Discontinuous unilateral involvement of 12 part core biopsies by adenocarcinoma predicts bilateral involvement of subsequent radical prostatectomy

Objective: The aim of the study was to determine the risk of multiple sclerosis (MS) conversion after optic neuritis (ON) and to identify the predictive factors on conversion in Turkish patients. Methods: Patients whose first clinical attacks had been ON were included in the study. The primary end point was the diagnosis of clinical relapse-remitting MS. Result: Except for the bilateral involvement rate, the clinical and demographic characteristics of the cohort are similar to Western studies. Though one-third of the patients with ON had bilateral involvement, bilateral involvement reduces the risk of conversion. Also, active lesions at the initial cranial magnetic resonance imagination increase the conversion rate. Conclusion: This research confirms previous findings and contributes additional evidence that if the patients have unilateral involvement and active lesions, they should be closely monitored. Moreover, our research supports the hypothesis that risk factors may be affected by racial, environmental, and genetic factors.

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Streptomycin treatment in Meniere's disease

Otolaryngology ◽

10.1177/019459988709600305 ◽

1987 ◽

Vol 96 (3) ◽

pp. 256-259 ◽

Cited By ~ 14

Author(s):

William H. Moretz ◽

John J. Shea ◽

Daniel J. Orchik ◽

John R. Emmett ◽

JOhn J. Shea

Keyword(s):

Hearing Loss ◽

Meniere’S Disease ◽

Menière’S Disease ◽

Meniere's Disease ◽

Ménière’S Disease ◽

Menière's Disease ◽

Bilateral Involvement ◽

Ménière's Disease ◽

Unilateral Involvement ◽

Special Case

Streptomycin treatment in Meniere's disease has traditionally been used for control of vertigo in patients with severe bilateral involvement or unilateral involvement in the only hearing ear. Guidelines for use that have worked at the Shea Clinic are presented. in addition, a special case is discussed in which this form of therapy has been used for treatment of fluctuant hearing loss in a patient with Meniere's disease.

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Chest computed tomographic findings of patients with COVID-19-related pneumonia

Acta Radiologica Open ◽

10.1177/2058460121989309 ◽

2021 ◽

Vol 10 (2) ◽

pp. 205846012198930

Author(s):

Şaban Tiryaki ◽

Hakan Dabeşlim ◽

Yusuf Aksu

Keyword(s):

Lung Parenchyma ◽

Thoracic Radiography ◽

Pulmonary Lesions ◽

Computed Tomographic ◽

Bilateral Involvement ◽

Thoracic Ct ◽

Ct Findings ◽

Unilateral Involvement ◽

Thorax Ct ◽

Age Range

Background In December 2019, pneumonia cases of unknown cause were announced in Wuhan, China. The causative agent of pneumonia was identified as coronavirus 2 (SARS-CoV-2), and the disease was named coronavirus disease 2019 (COVID-19). Purpose To evaluate the usefulness of computed thoracic tomography (CT) and postero anterior (PA) thoracic radiography in patients with COVID-19. Material and Methods Between March and June 2020, the patients who arrived at our hospital with suspicion of COVID-19 were retrospectively analyzed. Thorax CT findings of the 281 patients (142 females and 139 males; age range 3–91 years) with positive PCR tests were evaluated. Lesions in the lung parenchyma were examined according to their number, localization, and distribution. PA chest radiograms were classified into two groups, positive and negative for the lung parenchymal lesions. Results Of the total 281 patients with PCR-positive COVID-19, CT examinations were normal in 107 (38.1%), and positive CT findings for pneumonia were found in 174 patients (61.9%). Bilateral involvement was observed in 100 (57.5%) of the 174 patients with positive CT findings, and unilateral involvement was observed in 74 (42.5%) of them. According to the localization of the lesions, peripheral subpleural distribution occurred in 160 of the 174 patients (91.9). The most common lesion was the ground glass opacities (GGO). In 77 of 281 PCR-positive patients (27.4), pulmonary lesions were found on PA chest radiograms. Conclusion The presence of bilateral posterior subpleural GGO, nodule, and consolidation in thoracic CT are significant in terms of COVID-19 pneumonia.

