scholarly journals Indicators of unresponsiveness after initial i.v. immunoglobulin treatment in acute Kawasaki disease

2019 ◽  
Vol 61 (7) ◽  
pp. 641-646
Author(s):  
Ikuo Hashimoto
Keyword(s):  
Kawasaki Disease ◽  
Acute Kawasaki Disease ◽  
Immunoglobulin Treatment

Efficacy of Intravenous Immunoglobulin Combined with Prednisolone Following Resistance to Initial Intravenous Immunoglobulin Treatment of Acute Kawasaki Disease

2013 ◽  
Vol 163 (2) ◽  
pp. 521-526.e1 ◽  
Author(s):  
Tohru Kobayashi ◽  
Tomio Kobayashi ◽  
Akihiro Morikawa ◽  
Kentaro Ikeda ◽  
Mitsuru Seki ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Acute Kawasaki Disease ◽  
Immunoglobulin Treatment

scholarly journals Crucial transcripts predict response to initial immunoglobulin treatment in acute Kawasaki disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhimin Geng ◽  
Jingjing Liu ◽  
Jian Hu ◽  
Ying Wang ◽  
Yijing Tao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kawasaki Disease ◽  
Clinical Response ◽  
Cell Activation ◽  
Myeloid Cell ◽  
Gene Expression Omnibus ◽  
Ivig Treatment ◽  
Precise Diagnosis ◽  
Acute Kawasaki Disease ◽  
Immunoglobulin Treatment

Abstract Although intravenous immunoglobulin (IVIG) can effectively treat Kawasaki disease (KD), 10–20% of KD patients show no beneficial clinical response. Developing reliable criteria to discriminate non-responders is important for early planning of appropriate regimens. To predict the non-responders before IVIG treatment, gene expression dataset of 110 responders and 61 non-responders was obtained from Gene Expression Omnibus. After weighted gene co-expression network analysis, we found that modules positively correlated with the non-responders were mainly associated with myeloid cell activation. Transcripts up-regulated in the non-responders, IL1R2, GK, HK3, C5orf32, CXCL16, NAMPT and EMILIN2, were proven to play key roles via interaction with other transcripts in co-expression network. The crucial transcripts may affect the clinical response to IVIG treatment in acute KD. And these transcripts may serve as biomarkers and therapeutic targets for precise diagnosis and treatment of the non-responders.

Therapy of acute Kawasaki disease

1991 ◽  
Vol 1 (3) ◽  
pp. 254-255
Author(s):  
Jane W. Newburger
Keyword(s):  
Myocardial Infarction ◽  
Early Childhood ◽  
Kawasaki Disease ◽  
Sudden Death ◽  
Cervical Lymphadenopathy ◽  
Unknown Etiology ◽  
Acute Kawasaki Disease ◽  
Arterial Insufficiency ◽  
Infancy And Early Childhood ◽  
Arterial Aneurysms

Kawasaki disease is an acute vasculitis of unknown etiology that occurs predominantly in infancy and early childhood. It is characterize by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy.1,2 Coronary arterial aneurysms, or ectasia, develop in approximately 15 to 25% of children with the disease, and may lead to myocardial infarction, sudden death, or chronic coronary arterial insufficiency.2–4

Arthritis in Kawasaki disease after responding to intravenous immunoglobulin treatment

2005 ◽  
Vol 164 (7) ◽  
pp. 451-452 ◽  
Author(s):  
Kyung-Yil Lee ◽  
Jin-Hee Oh ◽  
Ji-Whan Han ◽  
Joon-Sung Lee ◽  
Byung-Churl Lee
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Immunoglobulin Treatment

scholarly journals Use of Adjunctive Therapy in Acute Kawasaki Disease in Latin America

2020 ◽  
Vol 8 ◽  
Author(s):  
Brenda Fortuna-Reyna ◽  
Emelia V. Bainto ◽  
Rolando Ulloa-Gutierrez ◽  
Luis M. Garrido-García ◽  
Dora Estripeaut ◽  
...  
Keyword(s):  
Latin America ◽  
Kawasaki Disease ◽  
Adjunctive Therapy ◽  
Acute Kawasaki Disease
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