Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment

2021 ◽  
Author(s):  
Penelope Kallis ◽  
Elizabeth Bisbee ◽  
Cheryl Garganta ◽  
Jennifer J. Schoch
Keyword(s):  
Skin Lesions ◽  
Rapid Improvement ◽  
Child Syndrome

Stun Gun Injury: A New Presentation of the Battered Child Syndrome

PEDIATRICS ◽  
1992 ◽  
Vol 89 (5) ◽  
pp. 898-901
Author(s):  
Alan Frechette ◽  
Mary Ellen Rimsza
Keyword(s):  
Child Abuse ◽  
Skin Lesions ◽  
Battered Child Syndrome ◽  
Battered Child ◽  
Child Syndrome ◽  
Protection Devices ◽  
Self Protection ◽  
Stun Gun

Stun guns are self-protection devices that are increasingly available with few restrictions on their use and sale. We present a case of child abuse with a stun gun. The signs of such abuse are often subtle, and they may be underrecognized currently. The skin lesions that are often seen are hypopigmented circular macules, measuring approximately 0.5 cm in diameter. They may be raised slightly and erythematous if inflicted recently. Most characteristic of stun gun assault is pairing of lesions approximately 5 cm apart. We discuss the design, operation, and effects of stun guns, and give an extensive differential of abusive and nonabusive circular lesions.

Subacute Cutaneous Lupus Erythematosus Induced by Nifedipine

2003 ◽  
Vol 7 (3) ◽  
pp. 243-246 ◽  
Author(s):  
Emanuela Gubinelli ◽  
Barbara Cocuroccia ◽  
Giampiero Girolomoni
Keyword(s):  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Skin Lesions ◽  
Channel Blockers ◽  
Subacute Cutaneous Lupus Erythematosus ◽  
Rapid Improvement ◽  
Drug Induced ◽  
Dermoepidermal Junction ◽  
Antihistone Antibody ◽  
Cutaneous Lupus

Background: Subacute cutaneous lupus erythematosus (SCLE) has been reported to be associated with the use of several drugs, including thiazides, terbinafine, and, rarely, calcium channel blockers. Objective: A case of SCLE induced by nifedipine is presented. Methods and Results: A 48-year-old white woman developed a papulosquamous and annular eruption in sun-exposed areas during the summer. The patient was taking nifedipine for essential hypertension for four years. Serology showed the presence of antinuclear and anti-Ro/SSA as well as antihistone antibodies. Histopathologic and immunopathologic (granular IgM deposits at the dermoepidermal junction) findings confirmed the diagnosis of SCLE. Nifedipine discontinuation led to rapid improvement with almost complete resolution of skin lesions in one month in the absence of active treatment. Reduction of antinuclear, anti-Ro/SSA, and antihistone antibody levels was documented after six months. Conclusion: Nifedipine can cause SCLE after a long period of administration. Antihistone antibodies may be associated with drug-induced SCLE.

RAPID IMPROVEMENT OF SKIN LESIONS IN GLUCAGONOMAS WITH INTRAVENOUS SOMATOSTATIN INFUSION

The Lancet ◽  
1980 ◽  
Vol 315 (8158) ◽  
pp. 40 ◽  
Author(s):  
J. Sohier ◽  
M. Jeanmougin ◽  
P. Lombrail ◽  
PH. Passa
Keyword(s):  
Skin Lesions ◽  
Rapid Improvement

CHILD Syndrome: Successful Treatment of Skin Lesions with Topical Simvastatin/Cholesterol Ointment-A Case Report

2015 ◽  
Vol 32 (4) ◽  
pp. e145-e147 ◽  
Author(s):  
Alexios Alexopoulos ◽  
Talia Kakourou
Keyword(s):  
Case Report ◽  
Successful Treatment ◽  
Skin Lesions ◽  
Child Syndrome

scholarly journals Pyoderma Gangrenosum Induced by BNT162b2 COVID-19 Vaccine in a Healthy Adult

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 87
Author(s):  
Mazin Barry ◽  
Abdulaziz AlRajhi ◽  
Khaldoon Aljerian
Keyword(s):  
Pyoderma Gangrenosum ◽  
Messenger Rna ◽  
Skin Lesions ◽  
Neutrophilic Dermatosis ◽  
Unknown Etiology ◽  
Rapid Improvement ◽  
Inflammatory Infiltration ◽  
Cutaneous Manifestations ◽  
Wide Scale ◽  
Monitoring And Surveillance

(1) Background: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis of unknown etiology. Coronavirus disease 2019 (COVID-19) vaccines can cause a variety of adverse cutaneous manifestations. PG associated with mRNA vaccines has not previously been described. This case study reports on the first patient to develop PG after receiving BNT162b2. (2) Case Presentation: An otherwise-healthy 27-year-old man developed multiple skin lesions 24 h after receiving the first dose of the messenger RNA-based Pfizer/BioNTech BNT162b2 COVID-19 vaccine. When in hospital, he developed a new painful ulcerative lesion on his right hand. Skin ulcer edge biopsy showed severe epidermal neutrophilic infiltrate with epidermal and dermal edema, underlying superficial dermal necrosis, and characteristic undermining with extensive mixed inflammatory infiltration of the dermis and abscess formation consistent with an ulcer with mixed dermal inflammation compatible with pyoderma gangrenosum. The lesion showed rapid improvement after the initiation of immunosuppressive therapy. (3) Conclusions: PG may be a rare adverse event related to the BNT162b2 vaccine, which could be more frequently encountered with the wide-scale use of mRNA vaccines. The continuous monitoring and surveillance of skin manifestations post-vaccination is essential.

