P5‐24: Severity and clinical outcome of SARS‐CoV‐2 infected patients following COVID vaccination – An observational study in Bangladesh

Background: The present study has been conducted to compare regimens containing either of nevirapine (NVP) and efavirenz (EFV) and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV infected patients in respect to clinical outcome and to compare incidence of opportunistic infections among these patients.Methods: This study was an observational study conducted at a tertiary care centre over 105 patients, who were evenly matched and received three antiretroviral drug one of the drug was either nevirapine (NVP) or efavirenz (EFV) and these patients were followed up for 6 months for occurrence of any opportunistic infections during these 6 months.Results: 105 patients were followed for 6 months, the maximum incidence of opportunistic infection (OI’s) was found among patients who were on ZLN (zidovudine, lamivudine, nevirapine) regime i.e. 60% followed by patients who changed their regime from ZLN to TLE i.e. 36.5%, while the least incidence of OI’s was noted among the patients who were on TLE (tenofovir, lamivudine, efavirenz) regime i.e. 28.5%. These differences were found to be statistically significant (p<0.05).Conclusions: EFV containing antiretroviral regimen was associated with superior clinical outcome than NVP containing regimen.

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Vertical transmission and clinical outcome of the neonates born to SARS-CoV-2-positive mothers: a tertiary care hospital-based observational study

BMJ Paediatrics Open ◽

10.1136/bmjpo-2021-001193 ◽

2021 ◽

Vol 5 (1) ◽

pp. e001193

Author(s):

Pradeep Kumar ◽

Fadila ◽

Arun Prasad ◽

Ambrin Akhtar ◽

Bhabesh Kant Chaudhary ◽

...

Keyword(s):

Clinical Outcome ◽

Observational Study ◽

Vertical Transmission ◽

Prospective Observational Study ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Stable Condition ◽

Nasopharyngeal Swab ◽

Care Hospital ◽

Rt Pcr

BackgroundNeonatal transmission of SARS-CoV-2 from positive mothers to their babies has been a real concern, opening the arena of research in this area.ObjectiveTo detect the possibility of vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates and the clinicopathological outcome in them.DesignA single-centre, prospective, observational study involving 47 COVID-19-positive mothers and their neonates.SettingA tertiary care hospital in Eastern India.ParticipantsNeonates born to SARS-CoV-2-infected mothers.Main outcome measuresWe investigated the SARS-CoV-2 positivity rate by real-time reverse transcriptase-PCR (RT-PCR) done twice (on admission and after 24 hours of admission) in neonates born to SARS-CoV-2-positive mothers, who tested RT-PCR positive for this virus in their nasopharyngeal swab. Clinical outcome was also assessed in these neonates during their hospital stay.ResultsOut of 47 neonates born to SARS-CoV-2-positive mothers, four were SARS-CoV-2 positive by RT-PCR. All the neonates in our study were discharged home in stable condition after management of acute complications. None of them required readmission.ConclusionVertical transmission occurs in neonates born to COVID-19-positive mothers; however, the risk is small. Majority of the neonates remain asymptomatic with good clinical outcome.

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