scholarly journals Impact of biomarkers and genetic profiling on breast cancer prognostication: A comparative analysis of the 8th edition of breast cancer staging system

2019 ◽  
Vol 25 (5) ◽  
pp. 829-837 ◽  
Author(s):  
Esther C. Yoon ◽  
Christopher Schwartz ◽  
Edi Brogi ◽  
Katia Ventura ◽  
Hannah Wen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Comparative Analysis ◽  
Staging System ◽  
Cancer Staging ◽  
Genetic Profiling ◽  
Breast Cancer Staging ◽  
8Th Edition

Comparing the American Joint Committee on Cancer (AJCC) breast cancer staging eighth versus seventh edition and breast cancer biology in large databases.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12077-e12077
Author(s):  
Jessica S. Young ◽  
Kazuaki Takabe ◽  
Mariko Asaoka ◽  
Stephen B. Edge
Keyword(s):  
Breast Cancer ◽  
Cancer Biology ◽  
Staging System ◽  
Cancer Staging ◽  
Gene Set Enrichment Analysis ◽  
Breast Cancer Staging ◽  
7Th Edition ◽  
Stage 1 ◽  
8Th Edition ◽  
Better Than

e12077 Background: The AJCC 8th edition Breast Cancer Staging system includes biomarkers (estrogen receptor, progesterone receptor, Her2), grade and a genomic assay, to better reflect outcomes, compared to the 7th edition. We used databases with anatomic, biomarker and genomic information to determine if the 8th edition reflects biology better than the 7th edition. Methods: 696 breast cancer patients in The Cancer Genome Atlas (TCGA) and Text Information Extraction System (TIES) were staged both with 7th and 8th edition. Results: From the 7th to 8th editions, 66% of stage 2 patients migrated (64% to stage 1, 1.5% to stage 3). 36% of stage 3 patients migrated (22% to stage 1, 13% to stage 2). We analyzed the differences between stage 1 and 2 in both editions, and the overall survival hazard ratio calculated using Cox regression was greater in the 8th edition than the 7th (HR=1.50, HR=1.22 respectively). We performed Gene Set Enrichment Analysis (GSEA) and found that gene sets related to cell cycle and cell proliferation (E2F targets, G2M checkpoint) were significantly enriched in higher stage in 8th edition but not 7th. Mutant Allele Tumor Heterogeneity (MATH) and Homologous Recombination Defects (HRD) were elevated in higher stages in the 8th edition (p=0.022, p<0.001 respectively), but not the 7th. Immune cells (CD8 Tcell, NK cell) as well as CYT (Immune cytolytic activity score), and Tcell exhaustion markers (PD1, PDL1) were all found to be elevated in higher stage in 8th edition, but not 7th. Conclusions: The 8th edition AJCC Breast Cancer Staging system categorizes cancers by aggressive biology better than the 7th edition. We also found that higher stage tumors trigger an enhanced immune response, but are unable to overcome the aggressive cancer biology.

scholarly journals A Retrospective Analysis of Clinical Utility of AJCC 8th Edition Cancer Staging System for Breast Cancer

2017 ◽  
Vol 8 (3) ◽  
pp. 71-75 ◽  
Author(s):  
Hui Hu ◽  
Wei Wei ◽  
Xin Yi ◽  
Ling Xin ◽  
Yinhua Liu
Keyword(s):  
Breast Cancer ◽  
Retrospective Analysis ◽  
Clinical Utility ◽  
Staging System ◽  
Cancer Staging ◽  
8Th Edition

scholarly journals The Effect of the New Eighth Edition Breast Cancer Staging System on 100 Consecutive Patients

2019 ◽  
Vol 11 (6) ◽  
pp. 407-414 ◽  
Author(s):  
Ashley Biswal ◽  
Jacqueline Erler ◽  
Omar Qari ◽  
Arthur A. Topilow ◽  
Varsha Gupta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Staging System ◽  
Cancer Staging ◽  
Breast Cancer Staging ◽  
Eighth Edition

Abstract P5-06-09: Comparative analysis of proposed strategies for incorporating biologic factors into breast cancer staging

2020 ◽  
Author(s):  
Olga Kantor ◽  
Jiangong Niu ◽  
Hui Zhao ◽  
Sharon H Giordano ◽  
Kelly K Hunt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Comparative Analysis ◽  
Cancer Staging ◽  
Breast Cancer Staging ◽  
Biologic Factors

Incorporating Biologic Factors into the American Joint Committee on Cancer Breast Cancer Staging System

2018 ◽  
Vol 98 (4) ◽  
pp. 687-702 ◽  
Author(s):  
Anna Weiss ◽  
Tari A. King ◽  
Kelly K. Hunt ◽  
Elizabeth A. Mittendorf
Keyword(s):  
Breast Cancer ◽  
Staging System ◽  
Cancer Staging ◽  
Breast Cancer Staging ◽  
Cancer Breast ◽  
American Joint Committee ◽  
Biologic Factors

Should log odds of positive lymph node be incorporated into AJCC TNM breast cancer staging system?

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 11037-11037
Author(s):  
J. Wang ◽  
S. J. Anderson ◽  
J. P. Costantino ◽  
E. P. Mamounas ◽  
J. M. Hassett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Staging System ◽  
Cancer Staging ◽  
Positive Lymph Node ◽  
Breast Cancer Staging ◽  
Log Odds

scholarly journals Incorporating Tumor Characteristics to the American Joint Committee on Cancer Breast Cancer Staging System

2017 ◽  
Vol 22 (11) ◽  
pp. 1292-1300 ◽  
Author(s):  
Mariana Chavez‐MacGregor ◽  
Elizabeth A. Mittendorf ◽  
Christina A. Clarke ◽  
Daphne Y. Lichtensztajn ◽  
Kelly K. Hunt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Staging System ◽  
Cancer Staging ◽  
Tumor Characteristics ◽  
Breast Cancer Staging ◽  
Cancer Breast ◽  
American Joint Committee
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