scholarly journals CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion

2019 ◽  
Vol 94 (3) ◽  
pp. 341-343 ◽  
Author(s):  
Karina Romero Sandoval ◽  
Maria Cecília Rivitti Machado ◽  
Zilda Najjar Prado de Oliveira ◽  
Marcello Menta Simonsen Nico
Keyword(s):  
Successful Treatment ◽  
Skin Lesions ◽  
Child Syndrome

scholarly journals Goeckerman Regimen as an Effective Treatment Modality for Checkpoint Inhibitor Dermatoses

2021 ◽  
Vol 5 (5) ◽  
pp. 554-558
Author(s):  
Nicholas Brownstone ◽  
Daniel Cummins ◽  
Jocelyn Gandelman ◽  
Tina Bhutani ◽  
Wilson Liao
Keyword(s):  
San Francisco ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Treatment Method ◽  
Skin Lesions ◽  
Treatment Center ◽  
Rapid Improvement ◽  
Effective Treatment Modality ◽  
Goeckerman Regimen

The development of immune checkpoint inhibitors has been a major breakthrough in cancer therapy. Here, we report the effective use of the Goeckerman regimen in the treatment of an evolving immune checkpoint inhibitor dermatosis. The patient is a 67-year-old male who was diagnosed with mesothelioma in April 2015 and was started on pembrolizumab presenting with subsequent skin eruptions (psoriasiform dermatitis and bullous disease). He received eight months of Goeckerman therapy at University of California, San Francisco, Psoriasis and Skin Treatment Center. Within days of starting Goeckerman therapy, he had rapid improvement in his skin lesions along with a reduction in pruritus. The Goeckerman regimen is further discussed as a novel treatment method for checkpoint inhibitor dermatoses.

scholarly journals NSDHL Frameshift Deletion in a Mixed Breed Dog with Progressive Epidermal Nevi

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1297
Author(s):  
Matthias Christen ◽  
Michaela Austel ◽  
Frane Banovic ◽  
Vidhya Jagannathan ◽  
Tosso Leeb
Keyword(s):  
Current Knowledge ◽  
Stop Codon ◽  
Cholesterol Biosynthesis ◽  
Companion Animals ◽  
Premature Stop Codon ◽  
Skin Lesions ◽  
Loss Of Function ◽  
Human Sequence ◽  
Frameshift Deletion ◽  
Child Syndrome

Loss-of-function variants in the NSDHL gene have been associated with epidermal nevi in humans with congenital hemidysplasia, ichthyosiform nevi, and limb defects (CHILD) syndrome and in companion animals. The NSDHL gene codes for the NAD(P)-dependent steroid dehydrogenase-like protein, which is involved in cholesterol biosynthesis. In this study, a female Chihuahua cross with a clinical and histological phenotype consistent with progressive epidermal nevi is presented. All exons of the NSDHL candidate gene were amplified by PCR and analyzed by Sanger sequencing. A heterozygous frameshift variant, c.718_722delGAACA, was identified in the affected dog. In lesional skin, the vast majority of NSDHL transcripts lacked the five deleted bases. The variant is predicted to produce a premature stop codon truncating 34% of the encoded protein, p.Glu240Profs*17. The mutant allele was absent from 22 additionally genotyped Chihuahuas, as well as from 647 control dogs of diverse breeds and eight wolves. The available experimental data together with current knowledge about NSDHL variants and their functional impact in humans, dogs, and other species prompted us to classify this variant as pathogenic according to the ACMG guidelines that were previously established for human sequence variants. Therefore, we propose the c.718_722delGAACA variant as causative variant for the observed skin lesions in this dog.

scholarly journals Improvement of skin lesions in corticosteroid withdrawal-associated severe eczema by multicomponent traditional Chinese medicine therapy

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Serife Uzun ◽  
Zixi Wang ◽  
Tory A. McKnight ◽  
Paul Ehrlich ◽  
Erin Thanik ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Withdrawal Syndrome ◽  
Medical Condition ◽  
Skin Lesions ◽  
High Dose ◽  
Topical Steroids ◽  
Rapid Improvement ◽  
Corticosteroid Withdrawal ◽  
Severe Eczema

Abstract Rationale We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old male with refractory disease and corticosteroid withdrawal syndrome. Methods Prior to referral, the patient had been treated since infancy with increasingly intensive standard of care, including high-dose topical and systemic corticosteroid and antibiotic therapy and was unable to tolerate further steroid treatment. The patient was administered a combination of oral and topical TCM for 17 months following discontinuation of his steroid regimen. His overall medical condition was assessed by SCORAD criteria and laboratory evaluations of serum IgE, absolute eosinophil count, and liver and kidney function tests. Results The patient showed rapid improvement of clinical measures of disease after starting TCM therapy, with marked improvement of sleep quality within the first week, complete resolution of itching, oozing, and erythema at 2 weeks, and a 79% and 99% decrease in his SCORAD values after one month and 3–6 months of TCM, respectively. Serum total IgE decreased by 75% (from 19,000 to 4630 (kIU/L), and absolute eosinophil counts decreased by 60% (from 1000 to 427 cells/μL) after 12 months of treatment. The patient did not require oral or topical steroids during the 17-month trial of TCM. TCM was tapered without complications. His dermatologic manifestations continued to be well-controlled 3 months after discontinuation. Conclusion This case study suggests TCM should be further evaluated in controlled clinical studies of patients with severe, refractory eczema and steroid withdrawal syndrome.

CHILD syndrome with mild skin lesions: histopathologic clues for the diagnosis

2014 ◽  
Vol 41 (10) ◽  
pp. 787-790 ◽  
Author(s):  
Susanne Gantner ◽  
Arno Rütten ◽  
Luis Requena ◽  
Gerhard Gassenmaier ◽  
Michael Landthaler ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Child Syndrome
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