  
Keyword(s):  
Natural History ◽  
Literature Review ◽  
Pediatric Patients ◽  
Case Series ◽  
History Of

Epidemiological, clinical and laboratory profiles of cutaneous polyarteritis nodosa patients: Report of 22 cases and literature review

2016 ◽  
Vol 15 (6) ◽  
pp. 558-563 ◽  
Author(s):  
Paulo Ricardo Criado ◽  
Gabriela Franco Marques ◽  
Thamara Cristiane Alves Batista Morita ◽  
Jozélio Freire de Carvalho
Keyword(s):  
Literature Review ◽  
Polyarteritis Nodosa ◽  
Cutaneous Polyarteritis Nodosa

Antitumor Necrosis Factor-α Therapy Associated with Inflammatory Bowel Disease: Three Cases and a Systematic Literature Review

2017 ◽  
Vol 44 (7) ◽  
pp. 1088-1095 ◽  
Author(s):  
Amir Bieber ◽  
Abdallah Fawaz ◽  
Irina Novofastovski ◽  
Reuven Mader
Keyword(s):  
Inflammatory Bowel Disease ◽  
Literature Review ◽  
Bowel Disease ◽  
Gastrointestinal Symptoms ◽  
Case Series ◽  
Patient Specific ◽  
Tnf Α ◽  
Inflammatory Bowel ◽  
Factor Α ◽  
Necrosis Factor

Objective.Antitumor necrosis factor-α (anti-TNF-α) therapy is the most prescribed biologic agent therapy in rheumatology and gastroenterology. However, a number of serious side effects have been reported with these drugs. Only a handful of cases of new-onset inflammatory bowel disease (IBD), mostly in children diagnosed with juvenile idiopathic arthritis (JIA), have been reported during anti-TNF-α therapy. We present 3 cases of adult IBD following anti-TNF-α therapy and a literature review on this topic.Methods.We searched PubMed MESH for all relevant terms, papers were reviewed, and patient-specific data were extracted. Relevant clinical data were calculated and presented.Results.The PubMed search resulted in 137 articles, of which 11 articles and 4 cited publications were included in our analysis. We found 53 cases of IBD after anti-TNF-α therapy reported in the literature; most of them were case series collected retrospectively from national databases or studies. Almost all the patients developed IBD after the introduction of etanercept (ETN); 2 patients with rheumatoid arthritis were also included. The average age at IBD onset was 17.3 years and the average time from ETN introduction to IBD onset was 27 months (± 24). Gastrointestinal symptoms have been reported as improving or subsiding in most of the patients after discontinuing ETN.Conclusion.Although this manifestation is not common, it should be taken into consideration as an adverse effect of ETN. Rheumatologists, and in particular rheumatologists treating adult patients, should be aware of this possible complication. Further investigation about the pathogenic process underlying this phenomenon is warranted.

Mutation spectrum of MMACHC in Chinese pediatric patients with cobalamin C disease: A case series and literature review

2019 ◽  
Vol 62 (10) ◽  
pp. 103713 ◽  
Author(s):  
Chao Wang ◽  
Dong Li ◽  
Fengying Cai ◽  
Xinjie Zhang ◽  
Xiaowei Xu ◽  
...  
Keyword(s):  
Literature Review ◽  
Pediatric Patients ◽  
Case Series ◽  
Mutation Spectrum

Therapeutic options for cutaneous polyarteritis nodosa: a systematic review

Rheumatology ◽  
2021 ◽  
Author(s):  
Eleni Papachristodoulou ◽  
Loukas Kakoullis ◽  
Eleni Tiniakou ◽  
Konstantinos Parperis
Keyword(s):  
Systematic Review ◽  
Polyarteritis Nodosa ◽  
Immunosuppressive Agents ◽  
Case Series ◽  
Treatment Modalities ◽  
Induction Treatment ◽  
Cutaneous Polyarteritis Nodosa ◽  
Systemic Corticosteroids ◽  
Increased Risk ◽  
Effect Of Treatment

Abstract Objective Cutaneous polyarteritis nodosa (CPAN) is a necrotizing vasculitis of the middle-size vessels, confined to the skin. We conducted a systematic review in order to identify studies evaluating the different treatment modalities used in CPAN. Methods This systematic review was conducted according to PRISMA guidelines, registered in PROSPERO: CRD42020222195. PubMed/Medline databases were searched from inception to December of 2020 using the terms: “Polyarteritis nodosa[Title/Abstract]) AND ((therapy[Title/Abstract]) OR (management[Title/Abstract]) OR (treatment[Title/Abstract]))” and “Cutaneous arteritis [Title/Abstract]”. Articles evaluating pertaining to the management of CPAN in adults were eligible for inclusion. Results A total of 7 eligible case series with 325 unique patients were included. No study included a control population. In general, systemic corticosteroids were widely used as induction treatment. Immunosuppressive agents combined with corticosteroids were azathioprine, hydroxychloroquine, sulfasalazine, sulphapyridine, cyclophosphamide, methotrexate, mycophenolate, tacrolimus, rituximab, and thalidomide. Other agents utilized in the studies were dapsone, colchicine, non-steroid anti-inflammatory drugs, salicylates, warfarin and clopidogrel. In some studies, the presence of ulcerations was associated with an increased risk of relapse. Conclusion The evidence available regarding the management of patients with CPAN is limited at best. Further studies are needed in order to evaluate the effect of treatment on disease remission, relapses, and mortality.

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