Epidermal necrolysis as the presenting manifestation of pediatric lupus

2020 ◽  
Vol 37 (6) ◽  
pp. 1119-1124
Author(s):  
Dharmagat Bhattarai ◽  
Pandiarajan Vignesh ◽  
Himanshi Chaudhary ◽  
Niteesh Bharadwaj ◽  
Lokesh Saini ◽  
...  
Keyword(s):  
Pediatric Lupus

A32: Low Vitamin D Status is Associated with Avascular Necrosis: An Atherosclerosis Prevention in Pediatric Lupus Erythematosus Substudy

2014 ◽  
Vol 66 ◽  
pp. S49-S50 ◽  
Author(s):  
Reut Gurion ◽  
Vin Tangpricha ◽  
Eric Yow ◽  
Laura E. Schanberg ◽  
Grace McComsey ◽  
...  
Keyword(s):  
Vitamin D ◽  
Avascular Necrosis ◽  
Lupus Erythematosus ◽  
Vitamin D Status ◽  
Pediatric Lupus ◽  
Atherosclerosis Prevention

Antiphospholipid antibodies in pediatric lupus nephritis

1997 ◽  
Vol 29 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Susan F. Massengill ◽  
Claire Hedrick ◽  
Elia M. Ayoub ◽  
John W. Sleasman ◽  
Kuo Jang Kao
Keyword(s):  
Lupus Nephritis ◽  
Antiphospholipid Antibodies ◽  
Pediatric Lupus

Pediatric lupus: Similarities and differences from adult onset lupus

1998 ◽  
Vol 18 (10) ◽  
pp. 118-121
Author(s):  
Marisa Klein-Gitelman
Keyword(s):  
Adult Onset ◽  
Pediatric Lupus ◽  
Similarities And Differences

scholarly journals Understanding patient-provider discordance in adolescents with lupus: The role of pain and antidepressant medication use

2020 ◽  
Vol 7 (2) ◽  
pp. 205510292097771
Author(s):  
Kathleen Kenney-Riley ◽  
Shari Salzhauer Berkowitz ◽  
Kimberly Rapoza
Keyword(s):  
Disease Activity ◽  
Secondary Analysis ◽  
Medication Use ◽  
Antidepressant Medication ◽  
Childhood Arthritis ◽  
Pain Scores ◽  
Pediatric Lupus ◽  
Research Alliance ◽  
Lupus Disease Activity

The current study examines depression and pain as potential contributors to patient-provider discordance in the assessment of lupus disease activity. The study conducted a secondary analysis of data obtained from the Childhood Arthritis and Rheumatology Research Alliance registry, with N = 859 adolescent participants. Assessments of pain, disease activity, and antidepressant medication use were collected from the patient and provider. Results indicated that depression might be underdiagnosed in pediatric lupus patients. While psychotropic medication and pain scores were independently related to greater patient-provider discordance regarding health status, pain mediated this relationship. Implications for treatment outcomes are discussed.

scholarly journals 129 Macrophage activation syndrome as a presentation in pediatric lupus: a retrospective study of 3 cases

2019 ◽  
Author(s):  
Ankita Singh ◽  
Rakesh Pilania ◽  
Sandesh Guleria ◽  
Nameirakpam Johnson ◽  
Gummadi Anjani ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Pediatric Lupus ◽  
Activation Syndrome

scholarly journals Double negative T cells, a potential biomarker for systemic lupus erythematosus

2020 ◽  
Vol 3 (1) ◽  
pp. 34-43
Author(s):  
Jessy J Alexander ◽  
Alexander Jacob ◽  
Anthony Chang ◽  
Richard J Quigg ◽  
James N Jarvis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Kidney Function ◽  
Lupus Erythematosus ◽  
Direct Evidence ◽  
Kidney Injury ◽  
Systemic Lupus ◽  
Potential Biomarker ◽  
Pediatric Lupus ◽  
First Time

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, the CD3+CD4−CD8− (DNeg) cells, is significantly increased in lupus patients. Twenty-seven cases (53%) of pediatric SLE patients had elevated DNeg cells in their peripheral blood, which correlated with kidney function (R2 = 0.54). Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence. For the first time, this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice. In lupus mice, the increase in DNeg cells tracked with worsening disease and correlated with kidney function (R2 = 0.85). Our results show that DNeg cells per se can cause kidney dysfunction, increase in number with increase in disease pathology, and could serve as a potential biomarker.

Disease activity and health-care utilization among young adults with childhood-onset lupus transitioning to adult care: data from the Pediatric Lupus Outcomes Study

Lupus ◽  
2020 ◽  
Vol 29 (10) ◽  
pp. 1206-1215
Author(s):  
Sara L Haro ◽  
Erica F Lawson ◽  
Aimee O Hersh
Keyword(s):  
Health Care ◽  
Young Adults ◽  
Health Care Utilization ◽  
Disease Activity ◽  
Care Utilization ◽  
Childhood Onset ◽  
Adult Care ◽  
Medication Usage ◽  
Pediatric Lupus ◽  
Outcomes Study

Background Individuals with childhood-onset systemic lupus erythematosus (cSLE) must transfer from pediatric to adult care. The goal of this study was to examine disease activity and health-care utilization among young adults with cSLE who are undergoing or have recently completed the transfer to adult care. Methods The Pediatric Lupus Outcomes Study (PLOS) is a prospective longitudinal cohort study of young adults aged 18–30 diagnosed with cSLE. We conducted a cross-sectional analysis comparing 47 participants under the care of pediatric rheumatologists to 38 who had completed transfer to adult care. Demographics, disease manifestations, health- care utilization and transition readiness were compared between groups. Results Those in the post-transfer group had significantly lower medication usage and were less likely to have seen a rheumatologist in the past year. Disease manifestations, flare rates, and hospitalizations were similar between groups. Nearly a quarter of patients who had transferred to adult care reported difficulties with the process. Conclusion Post-transfer patients had lower health-care utilization as evidenced by less medication usage and lack of rheumatology follow-up, in spite of the fact that disease activity was similar in both groups. Future studies will assess longitudinal changes in disease activity and damage in this population.

scholarly journals Pediatric lupus nephritis: impact of ethnicity on histological subtype and initial presentation

2008 ◽  
Vol 6 (S1) ◽  
Author(s):  
R Jurencak ◽  
PN Tyrrell ◽  
SM Benseler ◽  
LT Hiraki ◽  
ED Silverman
Keyword(s):  
Lupus Nephritis ◽  
Initial Presentation ◽  
Histological Subtype ◽  
Pediatric Lupus

scholarly journals Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry

2018 ◽  
Vol 70 (3) ◽  
pp. 420-427 ◽  
Author(s):  
Tamar B. Rubinstein ◽  
Wenzhu B. Mowrey ◽  
Norman T. Ilowite ◽  
Dawn M. Wahezi ◽  
Keyword(s):  
Rheumatology Research ◽  
Childhood Arthritis ◽  
Pediatric Lupus ◽  
Research Alliance

CURRENT ISSUES IN PEDIATRIC LUPUS NEPHRITIS: ROLE OF REVISED HISTOPATHOLOGICAL CLASSIFICATION

2006 ◽  
Vol 25 (6) ◽  
pp. 297-309 ◽  
Author(s):  
Stephen D. Marks ◽  
Kjell Tullus ◽  
Neil J. Sebire
Keyword(s):  
Lupus Nephritis ◽  
Histopathological Classification ◽  
Pediatric Lupus
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