Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study

Vox Sanguinis ◽  
2013 ◽  
Vol 104 (4) ◽  
pp. 342-349 ◽  
Author(s):  
O. Karam ◽  
J. Lacroix ◽  
N. Robitaille ◽  
P. C. Rimensberger ◽  
M. Tucci
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Critically Ill Children

Red blood cell transfusion and immune function in critically ill children: a prospective observational study

Transfusion ◽  
2014 ◽  
Vol 55 (4) ◽  
pp. 766-774 ◽  
Author(s):  
Jennifer A. Muszynski ◽  
Elfaridah Frazier ◽  
Ryan Nofziger ◽  
Jyotsna Nateri ◽  
Lisa Hanson-Huber ◽  
...  
Keyword(s):  
Observational Study ◽  
Blood Cell ◽  
Immune Function ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Prospective Observational Study ◽  
Red Blood Cell Transfusion ◽  
Critically Ill Children

Failure mode and effective analysis ameliorate awareness of medical errors: a 4-year prospective observational study in critically ill children

2015 ◽  
Vol 25 (12) ◽  
pp. 1227-1234 ◽  
Author(s):  
Marco Daverio ◽  
Giuliana Fino ◽  
Brugnaro Luca ◽  
Cristina Zaggia ◽  
Andrea Pettenazzo ◽  
...  
Keyword(s):  
Observational Study ◽  
Critically Ill ◽  
Failure Mode ◽  
Medical Errors ◽  
Prospective Observational Study ◽  
Critically Ill Children ◽  
Effective Analysis

scholarly journals Association of monocyte HLA-DR expression over time with secondary infection in critically ill children: a prospective observational study

2021 ◽  
Author(s):  
Nienke N. Hagedoorn ◽  
Pinar Kolukirik ◽  
Nicole M. A. Nagtzaam ◽  
Daan Nieboer ◽  
Sascha Verbruggen ◽  
...  
Keyword(s):  
Immune Response ◽  
Observational Study ◽  
Critically Ill ◽  
Prospective Observational Study ◽  
Secondary Infection ◽  
Critically Ill Children ◽  
Healthy Controls ◽  
Secondary Infections ◽  
Impaired Immune Response ◽  
Over Time

AbstractAn impaired immune response could play a role in the acquisition of secondary infections in critically ill children. Human leukocyte antigen-DR expression on monocytes (mHLA-DR) has been proposed as marker to detect immunosuppression, but its potential to predict secondary infections in critically ill children is unclear. We aimed to assess the association between mHLA-DR expression at several timepoints and the change of mHLA-DR expression over time with the acquisition of secondary infections in critically ill children. In this prospective observational study, children < 18 years with fever and/or suspected infection (community-acquired or hospital-acquired) were included at a paediatric intensive care unit in the Netherlands. mHLA-DR expression was determined by flow cytometry on day 1, day 2–3 and day 4–7. The association between delta-mHLA-DR expression (difference between last and first measurement) and secondary infection was assessed by multivariable regression analysis, adjusted for age and Paediatric Logistic Organ Dysfunction-2 score. We included 104 patients at the PICU (median age 1.2 years [IQR 0.3–4.2]), of whom 28 patients (27%) developed a secondary infection. Compared to 93 healthy controls, mHLA-DR expression of critically ill children was significantly lower at all timepoints. mHLA-DR expression did not differ at any of the time points between patients with and without secondary infection. In addition, delta-mHLA-DR expression was not associated with secondary infection (aOR 1.00 [95% CI 0.96–1.04]).Conclusions: Our results confirm that infectious critically ill children have significantly lower mHLA-DR expression than controls. mHLA-DR expression was not associated with the acquisition of secondary infections. What is Known:• An impaired immune response, estimated by mHLA-DR expression, could play an essential role in the acquisition of secondary infections in critically ill children.• In critically ill children, large studies on the association of mHLA-DR expression with secondary infections are scarce. What is New:• Our study confirms that critically ill children have lower mHLA-DR expression than healthy controls.• mHLA-DR expression and change in mHLA-DR was not associated with the acquisition of secondary infection.

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