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Retracted: Histopathological Correlation Between Prostatic Adenocarcinoma in Transrectal Ultrasound Guided Biopsies and Radical Prostatectomy Specimens

Journal of Cancer & Allied Specialties ◽

10.37029/jcas.v6i1.299 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Mohammad Faisal ◽

Hina Tariq

Keyword(s):

Radical Prostatectomy ◽

Gleason Score ◽

National Level ◽

Transrectal Ultrasound ◽

Gleason Grade ◽

Local Data ◽

Grade Group ◽

Regional Lymph Nodes ◽

Gleason Grading ◽

Bilateral Involvement

Introduction: Differences in Gleason grade in transrectal ultrasonography (TRUS) biopsies and radical prostatectomy (RP) specimens are well documented in literature. Keeping in view the limitations of Gleason grading system, Epstein JI grade group system was introduced. Various other parameters also have a significant role in predicting the pathological stage, extraprostatic extension, status of surgical margins and metastatic disease in regional lymph nodes. RP is performed at limited centres in Pakistan. Till date, no comparison of the histopathological findings in 12-core TRUS and RP specimens had been performed at the national level. Our study is aimed at generating local data in this context. Materials and Methods: This was a crosssectional study and non-probability consecutive sampling was performed. It was conducted at Histopathology Department, Shifa International Hospital, Islamabad, from January 2008 to December 2014. Gleason scores of 20 RP specimens were compared to Gleason scores of TRUS biopsies of same patients. Concordance in Gleason score and grade groups with laterality, perineural invasion was also studied. Results: Out of 20 RP cases, 40% (n = 8) had a Gleason score of 6, 30% (n = 6) had score 7, 20% (n = 4) had score 8 and 15% (n = 3) had score 9. Compared to the TRUS biopsy, RP Gleason score was concordant in 11 cases (55%), higher in 7 cases (35%) and lower in 2 cases (10%). TRUS involvement was unilateral in 10 cases (50%) and bilateral in 10 cases (50%). However, bilateral involvement of RP specimen was seen in 14 cases (70%) and unilateral in 6 cases (30%). Thus, better tumour yield was observed in RP specimens i.e., bilateral involvement in RP specimens was found in additional 5 cases (25%). Perineural involvement was higher in RP specimen i.e., 12 cases (60%), compared to 5 cases (25%) in TRUS biopsies. Its concordance was significantly higher in those with Gleason score of equal to or more than 7 (83%) and low in score less than score 7 (17%). Conclusion: When comparing RP to initial TRUS biopsies, Gleason score was upgraded in 35% and downgraded in 10% of cases. Bilateral involvement in 25% of cases of RP specimens was underestimated as unilateral involvement in TRUS biopsies. Perineural involvement with high Gleason score was also seen.

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Characteristics and outcomes of lymphaticovenular anastomosis in older patients with bilateral involvement versus younger patients with unilateral involvement in lower extremity lymphedema

Journal of Vascular Surgery Venous and Lymphatic Disorders ◽

10.1016/j.jvsv.2019.10.013 ◽

2020 ◽

Vol 8 (4) ◽

pp. 646-657 ◽

Cited By ~ 1

Author(s):

Shuhei Yoshida ◽

Isao Koshima ◽

Hirofumi Imai ◽

Toshio Uchiki ◽

Ayano Sasaki ◽

...

Keyword(s):

Lower Extremity ◽

Older Patients ◽

Younger Patients ◽

Bilateral Involvement ◽

Unilateral Involvement

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A Case of Adrenal Histoplasmosis

BIRDEM Medical Journal ◽

10.3329/birdem.v8i1.35046 ◽

2017 ◽

Vol 8 (1) ◽

pp. 77-80 ◽

Cited By ~ 2

Author(s):

Faria Afsana ◽

Kazi Nazmul Hossain ◽

Ashfaq Tareque ◽

Mohammad Feroz Amin ◽

Md Faruque Pathan

Keyword(s):

Adrenal Gland ◽

Adrenal Insufficiency ◽

Pulmonary Infection ◽

Bilateral Involvement ◽

Disseminated Histoplasmosis ◽

Wide Availability ◽

Immunosuppressed Patients ◽

History Of ◽

Adrenal Masses ◽

Unilateral Involvement

Histoplasmosis is a fungal disease that may present as chronic pulmonary infection or in disseminated form. Disseminated histoplasmosis frequently affects the adrenal gland; sometimes adrenal gland may be the only site of demonstrable disease. Unilateral involvement in immunosuppressed patients is the usual presentation but bilateral involvement may be also there. Early diagnosis and treatment may save the patient from catastrophic adrenal insufficiency. Considering the risk of morbidity following adrenal insufficiency and the wide availability of effective treatments, adrenal histoplasmosis must be considered in adults who had adrenal masses. Though asymptomatic adrenal involvement has been described in patients with disseminated histoplasmosis; isolated adrenal involvement with or without adrenal insufficiency as the presenting feature of the disease is rare. In this report, a 42 years male presenting with history of weight loss, fever and later revealed bilateral adrenal mass, who was successfully treated with antifungal drug is described.Birdem Med J 2018; 8(1): 77-80

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