Singlet Oxygen Activatable Prodrugs of Paclitaxel, SN‐38, MMC, and CA4: Non‐mitochondria Targeted Prodrugs

2021 ◽  
Author(s):  
Kazi Md Mahabubur Rahman ◽  
Pritam Thapa ◽  
Robert Hurst ◽  
Sukyung Woo ◽  
Youngjae You
Keyword(s):  
Singlet Oxygen

Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity

1998 ◽  
Vol 67 (4) ◽  
pp. 399 ◽  
Author(s):  
Lydia J. Martínez ◽  
Robert H. Sik ◽  
Colin F. Chignell
Keyword(s):  
Singlet Oxygen

A singlet oxygen sensor for photodynamic cancer therapy

1999 ◽  
Author(s):  
Philip B. Keating ◽  
Michael F. Hinds ◽  
Steven J. Davis
Keyword(s):  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Oxygen Sensor ◽  
Photodynamic Cancer Therapy

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Parametric study of a mist jet-singlet oxygen generator.

2000 ◽  
Vol 12 (1/2) ◽  
pp. 136-137
Author(s):  
Shigeki MUTO ◽  
Yosuke KOBAYASHI ◽  
Yoshinobu TAKEKAWA ◽  
Masamori ENDO ◽  
Kenzo NANRI ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Parametric Study ◽  
Oxygen Generator ◽  
Singlet Oxygen Generator
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